Record Information |
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Version | 1.0 |
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Creation Date | 2016-06-03 11:14:01 UTC |
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Update Date | 2016-11-09 01:22:59 UTC |
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Accession Number | CHEM043749 |
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Identification |
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Common Name | lofepramide |
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Class | Small Molecule |
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Description | |
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Contaminant Sources | |
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Contaminant Type | Not Available |
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Chemical Structure | |
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Synonyms | Value | Source |
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1-(4-Chlorophenyl)-2-{[3-(10,11-dihydro-5H-dibenzo[b,F]azepin-5-yl)propyl]methylamino}ethanone | ChEBI | 4'-Chlor-2-((3-(10,11-dihydro-5H-dibenz(b,F)azepin-5-yl)propyl)methylamino)acetophenon | ChEBI | 4'-Chloro-2-((3-(10,11-dihydro-5H-dibenz(b,F)azepin5-yl)propyl)methylamino)acetophenone | ChEBI | Lopramine | ChEBI | Feprapax | MeSH | Ashbourne brand OF lofepramine hydrochloride | MeSH | leo 640 | MeSH | Lomont | MeSH | Gamanil | MeSH | Hydrochloride, lofepramine | MeSH | Merck brand OF lofepramine hydrochloride | MeSH | Rosemont brand OF lofepramine hydrochloride | MeSH | Deftan | MeSH | Lofepramine hydrochloride | MeSH | Gamonil | MeSH |
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Chemical Formula | C26H27ClN2O |
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Average Molecular Mass | 418.970 g/mol |
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Monoisotopic Mass | 418.181 g/mol |
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CAS Registry Number | 23047-25-8 |
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IUPAC Name | 2-[(3-{2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaen-2-yl}propyl)(methyl)amino]-1-(4-chlorophenyl)ethan-1-one |
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Traditional Name | 2-[(3-{2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaen-2-yl}propyl)(methyl)amino]-1-(4-chlorophenyl)ethanone |
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SMILES | CN(CCCN1C2=CC=CC=C2CCC2=CC=CC=C12)CC(=O)C1=CC=C(Cl)C=C1 |
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InChI Identifier | InChI=1S/C26H27ClN2O/c1-28(19-26(30)22-13-15-23(27)16-14-22)17-6-18-29-24-9-4-2-7-20(24)11-12-21-8-3-5-10-25(21)29/h2-5,7-10,13-16H,6,11-12,17-19H2,1H3 |
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InChI Key | SAPNXPWPAUFAJU-UHFFFAOYSA-N |
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Chemical Taxonomy |
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Description | belongs to the class of organic compounds known as dibenzazepines. Dibenzazepines are compounds with two benzene rings connected by an azepine ring. Azepine is an unsaturated seven-member heterocycle with one nitrogen atom replacing a carbon atom. |
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Kingdom | Organic compounds |
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Super Class | Organoheterocyclic compounds |
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Class | Benzazepines |
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Sub Class | Dibenzazepines |
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Direct Parent | Dibenzazepines |
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Alternative Parents | |
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Substituents | - Dibenzazepine
- Alkyl-phenylketone
- Alkyldiarylamine
- Phenylketone
- Benzoyl
- Tertiary aliphatic/aromatic amine
- Aryl ketone
- Aryl alkyl ketone
- Azepine
- Chlorobenzene
- Halobenzene
- Aryl halide
- Aryl chloride
- Benzenoid
- Monocyclic benzene moiety
- Alpha-aminoketone
- Tertiary aliphatic amine
- Tertiary amine
- Ketone
- Azacycle
- Hydrocarbon derivative
- Organooxygen compound
- Organic nitrogen compound
- Amine
- Organopnictogen compound
- Organic oxide
- Organic oxygen compound
- Organohalogen compound
- Organochloride
- Organonitrogen compound
- Aromatic heteropolycyclic compound
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Molecular Framework | Aromatic heteropolycyclic compounds |
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External Descriptors | |
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Biological Properties |
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Status | Detected and Not Quantified |
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Origin | Not Available |
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Cellular Locations | Not Available |
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Biofluid Locations | Not Available |
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Tissue Locations | Not Available |
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Pathways | Not Available |
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Applications | Not Available |
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Biological Roles | Not Available |
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Chemical Roles | Not Available |
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Physical Properties |
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State | Not Available |
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Appearance | Not Available |
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Experimental Properties | Property | Value |
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Melting Point | Not Available | Boiling Point | Not Available | Solubility | Not Available |
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Predicted Properties | |
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Spectra |
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Spectra | Spectrum Type | Description | Splash Key | View |
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Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | splash10-052r-3930000000-7f3233101e9bc3c16ac2 | Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | Not Available | Spectrum | LC-MS/MS | LC-MS/MS Spectrum - 35V, Positive | splash10-00di-0190000000-939eaff7e4c449d10e95 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-014i-0030900000-f2c1472e308c1b5aef4b | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-00tr-1390200000-e0f7a25f6e2c3cf8cf45 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0017-7950000000-f7cfdbd1d08c3c9e7b07 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-014i-0100900000-0c66d04816128a1bd142 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-015c-0911400000-f3a351150cd2f078f73a | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-00kf-1900000000-239b62d416a315bf9bef | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-014i-0010900000-417d70665e251f5a9161 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-00yr-3790300000-35b025799d6e47a8cf30 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-000i-2950000000-3b5dd2fb9a45903de9ec | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-014i-0000900000-b75a2d50ee5a83773f68 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-00l6-1970700000-92d67c757a3b7ac10b0e | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-001i-9310100000-31a976888a2df4b86577 | Spectrum |
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Toxicity Profile |
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Route of Exposure | Not Available |
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Mechanism of Toxicity | Not Available |
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Metabolism | Not Available |
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Toxicity Values | Not Available |
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Lethal Dose | Not Available |
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Carcinogenicity (IARC Classification) | Not Available |
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Uses/Sources | Not Available |
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Minimum Risk Level | Not Available |
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Health Effects | Not Available |
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Symptoms | Not Available |
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Treatment | Not Available |
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Concentrations |
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| Not Available |
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External Links |
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DrugBank ID | DB13411 |
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HMDB ID | Not Available |
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FooDB ID | Not Available |
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Phenol Explorer ID | Not Available |
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KNApSAcK ID | Not Available |
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BiGG ID | Not Available |
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BioCyc ID | Not Available |
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METLIN ID | Not Available |
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PDB ID | Not Available |
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Wikipedia Link | Lofepramine |
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Chemspider ID | Not Available |
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ChEBI ID | 47782 |
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PubChem Compound ID | 3947 |
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Kegg Compound ID | Not Available |
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YMDB ID | Not Available |
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ECMDB ID | Not Available |
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References |
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Synthesis Reference | Not Available |
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MSDS | Not Available |
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General References | Not Available |
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