106461 <common-name>Tipifarnib</common-name> <description>Tipifarnib is an organic compound with the chemical formula C27H22Cl2N4O and an average molecular weight of 489.40 g/mol. Tipifarnib belongs to the linear diarylheptanoids, a subclass of diarylheptanoids within the organic compounds. In terms of its biological activity, the compound acts upon three recorded protein targets. It functions as an inhibitor or modulator of protein farnesyltransferase subunit beta (FNTB), protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA), and farnesyl pyrophosphate synthase (FDPS).</description> <cas>192185-72-1</cas> <pubchem-id>159324</pubchem-id> <chemical-formula>C27H22Cl2N4O</chemical-formula> <weight>489.4</weight> <appearance nil="true"/> <melting-point nil="true"/> <boiling-point nil="true"/> <density nil="true"/> <solubility nil="true"/> <specific-gravity nil="true"/> <flash-point nil="true"/> <vapour-pressure nil="true"/> <route-of-exposure nil="true"/> <target nil="true"/> <mechanism-of-toxicity nil="true"/> <metabolism nil="true"/> <toxicity nil="true"/> <lethaldose nil="true"/> <carcinogenicity nil="true"/> <use-source nil="true"/> <min-risk-level nil="true"/> <health-effects nil="true"/> <symptoms nil="true"/> <treatment nil="true"/> <created-at type="dateTime">2026-04-05T13:10:20Z</created-at> <updated-at type="dateTime">2026-08-22T07:12:21Z</updated-at> <interacting-proteins nil="true"/> <wikipedia nil="true"/> <uniprot-id nil="true"/> <kegg-compound-id nil="true"/> <omim-id nil="true"/> <chebi-id nil="true"/> <biocyc-id nil="true"/> <ctd-id nil="true"/> <stitch-id nil="true"/> <drugbank-id>DB04960</drugbank-id> <pdb-id nil="true"/> <actor-id nil="true"/> <organism nil="true"/> <export type="boolean">true</export> <metabolizing-proteins nil="true"/> <transporting-proteins nil="true"/> <moldb-smiles>CN1C=NC=C1[C@@](N)(C1=CC=C(Cl)C=C1)C1=CC2=C(C=C1)N(C)C(=O)C=C2C1=CC=CC(Cl)=C1</moldb-smiles> <moldb-formula>C27H22Cl2N4O</moldb-formula> <moldb-inchi>InChI=1S/C27H22Cl2N4O/c1-32-16-31-15-25(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(34)33(24)2)17-4-3-5-21(29)12-17/h3-16H,30H2,1-2H3/t27-/m1/s1</moldb-inchi> <moldb-inchikey>PLHJCIYEEKOWNM-HHHXNRCGSA-N</moldb-inchikey> <moldb-average-mass type="decimal">489.4</moldb-average-mass> <moldb-mono-mass type="decimal">488.1170667</moldb-mono-mass> <origin nil="true"/> <state nil="true"/> <logp>4.69</logp> <hmdb-id nil="true"/> <chembl-id nil="true"/> <chemspider-id nil="true"/> <structure-image-file-name nil="true"/> <structure-image-content-type nil="true"/> <structure-image-file-size type="integer" nil="true"/> <structure-image-updated-at type="dateTime" nil="true"/> <biodb-id nil="true"/> <synthesis-reference nil="true"/> <structure-image-caption nil="true"/> <chemdb-id>CHEM102354</chemdb-id> <dsstox-id>DTXSID5041140</dsstox-id> <toxcast-id nil="true"/> <stoff-ident-origin nil="true"/> <stoff-ident-id nil="true"/> <susdat-id>NS00071731</susdat-id> <iupac>6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-1,2-dihydroquinolin-2-one</iupac> <moldb-polar-surface-area nil="true"/> <moldb-refractivity nil="true"/> <moldb-polarizability nil="true"/> <moldb-rotatable-bond-count nil="true"/> <moldb-acceptor-count nil="true"/> <moldb-donor-count nil="true"/> <moldb-pka-strongest-acidic nil="true"/> <moldb-pka-strongest-basic nil="true"/> <moldb-physiological-charge nil="true"/> <moldb-number-of-rings nil="true"/> <moldb-alogps-logp nil="true"/> <moldb-alogps-logs nil="true"/> <moldb-alogps-solubility nil="true"/> <kingdom>Organic compounds</kingdom> <superklass>Phenylpropanoids and polyketides</superklass> <klass>Diarylheptanoids</klass> <subklass>Linear diarylheptanoids</subklass> <paper-count type="integer">2719</paper-count> <sync-id>CED0005750</sync-id> <structure-inchikey>PLHJCIYEEKOWNM-HHHXNRCGSA-N</structure-inchikey> <structure-fingerprint>402000000000000002000010000000400000000000080000020080000000000000020020000008000002000000000000000000000000000000000000000000000480000008000000000000020000010000000100000408000000000000000000080000010000000100000000000000900000000000000000000000021000040020000800000000000044000901000000000000000000000000000000000000000000010040000080000004040000010000000080000000000000100020000000100001000000000000000400010000000000200000200000000000000000000000000000041000000000008000000000000000000000004000000</structure-fingerprint> <structure-pattern-fingerprint>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</structure-pattern-fingerprint> <structure-pickle>ï¾­Þ����������������"���&���€���`������@(������@h�������@(������@h�������@(������ $�������`������@(������@h�������@h�������@(������� �����@h�������@h�������@(������@h�������@(������@(������@h�������@h�������@(�������`������@(�������(������@h�������@(������@(������@h�������@h�������@h�������@(������� �����@h������������h���h���h���h����������� h� h� �h����� h� �h������h���h���h���h���h���h������h���(���h���h��� ��h���h���h���h�� ��!h���h���h���h�!�h���h�B����������� � ���������������������!�����������</structure-pickle> <structure-indexed-at type="dateTime">2026-09-19T04:42:04Z</structure-indexed-at> </compound>