Record Information |
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Version | 1.0 |
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Creation Date | 2016-06-03 10:01:40 UTC |
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Update Date | 2016-11-09 01:22:43 UTC |
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Accession Number | CHEM042618 |
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Identification |
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Common Name | bis(POC)PMPA, bis(POC)PMPA, bis(POC)PMPA, bis(POC)PMPA, bis(POC)PMPA |
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Class | Small Molecule |
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Description | An organic phosphonate that is the disoproxil ester of tenofovir. A prodrug for tenofovir, an HIV-1 reverse transcriptase inhibitor, tenofovir disoproxil is used as the fumaric acid salt in combination therapy for the treatment of HIV infection. |
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Contaminant Sources | |
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Contaminant Type | Not Available |
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Chemical Structure | |
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Synonyms | Value | Source |
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9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine | ChEBI | Bis(POC)pmpa | ChEBI | PMPA prodrug | ChEBI | Tenofovir bis(isopropyloxycarbonyloxymethyl) ester | ChEBI | Fumarate, tenofovir disoproxil | MeSH | 9-(2-Phosphonylmethoxypropyl)adenine, (+-)-isomer | MeSH | Tenofovir | MeSH | 9-(2-Phosphonylmethoxypropyl)adenine, (S)-isomer | MeSH | 9-(2-Phosphonylmethoxypropyl)adenine | MeSH | Viread | MeSH | 9-PMPA (tenofovir) | MeSH | 9-(2-Phosphonylmethoxypropyl)adenine, (R)-isomer - T357098 | MeSH | Disoproxil fumarate, tenofovir | MeSH | (R)-9-(2-Phosphonylmethoxypropyl)adenine | MeSH | 9-(2-Phosphonomethoxypropyl)adenine | MeSH | Disoproxil, tenofovir | MeSH | Tenofovir disoproxil fumarate | MeSH | Bis({[(propan-2-yloxy)carbonyl]oxy}methyl) {[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methanephosphonic acid | Generator |
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Chemical Formula | C19H30N5O10P |
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Average Molecular Mass | 519.448 g/mol |
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Monoisotopic Mass | 519.173 g/mol |
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CAS Registry Number | 201341-05-1 |
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IUPAC Name | bis({[(propan-2-yloxy)carbonyl]oxy}methyl) {[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methanephosphonate |
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Traditional Name | pmpa prodrug |
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SMILES | [H][C@@](C)(CN1C=NC2=C(N)N=CN=C12)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C |
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InChI Identifier | InChI=1S/C19H30N5O10P/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22)/t14-/m1/s1 |
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InChI Key | JFVZFKDSXNQEJW-CQSZACIVSA-N |
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Chemical Taxonomy |
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Description | belongs to the class of organic compounds known as 6-aminopurines. These are purines that carry an amino group at position 6. Purine is a bicyclic aromatic compound made up of a pyrimidine ring fused to an imidazole ring. |
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Kingdom | Organic compounds |
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Super Class | Organoheterocyclic compounds |
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Class | Imidazopyrimidines |
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Sub Class | Purines and purine derivatives |
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Direct Parent | 6-aminopurines |
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Alternative Parents | |
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Substituents | - 6-aminopurine
- Aminopyrimidine
- Dialkyl alkylphosphonate
- Phosphonic acid diester
- Carbonic acid diester
- Imidolactam
- Pyrimidine
- N-substituted imidazole
- Phosphonic acid ester
- Azole
- Imidazole
- Heteroaromatic compound
- Organophosphonic acid derivative
- Carbonic acid derivative
- Azacycle
- Organic nitrogen compound
- Organonitrogen compound
- Organooxygen compound
- Organophosphorus compound
- Primary amine
- Hydrocarbon derivative
- Carbonyl group
- Organic oxide
- Organopnictogen compound
- Organic oxygen compound
- Amine
- Aromatic heteropolycyclic compound
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Molecular Framework | Aromatic heteropolycyclic compounds |
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External Descriptors | |
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Biological Properties |
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Status | Detected and Not Quantified |
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Origin | Not Available |
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Cellular Locations | Not Available |
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Biofluid Locations | Not Available |
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Tissue Locations | Not Available |
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Pathways | Not Available |
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Applications | Not Available |
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Biological Roles | Not Available |
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Chemical Roles | Not Available |
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Physical Properties |
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State | Not Available |
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Appearance | Not Available |
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Experimental Properties | Property | Value |
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Melting Point | Not Available | Boiling Point | Not Available | Solubility | Not Available |
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Predicted Properties | |
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Spectra |
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Spectra | Spectrum Type | Description | Splash Key | View |
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Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-0zi9-1923410000-5f1cd970edf5f04f33a6 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-01ti-6935400000-aa42e62ec1896201d6a8 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-000i-7913000000-545bd583eab18a2ac9bb | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-03di-1535920000-7d0f7a9518484f92d296 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-001i-1911000000-91af4bd4b9fc5980fe6d | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-001i-1900000000-436151173cf8dcae5801 | Spectrum |
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Toxicity Profile |
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Route of Exposure | Not Available |
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Mechanism of Toxicity | Not Available |
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Metabolism | Not Available |
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Toxicity Values | Not Available |
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Lethal Dose | Not Available |
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Carcinogenicity (IARC Classification) | Not Available |
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Uses/Sources | Not Available |
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Minimum Risk Level | Not Available |
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Health Effects | Not Available |
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Symptoms | Not Available |
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Treatment | Not Available |
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Concentrations |
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| Not Available |
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External Links |
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DrugBank ID | DB00300 |
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HMDB ID | Not Available |
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FooDB ID | Not Available |
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Phenol Explorer ID | Not Available |
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KNApSAcK ID | Not Available |
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BiGG ID | Not Available |
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BioCyc ID | Not Available |
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METLIN ID | Not Available |
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PDB ID | Not Available |
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Wikipedia Link | Tenofovir disoproxil |
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Chemspider ID | Not Available |
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ChEBI ID | 63717 |
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PubChem Compound ID | 5481350 |
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Kegg Compound ID | Not Available |
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YMDB ID | Not Available |
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ECMDB ID | Not Available |
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References |
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Synthesis Reference | Not Available |
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MSDS | Not Available |
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General References | Not Available |
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