Record Information |
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Version | 1.0 |
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Creation Date | 2016-05-26 05:24:05 UTC |
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Update Date | 2016-11-09 01:21:13 UTC |
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Accession Number | CHEM034992 |
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Identification |
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Common Name | Androstanedione |
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Class | Small Molecule |
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Description | |
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Contaminant Sources | |
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Contaminant Type | Not Available |
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Chemical Structure | |
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Synonyms | Value | Source |
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5alpha-Androstan-3,17-dione | ChEBI | 5a-Androstan-3,17-dione | Generator | 5Α-androstan-3,17-dione | Generator | (5a)-Androstane-3,17-dione | HMDB | 5-alpha-Androstane-3,17-dione | HMDB | 5a-Androsta-3,17-dione | HMDB | 5a-Androstane-3, 17-dione | HMDB | 5a-Androstane-3,17-dione | HMDB | 5a-Androstanedione | HMDB | 5alpha-Androstane-3,17-dione | HMDB | Androstane-3,17-dione | HMDB | Androstane-3,7-dione | HMDB | Androstane-3,17-dione, (2-3(H)-labeled, (2beta,5beta))-isomer | HMDB | Androstane-3,17-dione, (4-(3)H-labeled, (4alpha,5beta))-isomer | HMDB | Androstane-3,17-dione, (2-3(H)-labeled, (2alpha,5beta))-isomer | HMDB | Androstane-3,17-dione, (4-(3)H-labeled, (4beta,5beta))-isomer | HMDB | Androstane-3,17-dione, (5beta)-isomer | HMDB | 3,17-Dioxy-5 alpha-androstane | HMDB | 5 alpha-Androstanedione | HMDB | 5 beta-Androstane-3,17-dione | HMDB | 5 alpha-Androstane-3,17-dione | HMDB | Androstane-3,17-dione, (5alpha)-isomer | HMDB |
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Chemical Formula | C19H28O2 |
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Average Molecular Mass | 288.424 g/mol |
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Monoisotopic Mass | 288.209 g/mol |
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CAS Registry Number | 846-46-8 |
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IUPAC Name | (1S,2S,7S,10R,11S,15S)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecane-5,14-dione |
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Traditional Name | (1S,2S,7S,10R,11S,15S)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecane-5,14-dione |
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SMILES | [H][C@@]12CCC(=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])CC(=O)CC[C@]12C |
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InChI Identifier | InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 |
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InChI Key | RAJWOBJTTGJROA-WZNAKSSCSA-N |
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Chemical Taxonomy |
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Description | belongs to the class of organic compounds known as androgens and derivatives. These are 3-hydroxylated C19 steroid hormones. They are known to favor the development of masculine characteristics. They also show profound effects on scalp and body hair in humans. |
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Kingdom | Organic compounds |
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Super Class | Lipids and lipid-like molecules |
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Class | Steroids and steroid derivatives |
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Sub Class | Androstane steroids |
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Direct Parent | Androgens and derivatives |
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Alternative Parents | |
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Substituents | - Androgen-skeleton
- 3-oxo-5-alpha-steroid
- Oxosteroid
- 17-oxosteroid
- 3-oxosteroid
- Cyclic ketone
- Ketone
- Organic oxygen compound
- Organic oxide
- Hydrocarbon derivative
- Organooxygen compound
- Carbonyl group
- Aliphatic homopolycyclic compound
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Molecular Framework | Aliphatic homopolycyclic compounds |
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External Descriptors | |
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Biological Properties |
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Status | Detected and Not Quantified |
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Origin | Not Available |
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Cellular Locations | Not Available |
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Biofluid Locations | Not Available |
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Tissue Locations | Not Available |
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Pathways | Not Available |
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Applications | Not Available |
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Biological Roles | Not Available |
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Chemical Roles | Not Available |
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Physical Properties |
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State | Not Available |
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Appearance | Not Available |
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Experimental Properties | Property | Value |
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Melting Point | Not Available | Boiling Point | Not Available | Solubility | Not Available |
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Predicted Properties | |
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Spectra |
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Spectra | Spectrum Type | Description | Splash Key | View |
