Record Information |
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Version | 1.0 |
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Creation Date | 2016-05-26 00:22:08 UTC |
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Update Date | 2016-11-09 01:18:39 UTC |
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Accession Number | CHEM028309 |
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Identification |
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Common Name | Thiolutin |
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Class | Small Molecule |
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Description | A dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 4,5 and 6 have been replaced by methyl, oxo and acetamido groups, respectively. It is a potent inhibitor of RNA polymerases, inhibits the angiogenesis of human umbilical vein endothelial cells, and also inhibits JAMM metalloproteases. |
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Contaminant Sources | |
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Contaminant Type | Not Available |
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Chemical Structure | |
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Synonyms | Value | Source |
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6-Acetamido-4-methyl-1,2-dithiolo[4,3-b]pyrrol-5(4H)-one | ChEBI | Acetopyrrothin | ChEBI | Acetopyrrothine | ChEBI | N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide | ChEBI | N-(4-Methyl-5-oxodithiolo[4,3-b]pyrrol-6-yl)acetamide | ChEBI | Farcinicine | HMDB | N-Acetylpyrrothine | HMDB | N-{4-methyl-5-oxo-4H,5H-[1,2]dithiolo[4,3-b]pyrrol-6-yl}ethanimidate | Generator | Thiolutin | MeSH |
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Chemical Formula | C8H8N2O2S2 |
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Average Molecular Mass | 228.291 g/mol |
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Monoisotopic Mass | 228.003 g/mol |
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CAS Registry Number | 87-11-6 |
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IUPAC Name | N-{4-methyl-5-oxo-4H,5H-[1,2]dithiolo[4,3-b]pyrrol-6-yl}acetamide |
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Traditional Name | thiolutin |
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SMILES | CN1C(=O)C(NC(C)=O)=C2SSC=C12 |
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InChI Identifier | InChI=1S/C8H8N2O2S2/c1-4(11)9-6-7-5(3-13-14-7)10(2)8(6)12/h3H,1-2H3,(H,9,11) |
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InChI Key | MHMRAFONCSQAIA-UHFFFAOYSA-N |
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Chemical Taxonomy |
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Description | belongs to the class of organic compounds known as n-acetylarylamines. These are acetamides where one or more amide hydrogens is substituted by an aryl group. |
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Kingdom | Organic compounds |
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Super Class | Organic nitrogen compounds |
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Class | Organonitrogen compounds |
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Sub Class | N-arylamides |
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Direct Parent | N-acetylarylamines |
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Alternative Parents | |
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Substituents | - N-acetylarylamine
- N-methylpyrrole
- Substituted pyrrole
- Pyrrole
- 1,2-dithiole
- Dithiole
- Acetamide
- Heteroaromatic compound
- Carboxamide group
- Secondary carboxylic acid amide
- Lactam
- Organoheterocyclic compound
- Carboxylic acid derivative
- Azacycle
- Carbonyl group
- Organopnictogen compound
- Organooxygen compound
- Organic oxygen compound
- Hydrocarbon derivative
- Organic oxide
- Aromatic heteropolycyclic compound
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Molecular Framework | Aromatic heteropolycyclic compounds |
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External Descriptors | Not Available |
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Biological Properties |
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Status | Detected and Not Quantified |
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Origin | Not Available |
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Cellular Locations | Not Available |
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Biofluid Locations | Not Available |
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Tissue Locations | Not Available |
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Pathways | Not Available |
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Applications | Not Available |
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Biological Roles | Not Available |
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Chemical Roles | Not Available |
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Physical Properties |
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State | Not Available |
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Appearance | Not Available |
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Experimental Properties | Property | Value |
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Melting Point | Not Available | Boiling Point | Not Available | Solubility | Not Available |
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Predicted Properties | |
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Spectra |
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Spectra | Spectrum Type | Description | Splash Key | View |
