Record Information |
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Version | 1.0 |
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Creation Date | 2016-05-26 05:48:24 UTC |
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Update Date | 2016-11-09 01:21:19 UTC |
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Accession Number | CHEM035483 |
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Identification |
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Common Name | Prostaglandin B1 |
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Class | Small Molecule |
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Description | A member of the class of prostaglandins B that is prosta-8(12),13-dien-1-oic acid carrying oxo and hydroxy substituents at positions 9 and 15 respectively (the 13E,15S-stereoisomer). |
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Contaminant Sources | |
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Contaminant Type | Not Available |
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Chemical Structure | |
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Synonyms | Value | Source |
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PGB1 | ChEBI | (13E,15S)-15-Hydroxy-9-oxoprosta-8(12),13-dien-1-Oate | HMDB | (13E,15S)-15-Hydroxy-9-oxoprosta-8(12),13-dien-1-Oic acid | HMDB | 9-oxo-15S-Hydroxy-8(12),13E-prostadienoate | HMDB | 9-oxo-15S-Hydroxy-8(12),13E-prostadienoic acid | HMDB | Prostaglandin-b1 | HMDB | Prostaglandin b1 | MeSH |
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Chemical Formula | C20H32O4 |
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Average Molecular Mass | 336.466 g/mol |
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Monoisotopic Mass | 336.230 g/mol |
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CAS Registry Number | 13345-51-2 |
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IUPAC Name | 7-{2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopent-1-en-1-yl}heptanoic acid |
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Traditional Name | prostaglandin-B1 |
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SMILES | CCCCC[C@H](O)\C=C\C1=C(CCCCCCC(O)=O)C(=O)CC1 |
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InChI Identifier | InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 |
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InChI Key | YBHMPNRDOVPQIN-VSOYFRJCSA-N |
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Chemical Taxonomy |
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Description | belongs to the class of organic compounds known as prostaglandins and related compounds. These are unsaturated carboxylic acids consisting of a 20 carbon skeleton that also contains a five member ring, and are based upon the fatty acid arachidonic acid. |
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Kingdom | Organic compounds |
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Super Class | Lipids and lipid-like molecules |
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Class | Fatty Acyls |
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Sub Class | Eicosanoids |
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Direct Parent | Prostaglandins and related compounds |
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Alternative Parents | |
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Substituents | - Prostaglandin skeleton
- Long-chain fatty acid
- Fatty alcohol
- Hydroxy fatty acid
- Ketone
- Cyclic ketone
- Secondary alcohol
- Monocarboxylic acid or derivatives
- Carboxylic acid
- Carboxylic acid derivative
- Hydrocarbon derivative
- Alcohol
- Organic oxide
- Organic oxygen compound
- Organooxygen compound
- Carbonyl group
- Aliphatic homomonocyclic compound
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Molecular Framework | Aliphatic homomonocyclic compounds |
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External Descriptors | |
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Biological Properties |
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Status | Detected and Not Quantified |
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Origin | Not Available |
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Cellular Locations | Not Available |
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Biofluid Locations | Not Available |
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Tissue Locations | Not Available |
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Pathways | Not Available |
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Applications | Not Available |
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Biological Roles | Not Available |
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Chemical Roles | Not Available |
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Physical Properties |
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State | Not Available |
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Appearance | Not Available |
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Experimental Properties | Property | Value |
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Melting Point | Not Available | Boiling Point | Not Available | Solubility | Not Available |
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Predicted Properties | |
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Spectra |
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Spectra | Spectrum Type | Description | Splash Key | View |
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Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | splash10-05n0-5192000000-a7e9f36e25137b9fabcc | Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (2 TMS) - 70eV, Positive | splash10-010c-9126300000-342d7eee52879bb192e6 | Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | Not Available | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-0gb9-0029000000-0690d2f3dfb5d1ee9afe | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-0l6u-4495000000-96548847dc77e5ecb0dd | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-06du-9230000000-bdbc4c091593478de78b | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-000i-0019000000-af954838d61275b1a6b2 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-014r-2059000000-e381e90f103a41486292 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-0a4l-9140000000-c082f378971a61d35c10 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-0uxr-0129000000-2d428b3ff47d60ebed59 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-0uy0-6797000000-9e0090cf284a26438dc4 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0api-9400000000-79d7c252855e7c736ea6 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-014i-0029000000-877d392a3ea777176963 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-00ri-1297000000-51af315e563050950d6d | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-05tn-5930000000-05a9fe2c2833996f0a2a | Spectrum |
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Toxicity Profile |
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Route of Exposure | Not Available |
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Mechanism of Toxicity | Not Available |
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Metabolism | Not Available |
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Toxicity Values | Not Available |
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Lethal Dose | Not Available |
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Carcinogenicity (IARC Classification) | Not Available |
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Uses/Sources | Not Available |
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Minimum Risk Level | Not Available |
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Health Effects | Not Available |
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Symptoms | Not Available |
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Treatment | Not Available |
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Concentrations |
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| Not Available |
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External Links |
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DrugBank ID | Not Available |
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HMDB ID | HMDB0002982 |
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FooDB ID | FDB023088 |
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Phenol Explorer ID | Not Available |
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KNApSAcK ID | Not Available |
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BiGG ID | Not Available |
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BioCyc ID | Not Available |
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METLIN ID | 408 |
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PDB ID | Not Available |
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Wikipedia Link | Not Available |
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Chemspider ID | 4444076 |
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ChEBI ID | 27624 |
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PubChem Compound ID | 5280388 |
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Kegg Compound ID | C00959 |
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YMDB ID | Not Available |
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ECMDB ID | M2MDB005507 |
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References |
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Synthesis Reference | Not Available |
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MSDS | Not Available |
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General References | 1. Hishinuma T, Nakamura H, Itoh K, Ohyama Y, Ishibashi M, Mizugaki M: Microdetermination of the prostaglandin B1 in human plasma by gas chromatography/selected ion monitoring using [18O]prostaglandin B1 as an internal standard. Prostaglandins. 1995 Apr;49(4):239-46. | 2. Fry MR, Ghosh SS, East JM, Franson RC: Role of human sperm phospholipase A2 in fertilization: effects of a novel inhibitor of phospholipase A2 activity on membrane perturbations and oocyte penetration. Biol Reprod. 1992 Nov;47(5):751-9. | 3. Franson R, Raghupathi R, Fry M, Saal J, Vishwanath B, Ghosh SS, Rosenthal MD: Inhibition of human phospholipases A2 by cis-unsaturated fatty acids and oligomers of prostaglandin B1. Adv Exp Med Biol. 1990;279:219-30. | 4. Franson RC, Rosenthal MD: Oligomers of prostaglandin B1 inhibit in vitro phospholipase A2 activity. Biochim Biophys Acta. 1989 Dec 18;1006(3):272-7. | 5. Himori N, Burkman AM: Prostaglandin B1 can modify the pressor responses to sympathetic nerve stimulation. Res Commun Chem Pathol Pharmacol. 1983 Sep;41(3):397-405. |
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