Tipifarnib (CHEM102354)
| Record Information | |||||||||
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| Version | 1.0 | ||||||||
| Creation Date | 2026-04-05 13:10:20 UTC | ||||||||
| Update Date | 2026-08-22 07:12:21 UTC | ||||||||
| Accession Number | CHEM102354 | ||||||||
| Identification | |||||||||
| Common Name | Tipifarnib | ||||||||
| Class | Small Molecule | ||||||||
| Description | Tipifarnib is an organic compound with the chemical formula C27H22Cl2N4O and an average molecular weight of 489.40 g/mol. Tipifarnib belongs to the linear diarylheptanoids, a subclass of diarylheptanoids within the organic compounds. In terms of its biological activity, the compound acts upon three recorded protein targets. It functions as an inhibitor or modulator of protein farnesyltransferase subunit beta (FNTB), protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA), and farnesyl pyrophosphate synthase (FDPS). | ||||||||
| Contaminant Sources | Not Available | ||||||||
| Contaminant Type | Not Available | ||||||||
| Chemical Structure |  | ||||||||
| Synonyms | Not Available | ||||||||
| Chemical Formula | C27H22Cl2N4O | ||||||||
| Average Molecular Mass | 489.400 g/mol | ||||||||
| Monoisotopic Mass | 488.117 g/mol | ||||||||
| CAS Registry Number | 192185-72-1 | ||||||||
| IUPAC Name | 6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-1,2-dihydroquinolin-2-one | ||||||||
| Traditional Name | Not Available | ||||||||
| SMILES | CN1C=NC=C1[C@@](N)(C1=CC=C(Cl)C=C1)C1=CC2=C(C=C1)N(C)C(=O)C=C2C1=CC=CC(Cl)=C1 | ||||||||
| InChI Identifier | InChI=1S/C27H22Cl2N4O/c1-32-16-31-15-25(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(34)33(24)2)17-4-3-5-21(29)12-17/h3-16H,30H2,1-2H3/t27-/m1/s1 | ||||||||
| InChI Key | PLHJCIYEEKOWNM-HHHXNRCGSA-N | ||||||||
| Chemical Taxonomy | |||||||||
| Classification | Not classified | ||||||||
| Biological Properties | |||||||||
| Status | Detected and Not Quantified | ||||||||
| Origin | Not Available | ||||||||
| Cellular Locations | Not Available | ||||||||
| Biofluid Locations | Not Available | ||||||||
| Tissue Locations | Not Available | ||||||||
| Pathways | Not Available | ||||||||
| Applications | Not Available | ||||||||
| Biological Roles | Not Available | ||||||||
| Chemical Roles | Not Available | ||||||||
| Physical Properties | |||||||||
| State | Not Available | ||||||||
| Appearance | Not Available | ||||||||
| Experimental Properties |
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| Predicted Properties | Not Available | ||||||||
| Spectra | |||||||||
| Spectra |
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| Toxicity Profile | |||||||||
| Route of Exposure | Not Available | ||||||||
| Mechanism of Toxicity | Not Available | ||||||||
| Metabolism | Not Available | ||||||||
| Toxicity Values | Not Available | ||||||||
| Lethal Dose | Not Available | ||||||||
| Carcinogenicity (IARC Classification) | Not Available | ||||||||
| Uses/Sources | Not Available | ||||||||
| Minimum Risk Level | Not Available | ||||||||
| Health Effects | Not Available | ||||||||
| Symptoms | Not Available | ||||||||
| Treatment | Not Available | ||||||||
| Concentrations | |||||||||
| Not Available | |||||||||
| External Links | |||||||||
| Identifiers | Not Available | ||||||||
| References | |||||||||
| Synthesis Reference | Not Available | ||||||||
| MSDS | Not Available | ||||||||
| General References | Not Available | ||||||||
