GSK-1004723 (CHEM131719)

IdentificationTaxonomyBiological PropertiesPhysical PropertiesToxicity ProfileSpectraConcentrationsLinksReferencesTargets (27)XML
Record Information
Version1.0
Creation Date2026-04-14 19:05:03 UTC
Update Date2026-08-22 12:15:20 UTC
Accession NumberCHEM131719
Identification
Common NameGSK-1004723
ClassSmall Molecule
DescriptionGSK-1004723 is an organic compound with the chemical formula C39H49ClN4O2. GSK-1004723 belongs to the benzodiazines, a subclass of diazanaphthalenes within the organic compounds. With an average molecular weight of 641.30 g/mol, GSK-1004723 is a heavy molecule. This organoheterocyclic compound acts as an antagonist for two protein targets: the Histamine H1 receptor (HRH1) and the Histamine H3 receptor (HRH3).
Contaminant SourcesNot Available
Contaminant TypeNot Available
Chemical Structure
Thumb
MOLSDFPDBSMILESInChI
SynonymsNot Available
Chemical FormulaC39H49ClN4O2
Average Molecular Mass641.300 g/mol
Monoisotopic Mass640.354 g/mol
CAS Registry Number955359-72-5
IUPAC Name2-{[(2R)-1-(4-{4-[3-(azepan-1-yl)propoxy]phenyl}butyl)pyrrolidin-2-yl]methyl}-4-[(4-chlorophenyl)methyl]-1,2-dihydrophthalazin-1-one
Traditional NameNot Available
SMILESClC1=CC=C(CC2=NN(C[C@H]3CCCN3CCCCC3=CC=C(OCCCN4CCCCCC4)C=C3)C(=O)C3=CC=CC=C23)C=C1
InChI IdentifierInChI=1S/C39H49ClN4O2/c40-33-19-15-32(16-20-33)29-38-36-13-3-4-14-37(36)39(45)44(41-38)30-34-12-9-27-43(34)26-8-5-11-31-17-21-35(22-18-31)46-28-10-25-42-23-6-1-2-7-24-42/h3-4,13-22,34H,1-2,5-12,23-30H2/t34-/m1/s1
InChI KeyYANGEESWIGIKOP-UUWRZZSWSA-N
Chemical Taxonomy
ClassificationNot classified
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
Pathways
NameSMPDB LinkKEGG Link
GSK-1004723 H1 Antihistamine Smooth Muscle Relaxation Action PathwaySMP0174955 Not Available
GSK-1004723 H1-Antihistamine Blood Vessel Constriction Action PathwaySMP0175047 Not Available
GSK-1004723 H1-Antihistamine Immune Response Action PathwaySMP0175139 Not Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted PropertiesNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyView
Toxicity Profile
Route of ExposureNot Available
Mechanism of ToxicityNot Available
MetabolismNot Available
Toxicity ValuesNot Available
Lethal DoseNot Available
Carcinogenicity (IARC Classification)Not Available
Uses/SourcesNot Available
Minimum Risk LevelNot Available
Health EffectsNot Available
SymptomsNot Available
TreatmentNot Available
Concentrations
Not Available
IdentifiersNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General ReferencesNot Available