Altiratinib (CHEM134512)
| Record Information | |||||||||
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| Version | 1.0 | ||||||||
| Creation Date | 2026-04-14 21:18:55 UTC | ||||||||
| Update Date | 2026-08-22 05:58:10 UTC | ||||||||
| Accession Number | CHEM134512 | ||||||||
| Identification | |||||||||
| Common Name | Altiratinib | ||||||||
| Class | Small Molecule | ||||||||
| Description | Altiratinib is an organic compound with the chemical formula C26H21F3N4O4. Altiratinib belongs to the ethers, a subclass of organooxygen compounds within the organic compounds. With an average molecular weight of 510.47 g/mol, Altiratinib is a heavy molecule. In terms of biological activity, this compound acts as an antagonist or inhibitor for five recorded protein targets. These include the Hepatocyte growth factor receptor (MET), the Vascular endothelial growth factor receptor 2 (KDR), the Angiopoietin-1 receptor (TEK), and the High affinity nerve growth factor receptor (NTRK1), along with one other protein. | ||||||||
| Contaminant Sources | Not Available | ||||||||
| Contaminant Type | Not Available | ||||||||
| Chemical Structure |  | ||||||||
| Synonyms | Not Available | ||||||||
| Chemical Formula | C26H21F3N4O4 | ||||||||
| Average Molecular Mass | 510.473 g/mol | ||||||||
| Monoisotopic Mass | 510.151 g/mol | ||||||||
| CAS Registry Number | 1345847-93-9 | ||||||||
| IUPAC Name | N1-{4-[(2-cyclopropaneamidopyridin-4-yl)oxy]-2,5-difluorophenyl}-N'1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | ||||||||
| Traditional Name | Not Available | ||||||||
| SMILES | FC1=CC=C(NC(=O)C2(CC2)C(=O)NC2=C(F)C=C(OC3=CC=NC(NC(=O)C4CC4)=C3)C(F)=C2)C=C1 | ||||||||
| InChI Identifier | InChI=1S/C26H21F3N4O4/c27-15-3-5-16(6-4-15)31-24(35)26(8-9-26)25(36)32-20-12-19(29)21(13-18(20)28)37-17-7-10-30-22(11-17)33-23(34)14-1-2-14/h3-7,10-14H,1-2,8-9H2,(H,31,35)(H,32,36)(H,30,33,34) | ||||||||
| InChI Key | GNNDEPIMDAZHRQ-UHFFFAOYSA-N | ||||||||
| Chemical Taxonomy | |||||||||
| Classification | Not classified | ||||||||
| Biological Properties | |||||||||
| Status | Detected and Not Quantified | ||||||||
| Origin | Not Available | ||||||||
| Cellular Locations | Not Available | ||||||||
| Biofluid Locations | Not Available | ||||||||
| Tissue Locations | Not Available | ||||||||
| Pathways | Not Available | ||||||||
| Applications | Not Available | ||||||||
| Biological Roles | Not Available | ||||||||
| Chemical Roles | Not Available | ||||||||
| Physical Properties | |||||||||
| State | Not Available | ||||||||
| Appearance | Not Available | ||||||||
| Experimental Properties |
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| Predicted Properties | Not Available | ||||||||
| Spectra | |||||||||
| Spectra |
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| Toxicity Profile | |||||||||
| Route of Exposure | Not Available | ||||||||
| Mechanism of Toxicity | Not Available | ||||||||
| Metabolism | Not Available | ||||||||
| Toxicity Values | Not Available | ||||||||
| Lethal Dose | Not Available | ||||||||
| Carcinogenicity (IARC Classification) | Not Available | ||||||||
| Uses/Sources | Not Available | ||||||||
| Minimum Risk Level | Not Available | ||||||||
| Health Effects | Not Available | ||||||||
| Symptoms | Not Available | ||||||||
| Treatment | Not Available | ||||||||
| Concentrations | |||||||||
| Not Available | |||||||||
| External Links | |||||||||
| Identifiers | Not Available | ||||||||
| References | |||||||||
| Synthesis Reference | Not Available | ||||||||
| MSDS | Not Available | ||||||||
| General References | Not Available | ||||||||
