138619 <common-name>Altiratinib</common-name> <description>Altiratinib is an organic compound with the chemical formula C26H21F3N4O4. Altiratinib belongs to the ethers, a subclass of organooxygen compounds within the organic compounds. With an average molecular weight of 510.47 g/mol, Altiratinib is a heavy molecule. In terms of biological activity, this compound acts as an antagonist or inhibitor for five recorded protein targets. These include the Hepatocyte growth factor receptor (MET), the Vascular endothelial growth factor receptor 2 (KDR), the Angiopoietin-1 receptor (TEK), and the High affinity nerve growth factor receptor (NTRK1), along with one other protein.</description> <cas>1345847-93-9</cas> <pubchem-id>54576299</pubchem-id> <chemical-formula>C26H21F3N4O4</chemical-formula> <weight>510.5</weight> <appearance nil="true"/> <melting-point nil="true"/> <boiling-point nil="true"/> <density nil="true"/> <solubility nil="true"/> <specific-gravity nil="true"/> <flash-point nil="true"/> <vapour-pressure nil="true"/> <route-of-exposure nil="true"/> <target nil="true"/> <mechanism-of-toxicity nil="true"/> <metabolism nil="true"/> <toxicity nil="true"/> <lethaldose nil="true"/> <carcinogenicity nil="true"/> <use-source nil="true"/> <min-risk-level nil="true"/> <health-effects nil="true"/> <symptoms nil="true"/> <treatment nil="true"/> <created-at type="dateTime">2026-04-14T21:18:55Z</created-at> <updated-at 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<moldb-mono-mass type="decimal">510.151489661</moldb-mono-mass> <origin nil="true"/> <state nil="true"/> <logp>4.5</logp> <hmdb-id nil="true"/> <chembl-id nil="true"/> <chemspider-id nil="true"/> <structure-image-file-name nil="true"/> <structure-image-content-type nil="true"/> <structure-image-file-size type="integer" nil="true"/> <structure-image-updated-at type="dateTime" nil="true"/> <biodb-id nil="true"/> <synthesis-reference nil="true"/> <structure-image-caption nil="true"/> <chemdb-id>CHEM134512</chemdb-id> <dsstox-id nil="true"/> <toxcast-id nil="true"/> <stoff-ident-origin nil="true"/> <stoff-ident-id nil="true"/> <susdat-id nil="true"/> <iupac>N1-{4-[(2-cyclopropaneamidopyridin-4-yl)oxy]-2,5-difluorophenyl}-N'1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide</iupac> <moldb-polar-surface-area nil="true"/> <moldb-refractivity nil="true"/> <moldb-polarizability nil="true"/> <moldb-rotatable-bond-count nil="true"/> <moldb-acceptor-count nil="true"/> <moldb-donor-count nil="true"/> <moldb-pka-strongest-acidic nil="true"/> <moldb-pka-strongest-basic nil="true"/> <moldb-physiological-charge nil="true"/> <moldb-number-of-rings nil="true"/> <moldb-alogps-logp nil="true"/> <moldb-alogps-logs nil="true"/> <moldb-alogps-solubility nil="true"/> <kingdom>Organic compounds</kingdom> <superklass>Organic oxygen compounds</superklass> <klass>Organooxygen compounds</klass> <subklass>Ethers</subklass> <paper-count type="integer">144</paper-count> <sync-id>CED0016990</sync-id> <structure-inchikey>GNNDEPIMDAZHRQ-UHFFFAOYSA-N</structure-inchikey> 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