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Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | splash10-054o-3910000000-519ee727a019d3a93d69 | Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | Not Available | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-004i-7590000000-85817f7eb87b0115bd93 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-004r-0590000000-515631cb29113ba3b962 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-052s-9200000000-f7ff9dbd9f3a2082f78f | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-004i-0890000000-9e6266701a4ec9c61060 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-003r-1970000000-03b1d843e3d93fbf40bc | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-0zgi-2900000000-2d15a380d25bc120cdf3 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-002r-0980000000-5f26834e99b886e3f03b | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-002r-0960000000-7693ffa3bb0a88d601d7 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0159-2900000000-a10fda5b87d577f08ad2 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-004i-0090000000-95faf19c58c835a83e00 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-0059-0590000000-0ab84e20d5f22fd4f7af | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-004i-1920000000-229b3b69617b7784c357 | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum |
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Toxicity Profile |
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Route of Exposure | Not Available |
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Mechanism of Toxicity | Not Available |
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Metabolism | Not Available |
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Toxicity Values | Not Available |
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Lethal Dose | Not Available |
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Carcinogenicity (IARC Classification) | Not Available |
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Uses/Sources | Not Available |
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Minimum Risk Level | Not Available |
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Health Effects | Not Available |
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Symptoms | Not Available |
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Treatment | Not Available |
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Concentrations |
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| Not Available |
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External Links |
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DrugBank ID | Not Available |
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HMDB ID | HMDB0034228 |
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FooDB ID | FDB012539 |
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Phenol Explorer ID | Not Available |
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KNApSAcK ID | C00054277 |
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BiGG ID | Not Available |
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BioCyc ID | CPD-17934 |
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METLIN ID | Not Available |
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PDB ID | Not Available |
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Wikipedia Link | Thiolutin |
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Chemspider ID | 6608 |
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ChEBI ID | 156450 |
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PubChem Compound ID | 6870 |
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Kegg Compound ID | Not Available |
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YMDB ID | Not Available |
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ECMDB ID | Not Available |
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References |
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Synthesis Reference | Not Available |
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MSDS | Not Available |
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General References | 1. https://www.ncbi.nlm.nih.gov/pubmed/?term=11433393 | 2. https://www.ncbi.nlm.nih.gov/pubmed/?term=17036064 | 3. https://www.ncbi.nlm.nih.gov/pubmed/?term=17914747 | 4. https://www.ncbi.nlm.nih.gov/pubmed/?term=18720982 | 5. https://www.ncbi.nlm.nih.gov/pubmed/?term=19579057 | 6. https://www.ncbi.nlm.nih.gov/pubmed/?term=2262169 | 7. https://www.ncbi.nlm.nih.gov/pubmed/?term=24723205 | 8. https://www.ncbi.nlm.nih.gov/pubmed/?term=25353334 | 9. https://www.ncbi.nlm.nih.gov/pubmed/?term=28459440 | 10. https://www.ncbi.nlm.nih.gov/pubmed/?term=31601735 | 11. https://www.ncbi.nlm.nih.gov/pubmed/?term=32049520 | 12. https://www.ncbi.nlm.nih.gov/pubmed/?term=4583213 | 13. https://www.ncbi.nlm.nih.gov/pubmed/?term=4597739 | 14. https://www.ncbi.nlm.nih.gov/pubmed/?term=4604615 | 15. https://www.ncbi.nlm.nih.gov/pubmed/?term=6758684 | 16. https://www.ncbi.nlm.nih.gov/pubmed/?term=775314 | 17. https://www.ncbi.nlm.nih.gov/pubmed/?term=793624 | 18. Dai S, Jia Y, Wu SL, Isenberg JS, Ridnour LA, Bandle RW, Wink DA, Roberts DD, Karger BL: Comprehensive characterization of heat shock protein 27 phosphorylation in human endothelial cells stimulated by the microbial dithiole thiolutin. J Proteome Res. 2008 Oct;7(10):4384-95. doi: 10.1021/pr800376w. Epub 2008 Aug 23. | 19. Yannai, Shmuel. (2004) Dictionary of food compounds with CD-ROM: Additives, flavors, and ingredients. Boca Raton: Chapman & Hall/CRC. |
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