Record Information |
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Version | 1.0 |
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Creation Date | 2016-05-26 05:59:22 UTC |
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Update Date | 2016-11-09 01:21:21 UTC |
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Accession Number | CHEM035686 |
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Identification |
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Common Name | 7b-Hydroxydehydroepiandrosterone |
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Class | Small Molecule |
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Description | |
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Contaminant Sources | |
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Contaminant Type | Not Available |
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Chemical Structure | |
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Synonyms | Value | Source |
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(3b,7b)-3,7-Dihydroxy-androst-5-en-17-one | HMDB | 3b,7b-Dihydroxy-5-androsten-17-one | HMDB | 3b,7b-Dihydroxy-5-androstene-17-one | HMDB | 3b,7b-Dihydroxy-androst-5-en-17-one | HMDB | 3b,7b-Dihydroxy-ost-5-en-17-one | HMDB | 7-b-OH-DHEA | HMDB | 7-beta-OH-DHEA | HMDB | 7b-Hydroxy dehydroepiandrosterone | HMDB | 7b-Hydroxy-dhea | HMDB | Androst-5-ene-3b,7b-diol-17-one | HMDB | 7-Hydroxydehydroepiandrosterone, (3beta)-isomer | MeSH, HMDB | 7beta-OH-DHEA | MeSH, HMDB | 7beta-Hydroxydehydroepiandrosterone | MeSH, HMDB | 7 alpha-Hydroxydehydroepiandrosterone | MeSH, HMDB | 7-Hydroxydehydroepiandrosterone, (3beta,7beta)-isomer | MeSH, HMDB | 7-Hydroxydehydroepiandrosterone | MeSH, HMDB |
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Chemical Formula | C19H28O3 |
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Average Molecular Mass | 304.424 g/mol |
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Monoisotopic Mass | 304.204 g/mol |
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CAS Registry Number | 2487-48-1 |
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IUPAC Name | (1S,2R,5S,9R,10R,11S,15S)-5,9-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-7-en-14-one |
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Traditional Name | 7b-Hydroxy-DHEA |
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SMILES | [H][C@@]12CCC(=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])[C@@H](O)C=C2C[C@@H](O)CC[C@]12C |
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InChI Identifier | InChI=1S/C19H28O3/c1-18-7-5-12(20)9-11(18)10-15(21)17-13-3-4-16(22)19(13,2)8-6-14(17)18/h10,12-15,17,20-21H,3-9H2,1-2H3/t12-,13-,14-,15-,17-,18-,19-/m0/s1 |
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InChI Key | OLPSAOWBSPXZEA-GCNMQWDSSA-N |
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Chemical Taxonomy |
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Description | belongs to the class of organic compounds known as androgens and derivatives. These are 3-hydroxylated C19 steroid hormones. They are known to favor the development of masculine characteristics. They also show profound effects on scalp and body hair in humans. |
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Kingdom | Organic compounds |
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Super Class | Lipids and lipid-like molecules |
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Class | Steroids and steroid derivatives |
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Sub Class | Androstane steroids |
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Direct Parent | Androgens and derivatives |
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Alternative Parents | |
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Substituents | - Androgen-skeleton
- 3-hydroxy-delta-5-steroid
- 3-hydroxysteroid
- 7-hydroxysteroid
- 7-alpha-hydroxysteroid
- 3-beta-hydroxysteroid
- 3-beta-hydroxy-delta-5-steroid
- Oxosteroid
- 17-oxosteroid
- Hydroxysteroid
- Delta-5-steroid
- Cyclic alcohol
- Secondary alcohol
- Ketone
- Organic oxygen compound
- Organooxygen compound
- Carbonyl group
- Hydrocarbon derivative
- Alcohol
- Organic oxide
- Aliphatic homopolycyclic compound
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Molecular Framework | Aliphatic homopolycyclic compounds |
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External Descriptors | |
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Biological Properties |
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Status | Detected and Not Quantified |
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Origin | Not Available |
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Cellular Locations | Not Available |
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Biofluid Locations | Not Available |
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Tissue Locations | Not Available |
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Pathways | Not Available |
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Applications | Not Available |
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Biological Roles | Not Available |
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Chemical Roles | Not Available |
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Physical Properties |
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State | Not Available |
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Appearance | Not Available |
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Experimental Properties | Property | Value |
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Melting Point | Not Available | Boiling Point | Not Available | Solubility | Not Available |
