Iodate (CHEM035054)

IdentificationTaxonomyBiological PropertiesPhysical PropertiesToxicity ProfileSpectraConcentrationsLinksReferencesXML
Record Information
Version1.0
Creation Date2016-05-26 05:27:05 UTC
Update Date2016-11-09 01:21:14 UTC
Accession NumberCHEM035054
Identification
Common NameIodate
ClassSmall Molecule
DescriptionIodate is an iodate is a salt of iodic acid. Because it is more stable than iodide, most health authorities preferentially recommend iodate as an additive to salt for correcting iodine deficiency. Even in a low exposure, doubts have been raised whether the safety of iodate. In humans and rats, oral bioavailability of iodine from iodate is virtually equivalent to that from iodide. When given intravenously to rats, or when added to whole blood or tissue homogenates in vitro or to foodstuff, iodate is quantitatively reduced to iodide by nonenzymatic reactions, and thus becomes available to the body as iodide. Therefore, except perhaps for the gastrointestinal mucosa, exposure of tissues to iodate might be minimal. At much higher doses given intravenously (i.e., above 10 mg/kg), iodate is highly toxic to the retina. Ocular toxicity in humans has occurred only after exposure to doses of 600 to 1,200 mg per individual. Oral exposures of several animal species to high doses, exceeding the human intake from fortified salt by orders of magnitude, pointed to corrosive effects in the gastrointestinal tract, hemolysis, nephrotoxicity, and hepatic injury. Genotoxicity and carcinogenicity data for iodate are scarce or nonexistent. (PMID: 11396703).
Contaminant Sources
  • FooDB Chemicals
Contaminant TypeNot Available
Chemical Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms
ValueSource
Iodic acidGenerator
[IO3](-)HMDB
IO3(-)HMDB
Iodate (I2O62-)HMDB
Iodate (io3(1-))HMDB
Iodate anionHMDB
Iodate ionHMDB
Iodate ion (io31-)HMDB
Iodate(1-)HMDB
Iodic acid (hio3) ion(1-)HMDB
Trioxidoiodate(1-)HMDB
Chemical FormulaIO3
Average Molecular Mass174.903 g/mol
Monoisotopic Mass174.889 g/mol
CAS Registry Number15454-31-6
IUPAC Nametrihydroxyiodanediium
Traditional Nametrihydroxyiodanediium
SMILES[O-][I](=O)=O
InChI IdentifierInChI=1S/HIO3/c2-1(3)4/h(H,2,3,4)/p-1
InChI KeyICIWUVCWSCSTAQ-UHFFFAOYSA-M
Chemical Taxonomy
Description belongs to the class of inorganic compounds known as other non-metal halides. These are inorganic compounds containing 'other non-metals' and halogen.
KingdomInorganic compounds
Super ClassHomogeneous non-metal compounds
ClassOther non-metal halides
Sub ClassNot Available
Direct ParentOther non-metal halides
Alternative ParentsNot Available
Substituents
  • Other non-metal halide
Molecular FrameworkNot Available
External DescriptorsNot Available
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
PathwaysNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted Properties
PropertyValueSource
Physiological Charge2ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area60.69 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity21.03 m³·mol⁻¹ChemAxon
Polarizability9.38 ųChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
SpectraNot Available
Toxicity Profile
Route of ExposureNot Available
Mechanism of ToxicityNot Available
MetabolismNot Available
Toxicity ValuesNot Available
Lethal DoseNot Available
Carcinogenicity (IARC Classification)Not Available
Uses/SourcesNot Available
Minimum Risk LevelNot Available
Health EffectsNot Available
SymptomsNot Available
TreatmentNot Available
Concentrations
Not Available
DrugBank IDNot Available
HMDB IDHMDB0001061
FooDB IDFDB022400
Phenol Explorer IDNot Available
KNApSAcK IDNot Available
BiGG IDNot Available
BioCyc IDNot Available
METLIN IDNot Available
PDB IDNot Available
Wikipedia LinkIodate
Chemspider ID76615
ChEBI ID29226
PubChem Compound ID84927
Kegg Compound IDNot Available
YMDB IDNot Available
ECMDB IDNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General References
1. Scrabal, A.; Gruber, Josef. Halogenoxy compounds. XII. Kinetics of the formation of iodate from iodine in presence of triiodide ion. Monatshefte fuer Chemie (1917), 37 535-48.
2. Czepita D: [The possibilities of using the newest experimental results in the progressive myopia treatment]. Klin Oczna. 1999;101(2):145-7.
3. Burgi H, Schaffner TH, Seiler JP: The toxicology of iodate: a review of the literature. Thyroid. 2001 May;11(5):449-56.
4. Wu T, Liu GJ, Li P, Clar C: Iodised salt for preventing iodine deficiency disorders. Cochrane Database Syst Rev. 2002;(3):CD003204.
5. von Gunten U: Ozonation of drinking water: part II. Disinfection and by-product formation in presence of bromide, iodide or chlorine. Water Res. 2003 Apr;37(7):1469-87.
6. Kalk WJ: Iodine deficiency disorders in South Africa. S Afr Med J. 1998 Mar;88(3 Endocrinology):352-4.
7. Angermayr L, Clar C: Iodine supplementation for preventing iodine deficiency disorders in children. Cochrane Database Syst Rev. 2004;(2):CD003819.
8. Genc Y, Humphries JM, Lyons GH, Graham RD: Exploiting genotypic variation in plant nutrient accumulation to alleviate micronutrient deficiency in populations. J Trace Elem Med Biol. 2005;18(4):319-24.
9. Scrimshaw NS: Fifty-five-year personal experience with human nutrition worldwide. Annu Rev Nutr. 2007;27:1-18.
10. Ulbricht W: The inactivation of sodium channels in the node of Ranvier and its chemical modification. Ion Channels. 1990;2:123-68.
11. Khubaveshki S, Lozanov B: [Current problems in the pathogenesis and treatment of endemic goiter]. Vutr Boles. 1990;29(5):7-13.
12. Burgos FJ, Teruel JL, Mayayo T, Lovaco F, Berenguer A, Orte L, Tallada M, Ortuno J: Diagnosis and management of lymphoceles after renal transplantation. Br J Urol. 1988 Apr;61(4):289-93.
13. Korte GE, Perlman JI, Pollack A: Regeneration of mammalian retinal pigment epithelium. Int Rev Cytol. 1994;152:223-63.
14. Cinotti A, Guandalini A, Besutti A, Mannella P: [A volumetric increase in the submandibular glands due to an organic iodate contrast medium. A case report]. Radiol Med. 1993 Jan-Feb;85(1-2):138-40.