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GC-MS | GC-MS Spectrum - GC-MS (Non-derivatized) | splash10-003u-9711000000-845e34a01c44999f2ded | Spectrum | GC-MS | GC-MS Spectrum - EI-B (Non-derivatized) | splash10-000i-2790000000-3265da77fd4cc7bfa1c9 | Spectrum | GC-MS | GC-MS Spectrum - GC-MS (Non-derivatized) | splash10-003u-9711000000-845e34a01c44999f2ded | Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | splash10-03ea-0490000000-e4819053bc47c4809a6c | Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | Not Available | Spectrum | LC-MS/MS | LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated) | splash10-000i-0090000000-decf354145d0bc46e624 | Spectrum | LC-MS/MS | LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated) | splash10-01vk-4910000000-1f05b00fe5f61dd134c3 | Spectrum | LC-MS/MS | LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated) | splash10-05ng-9800000000-ef0555e1d54150aaffd2 | Spectrum | LC-MS/MS | LC-MS/MS Spectrum - Linear Ion Trap , negative | splash10-0aou-0290000000-ffd1b454b311f471cb73 | Spectrum | LC-MS/MS | LC-MS/MS Spectrum - Linear Ion Trap , positive | splash10-014i-0390000000-f4995b2047bec58846f5 | Spectrum | LC-MS/MS | LC-MS/MS Spectrum - Linear Ion Trap , positive | splash10-00di-0390000000-a4cf943964aae2cffee6 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-000i-0190000000-8b26abdeab6d06d616e3 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-05a9-0490000000-5411cf1f548c371b71f5 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0mkg-2690000000-fd3043c5fcf860949b79 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-000i-0090000000-be391ca3b57229eb2b28 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-000i-0090000000-0c9ee67f63fb1f48c00a | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-052f-3190000000-4d4ec5ab2ebbcfdebbd0 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-000i-0090000000-a3a5ee5e1cdb4d550aac | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-0h90-0970000000-66d8653b98d2df4aa327 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0a4i-1900000000-2a46c86775b66edae018 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-000i-0090000000-383f8ad782110ec64fbf | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-000i-0090000000-383f8ad782110ec64fbf | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-0f79-0090000000-0497207bd4a67a50d8d8 | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 2D NMR | [1H,13C] 2D NMR Spectrum | Not Available | Spectrum |
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Toxicity Profile |
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Route of Exposure | Not Available |
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Mechanism of Toxicity | Not Available |
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Metabolism | Not Available |
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Toxicity Values | Not Available |
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Lethal Dose | Not Available |
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Carcinogenicity (IARC Classification) | Not Available |
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Uses/Sources | Not Available |
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Minimum Risk Level | Not Available |
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Health Effects | Not Available |
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Symptoms | Not Available |
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Treatment | Not Available |
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Concentrations |
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| Not Available |
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External Links |
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DrugBank ID | DB01561 |
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HMDB ID | HMDB0000899 |
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FooDB ID | FDB022307 |
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Phenol Explorer ID | Not Available |
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KNApSAcK ID | Not Available |
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BiGG ID | 42505 |
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BioCyc ID | CPD-342 |
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METLIN ID | 5855 |
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PDB ID | Not Available |
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Wikipedia Link | Androstanedione |
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Chemspider ID | 193520 |
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ChEBI ID | 15994 |
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PubChem Compound ID | 222865 |
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Kegg Compound ID | C00674 |
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YMDB ID | Not Available |
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ECMDB ID | M2MDB005066 |
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References |
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Synthesis Reference | Not Available |
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MSDS | Not Available |
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General References | 1. Marker, Russell E.; Kamm, Oliver; Jones, David M.; Oakwood, Thomas S. Sterols. VIII. Preparation of androstanedione from allopregnanediol. Journal of the American Chemical Society (1937), 59 614-16. | 2. Marker, Russell E.; Kamm, Oliver; Jones, David M.; Oakwood, Thomas S. Sterols. VIII. Preparation of androstanedione from allopregnanediol. Journal of the American Chemical Society (1937), 59 614-16. | 3. Gonzalez-Santos MR, Gaja-Rodriguez OV, Alonso-Uriarte R, Sojo-Aranda I, Cortes-Gallegos V: Sleep deprivation and adaptive hormonal responses of healthy men. Arch Androl. 1989;22(3):203-7. | 4. Karlsson T, Vahlquist A, Kedishvili N, Torma H: 13-cis-retinoic acid competitively inhibits 3 alpha-hydroxysteroid oxidation by retinol dehydrogenase RoDH-4: a mechanism for its anti-androgenic effects in sebaceous glands? Biochem Biophys Res Commun. 2003 Mar 28;303(1):273-8. | 5. https://www.ncbi.nlm.nih.gov/pubmed/?term=22064602 | 6. https://www.ncbi.nlm.nih.gov/pubmed/?term=3702464 |
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