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Predicted Properties | |
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Spectra |
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Spectra | Spectrum Type | Description | Splash Key | View |
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Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | splash10-03g0-0390000000-5b84fc74cc8c3d885c1b | Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (2 TMS) - 70eV, Positive | splash10-001i-1735900000-cde53af4934fd251f9d9 | Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | Not Available | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-00kr-0092000000-003d307a3c381597e38b | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-0ap0-0190000000-7563041720b768705389 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0a6u-3190000000-8012f9fad41969d73d46 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-0udi-0049000000-3459db2d82d83321802f | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-0udr-0098000000-6a1aaf578c3c1719798a | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-059f-2090000000-85d4a8001358a115f59b | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-0udi-0009000000-93986d59045cc7fce551 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-0udi-0019000000-8b3060136e49afe5a336 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-0uy0-0093000000-e42b11a1c3c059294db3 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-0a4i-0069000000-61a09d88b13611d21a89 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-0670-1981000000-b0f1410f207bdaec9fa1 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-05dl-3910000000-4b2efd9d887548375fc0 | Spectrum |
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Toxicity Profile |
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Route of Exposure | Not Available |
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Mechanism of Toxicity | Not Available |
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Metabolism | Not Available |
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Toxicity Values | Not Available |
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Lethal Dose | Not Available |
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Carcinogenicity (IARC Classification) | Not Available |
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Uses/Sources | Not Available |
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Minimum Risk Level | Not Available |
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Health Effects | Not Available |
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Symptoms | Not Available |
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Treatment | Not Available |
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Concentrations |
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| Not Available |
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External Links |
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DrugBank ID | Not Available |
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HMDB ID | HMDB0004624 |
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FooDB ID | FDB023384 |
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Phenol Explorer ID | Not Available |
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KNApSAcK ID | Not Available |
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BiGG ID | Not Available |
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BioCyc ID | Not Available |
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METLIN ID | Not Available |
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PDB ID | Not Available |
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Wikipedia Link | Not Available |
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Chemspider ID | 7993704 |
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ChEBI ID | 712193 |
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PubChem Compound ID | 9817954 |
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Kegg Compound ID | Not Available |
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YMDB ID | Not Available |
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ECMDB ID | Not Available |
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References |
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Synthesis Reference | Not Available |
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MSDS | Not Available |
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General References | 1. Pouzar, Vladimir; Slavikova, Tereza; Cerny, Ivan. On Steroids. 387. Synthesis of (19E)-3b,7b-dihydroxy-17-oxoandrost-5-en-19-al 19-(O-carboxymethyl)oxime, new hapten for 7b-hydroxydehydroepiandrosterone (3b,7b-dihydroxyandrost-5-en-17-one). Collection of Czechoslovak Chemical Communications (1997), 62(1), 109-123. | 2. Pouzar, Vladimir; Slavikova, Tereza; Cerny, Ivan. On Steroids. 387. Synthesis of (19E)-3b,7b-dihydroxy-17-oxoandrost-5-en-19-al 19-(O-carboxymethyl)oxime, new hapten for 7b-hydroxydehydroepiandrosterone (3b,7b-dihydroxyandrost-5-en-17-one). Collection of Czechoslovak Chemical Communications (1997), 62(1), 109-123. | 3. Hennebert O, Chalbot S, Alran S, Morfin R: Dehydroepiandrosterone 7alpha-hydroxylation in human tissues: possible interference with type 1 11beta-hydroxysteroid dehydrogenase-mediated processes. J Steroid Biochem Mol Biol. 2007 May;104(3-5):326-33. Epub 2007 Mar 24. | 4. Robinzon B, Michael KK, Ripp SL, Winters SJ, Prough RA: Glucocorticoids inhibit interconversion of 7-hydroxy and 7-oxo metabolites of dehydroepiandrosterone: a role for 11beta-hydroxysteroid dehydrogenases? Arch Biochem Biophys. 2003 Apr 15;412(2):251-8. |
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