Glasdegib (CHEM103247)
| Record Information | ||||||||||
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| Version | 1.0 | |||||||||
| Creation Date | 2026-04-05 13:48:55 UTC | |||||||||
| Update Date | 2026-08-21 18:49:28 UTC | |||||||||
| Accession Number | CHEM103247 | |||||||||
| Identification | ||||||||||
| Common Name | Glasdegib | |||||||||
| Class | Small Molecule | |||||||||
| Description | Glasdegib is an organic compound with the formula C21H22N6O and an average molecular weight of 374.45 g/mol. Glasdegib belongs to the n-phenylureas, a subclass of benzene and substituted derivatives within the organic compounds. This compound is recorded as being released from healthcare, pharmaceuticals, and veterinary products, specifically as an antineoplastic agent, with an oral exposure route. It acts on two recorded protein targets, serving as an inhibitor of Protein smoothened (SMO) and Serine/threonine-protein kinase mTOR (MTOR). | |||||||||
| Contaminant Sources | Not Available | |||||||||
| Contaminant Type | Not Available | |||||||||
| Chemical Structure |  | |||||||||
| Synonyms | Not Available | |||||||||
| Chemical Formula | C21H22N6O | |||||||||
| Average Molecular Mass | 374.448 g/mol | |||||||||
| Monoisotopic Mass | 374.186 g/mol | |||||||||
| CAS Registry Number | 1095173-27-5 | |||||||||
| IUPAC Name | 1-[(2R,4R)-2-(1H-1,3-benzodiazol-2-yl)-1-methylpiperidin-4-yl]-3-(4-cyanophenyl)urea | |||||||||
| Traditional Name | Not Available | |||||||||
| SMILES | CN1CC[C@H](C[C@@H]1C1=NC2=CC=CC=C2N1)NC(=O)NC1=CC=C(C=C1)C#N | |||||||||
| InChI Identifier | InChI=1S/C21H22N6O/c1-27-11-10-16(24-21(28)23-15-8-6-14(13-22)7-9-15)12-19(27)20-25-17-4-2-3-5-18(17)26-20/h2-9,16,19H,10-12H2,1H3,(H,25,26)(H2,23,24,28)/t16-,19-/m1/s1 | |||||||||
| InChI Key | SFNSLLSYNZWZQG-VQIMIIECSA-N | |||||||||
| Chemical Taxonomy | ||||||||||
| Classification | Not classified | |||||||||
| Biological Properties | ||||||||||
| Status | Detected and Not Quantified | |||||||||
| Origin | Not Available | |||||||||
| Cellular Locations | Not Available | |||||||||
| Biofluid Locations | Not Available | |||||||||
| Tissue Locations | Not Available | |||||||||
| Pathways |
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| Applications | Not Available | |||||||||
| Biological Roles | Not Available | |||||||||
| Chemical Roles | Not Available | |||||||||
| Physical Properties | ||||||||||
| State | Not Available | |||||||||
| Appearance | Not Available | |||||||||
| Experimental Properties |
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| Predicted Properties | Not Available | |||||||||
| Spectra | ||||||||||
| Spectra |
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| Toxicity Profile | ||||||||||
| Route of Exposure | Not Available | |||||||||
| Mechanism of Toxicity | Not Available | |||||||||
| Metabolism | Not Available | |||||||||
| Toxicity Values | Not Available | |||||||||
| Lethal Dose | Not Available | |||||||||
| Carcinogenicity (IARC Classification) | Not Available | |||||||||
| Uses/Sources | Not Available | |||||||||
| Minimum Risk Level | Not Available | |||||||||
| Health Effects | Not Available | |||||||||
| Symptoms | Not Available | |||||||||
| Treatment | Not Available | |||||||||
| Concentrations | ||||||||||
| Not Available | ||||||||||
| External Links | ||||||||||
| Identifiers | Not Available | |||||||||
| References | ||||||||||
| Synthesis Reference | Not Available | |||||||||
| MSDS | Not Available | |||||||||
| General References | Not Available | |||||||||
