Record Information |
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Version | 1.0 |
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Creation Date | 2016-05-25 18:23:41 UTC |
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Update Date | 2016-11-09 01:17:26 UTC |
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Accession Number | CHEM022203 |
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Identification |
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Common Name | Cyclobenzaprine |
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Class | Small Molecule |
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Description | Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961 and has been available for human use since 1977. It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from by only a single double bond. Since its approval, it has remained relatively popular as an adjunctive, short-term treatment for acute skeletal muscle spasms secondary to musculoskeletal injury. |
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Contaminant Sources | - HMDB Contaminants - Urine
- STOFF IDENT Compounds
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Contaminant Type | Not Available |
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Chemical Structure | |
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Synonyms | Value | Source |
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(3-Dibenzo[a,D]cyclohepten-5-ylidene-propyl)-dimethyl-amine | ChEBI | Ciclobenzaprina | ChEBI | Cyclobenzaprinum | ChEBI | N,N-Dimethyl-5H-dibenzo(a,D)cycloheptene-Delta(5,gamma)-propylamine | ChEBI | N,N-Dimethyl-5H-dibenzo(a,D)cycloheptene-delta(5,g)-propylamine | Generator | N,N-Dimethyl-5H-dibenzo(a,D)cycloheptene-δ(5,γ)-propylamine | Generator | N,N-Dimethyl-5H-dibenzo(a,D)cycloheptene-δ(5,g)-propylamine | HMDB | Cyclobenzaprine HCL | HMDB | Flexeril | HMDB | Lisseril | HMDB | Cyclobenzaprine hydrochloride | HMDB |
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Chemical Formula | C20H21N |
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Average Molecular Mass | 275.387 g/mol |
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Monoisotopic Mass | 275.167 g/mol |
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CAS Registry Number | 303-53-7 |
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IUPAC Name | dimethyl(3-{tricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,9,11,13-heptaen-2-ylidene}propyl)amine |
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Traditional Name | cyclobenzaprine |
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SMILES | CN(C)CCC=C1C2=CC=CC=C2C=CC2=CC=CC=C12 |
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InChI Identifier | InChI=1S/C20H21N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-14H,7,15H2,1-2H3 |
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InChI Key | JURKNVYFZMSNLP-UHFFFAOYSA-N |
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Chemical Taxonomy |
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Description | belongs to the class of organic compounds known as dibenzocycloheptenes. Dibenzocycloheptenes are compounds containing a dibenzocycloheptene moiety, which consists of two benzene rings connected by a cycloheptene ring. |
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Kingdom | Organic compounds |
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Super Class | Benzenoids |
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Class | Dibenzocycloheptenes |
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Sub Class | Not Available |
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Direct Parent | Dibenzocycloheptenes |
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Alternative Parents | |
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Substituents | - Dibenzocycloheptene
- Tertiary aliphatic amine
- Tertiary amine
- Organic nitrogen compound
- Organopnictogen compound
- Hydrocarbon derivative
- Organonitrogen compound
- Amine
- Aromatic homopolycyclic compound
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Molecular Framework | Aromatic homopolycyclic compounds |
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External Descriptors | |
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Biological Properties |
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Status | Detected and Not Quantified |
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Origin | Not Available |
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Cellular Locations | Not Available |
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Biofluid Locations | Not Available |
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Tissue Locations | Not Available |
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Pathways | Not Available |
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Applications | Not Available |
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Biological Roles | Not Available |
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Chemical Roles | Not Available |
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Physical Properties |
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State | Not Available |
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Appearance | Not Available |
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Experimental Properties | Property | Value |
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Melting Point | Not Available | Boiling Point | Not Available | Solubility | Not Available |
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Predicted Properties | |
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Spectra |
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Spectra | Spectrum Type | Description | Splash Key | View |
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Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | splash10-0a4i-9040000000-6d92a6b3b68f574cfa96 | Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | Not Available | Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | Not Available | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-004i-0090000000-b82bb6864d1db9590238 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-003r-2190000000-d7ca012a9442c5c5159d | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0f6x-9860000000-d6cd399a2bc4bff340b6 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-00di-0090000000-2ec20dd7f67cc51c9e31 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-00di-1090000000-6688ebb97b5d79eca312 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-002f-7290000000-87d189310c604e77fbc2 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-004i-0090000000-93624eb06b890930f701 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-004i-0090000000-204146569caae8c2b6be | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0a4i-3090000000-443350b9631b31aaa21c | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-00di-0090000000-639559d845843ccd499a | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-00di-0090000000-96cd6df79ac93f81d7ae | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-014i-0090000000-e16ad7a8e7b878d6be95 | Spectrum |
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Toxicity Profile |
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Route of Exposure | Not Available |
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Mechanism of Toxicity | Not Available |
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Metabolism | Not Available |
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Toxicity Values | Not Available |
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Lethal Dose | Not Available |
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Carcinogenicity (IARC Classification) | Not Available |
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Uses/Sources | Not Available |
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Minimum Risk Level | Not Available |
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Health Effects | Not Available |
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Symptoms | Not Available |
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Treatment | Not Available |
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Concentrations |
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| Not Available |
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External Links |
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DrugBank ID | DB00924 |
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HMDB ID | HMDB0015060 |
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FooDB ID | Not Available |
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Phenol Explorer ID | Not Available |
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KNApSAcK ID | Not Available |
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BiGG ID | Not Available |
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BioCyc ID | Not Available |
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METLIN ID | Not Available |
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PDB ID | Not Available |
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Wikipedia Link | Cyclobenzaprine |
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Chemspider ID | 2792 |
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ChEBI ID | 3996 |
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PubChem Compound ID | 2895 |
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Kegg Compound ID | C06931 |
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YMDB ID | Not Available |
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ECMDB ID | Not Available |
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References |
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Synthesis Reference | Not Available |
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MSDS | Not Available |
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General References | |
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