Difamilast (CHEM132704)
| Record Information | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Version | 1.0 | ||||||||
| Creation Date | 2026-04-14 20:02:34 UTC | ||||||||
| Update Date | 2026-08-22 00:16:03 UTC | ||||||||
| Accession Number | CHEM132704 | ||||||||
| Identification | |||||||||
| Common Name | Difamilast | ||||||||
| Class | Small Molecule | ||||||||
| Description | Difamilast is an organic compound with the chemical formula C23H24F2N2O5 and an average molecular weight of 446.45 g/mol. Difamilast belongs to the oxazoles, a subclass of azoles within the organic compounds. Within the broader hierarchy of chemical classification, it is categorized under the superclass of organoheterocyclic compounds. This compound acts as an inhibitor for four specific protein targets: 3',5'-cyclic-AMP phosphodiesterase 4A (PDE4A), 3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B), 3',5'-cyclic-AMP phosphodiesterase 4C (PDE4C), and 3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D). Regarding its environmental presence, difamilast has been found in or released from two recorded sources, specifically electrical and electronic equipment including cores yokes or armatures and colour television systems. | ||||||||
| Contaminant Sources | Not Available | ||||||||
| Contaminant Type | Not Available | ||||||||
| Chemical Structure |  | ||||||||
| Synonyms | Not Available | ||||||||
| Chemical Formula | C23H24F2N2O5 | ||||||||
| Average Molecular Mass | 446.451 g/mol | ||||||||
| Monoisotopic Mass | 446.165 g/mol | ||||||||
| CAS Registry Number | 937782-05-3 | ||||||||
| IUPAC Name | N-({2-[4-(difluoromethoxy)-3-(propan-2-yloxy)phenyl]-1,3-oxazol-4-yl}methyl)-2-ethoxybenzamide | ||||||||
| Traditional Name | Not Available | ||||||||
| SMILES | CCOC1=CC=CC=C1C(=O)NCC1=COC(=N1)C1=CC=C(OC(F)F)C(OC(C)C)=C1 | ||||||||
| InChI Identifier | InChI=1S/C23H24F2N2O5/c1-4-29-18-8-6-5-7-17(18)21(28)26-12-16-13-30-22(27-16)15-9-10-19(32-23(24)25)20(11-15)31-14(2)3/h5-11,13-14,23H,4,12H2,1-3H3,(H,26,28) | ||||||||
| InChI Key | VFBILHPIHUPBPZ-UHFFFAOYSA-N | ||||||||
| Chemical Taxonomy | |||||||||
| Classification | Not classified | ||||||||
| Biological Properties | |||||||||
| Status | Detected and Not Quantified | ||||||||
| Origin | Not Available | ||||||||
| Cellular Locations | Not Available | ||||||||
| Biofluid Locations | Not Available | ||||||||
| Tissue Locations | Not Available | ||||||||
| Pathways | Not Available | ||||||||
| Applications | Not Available | ||||||||
| Biological Roles | Not Available | ||||||||
| Chemical Roles | Not Available | ||||||||
| Physical Properties | |||||||||
| State | Not Available | ||||||||
| Appearance | Not Available | ||||||||
| Experimental Properties |
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| Predicted Properties | Not Available | ||||||||
| Spectra | |||||||||
| Spectra |
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| Toxicity Profile | |||||||||
| Route of Exposure | Not Available | ||||||||
| Mechanism of Toxicity | Not Available | ||||||||
| Metabolism | Not Available | ||||||||
| Toxicity Values | Not Available | ||||||||
| Lethal Dose | Not Available | ||||||||
| Carcinogenicity (IARC Classification) | Not Available | ||||||||
| Uses/Sources | Not Available | ||||||||
| Minimum Risk Level | Not Available | ||||||||
| Health Effects | Not Available | ||||||||
| Symptoms | Not Available | ||||||||
| Treatment | Not Available | ||||||||
| Concentrations | |||||||||
| Not Available | |||||||||
| External Links | |||||||||
| Identifiers | Not Available | ||||||||
| References | |||||||||
| Synthesis Reference | Not Available | ||||||||
| MSDS | Not Available | ||||||||
| General References | Not Available | ||||||||
