Record Information |
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Version | 1.0 |
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Creation Date | 2016-05-22 06:44:50 UTC |
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Update Date | 2016-11-09 01:16:07 UTC |
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Accession Number | CHEM020062 |
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Identification |
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Common Name | Proglumetacin |
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Class | Small Molecule |
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Description | A carboxylic ester obtained by formal condensation of the carboxy group of indometacin with the hydroxy group of 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl N(2)-benzoyl-N,N-dipropyl-alpha-glutaminate. Used (as its dimaleate salt) to control pain and inflammation associated with musculoskeletal and joint disorders. Following oral administration, it is metabolised to indometacin and proglumide, a drug with antisecretory effects that helps prevent injury to the stomach lining. |
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Contaminant Sources | - STOFF IDENT Compounds
- ToxCast & Tox21 Chemicals
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Contaminant Type | Not Available |
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Chemical Structure | |
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Synonyms | Value | Source |
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Proglumetacina | ChEBI | Proglumetacine | ChEBI | Proglumetacinum | ChEBI | Bruxel | Kegg | 3-[4-[2-[2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-benzamido-5-(dipropylamino)-5-oxopentanoic acid | Generator | Proglumetacin maleate | MeSH | Protaxil | MeSH | Proglumetacin | MeSH | 3'-(4-(2-(1-P-Chlorobenzoyl-5-methoxy-2-methylindol-3-ylacetoxy)ethyl)piperazin-1-yl)propyl-4-benzamido-N,N-dipropylglutaramate (+-) dimaleate | MeSH | Protaxon | MeSH | Prodamox | MeSH | Proglumetacin dimaleate | MeSH | Protacine | MeSH |
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Chemical Formula | C46H58ClN5O8 |
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Average Molecular Mass | 844.450 g/mol |
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Monoisotopic Mass | 843.397 g/mol |
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CAS Registry Number | 57132-53-3 |
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IUPAC Name | N-[4-(3-{4-[2-({2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl}oxy)ethyl]piperazin-1-yl}propoxy)-1-(dipropylcarbamoyl)-4-oxobutyl]benzenecarboximidic acid |
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Traditional Name | proglumetacin |
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SMILES | CCCN(CCC)C(=O)C(CCC(=O)OCCCN1CCN(CCOC(=O)CC2=C(C)N(C(=O)C3=CC=C(Cl)C=C3)C3=C2C=C(OC)C=C3)CC1)N=C(O)C1=CC=CC=C1 |
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InChI Identifier | InChI=1S/C46H58ClN5O8/c1-5-21-51(22-6-2)46(57)40(48-44(55)34-11-8-7-9-12-34)18-20-42(53)59-29-10-23-49-24-26-50(27-25-49)28-30-60-43(54)32-38-33(3)52(41-19-17-37(58-4)31-39(38)41)45(56)35-13-15-36(47)16-14-35/h7-9,11-17,19,31,40H,5-6,10,18,20-30,32H2,1-4H3,(H,48,55) |
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InChI Key | PTXGHCGBYMQQIG-UHFFFAOYSA-N |
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Chemical Taxonomy |
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Description | belongs to the class of organic compounds known as benzoylindoles. These are organic compounds containing an indole attached to a benzoyl moiety through the acyl group. |
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Kingdom | Organic compounds |
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Super Class | Organoheterocyclic compounds |
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Class | Indoles and derivatives |
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Sub Class | Benzoylindoles |
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Direct Parent | Benzoylindoles |
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Alternative Parents | |
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Substituents | - Benzoylindole
- Glutamic acid or derivatives
- N-acyl-alpha amino acid or derivatives
- Indole-3-acetic acid derivative
- Alpha-amino acid amide
- Indolecarboxylic acid derivative
- Alpha-amino acid or derivatives
- 4-halobenzoic acid or derivatives
- Halobenzoic acid or derivatives
- 3-alkylindole
- Indole
- Benzoic acid or derivatives
- Benzoyl
- Anisole
- Chlorobenzene
- N-alkylpiperazine
- Alkyl aryl ether
- Fatty acid ester
- Halobenzene
- Aryl chloride
- Aryl halide
- Monocyclic benzene moiety
- Fatty acyl
- 1,4-diazinane
- Dicarboxylic acid or derivatives
- Benzenoid
- N-acyl-amine
- Piperazine
- Substituted pyrrole
- Pyrrole
- Tertiary carboxylic acid amide
- Heteroaromatic compound
- Tertiary aliphatic amine
- Tertiary amine
- Amino acid or derivatives
- Carboxylic acid ester
- Carboxamide group
- Propargyl-type 1,3-dipolar organic compound
- Organic 1,3-dipolar compound
- Ether
- Carboxylic acid derivative
- Carboximidic acid derivative
- Carboximidic acid
- Azacycle
- Organopnictogen compound
- Carbonyl group
- Hydrocarbon derivative
- Amine
- Organic nitrogen compound
- Organic oxide
- Organohalogen compound
- Organochloride
- Organonitrogen compound
- Organooxygen compound
- Organic oxygen compound
- Aromatic heteropolycyclic compound
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Molecular Framework | Aromatic heteropolycyclic compounds |
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External Descriptors | |
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Biological Properties |
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Status | Detected and Not Quantified |
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Origin | Not Available |
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Cellular Locations | Not Available |
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Biofluid Locations | Not Available |
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Tissue Locations | Not Available |
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Pathways | Not Available |
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Applications | Not Available |
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Biological Roles | Not Available |
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Chemical Roles | Not Available |
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Physical Properties |
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State | Not Available |
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Appearance | Not Available |
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Experimental Properties | Property | Value |
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Melting Point | Not Available | Boiling Point | Not Available | Solubility | Not Available |
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Predicted Properties | |
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Spectra |
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Spectra | Spectrum Type | Description | Splash Key | View |
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Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-0006-2409330370-19666391c0e8952af68f | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-06r6-3809130100-4fbcd1a37e958a4f9558 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0006-9302010100-efc6163b9b6be0eeb3b5 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-00ku-0009110030-b53a613b0e8b503682fb | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-0fs9-0439110210-faf3ec9036dd23476d8d | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-05bv-9747200510-9f4318692332d37050a8 | Spectrum |
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Toxicity Profile |
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Route of Exposure | Not Available |
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Mechanism of Toxicity | Not Available |
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Metabolism | Not Available |
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Toxicity Values | Not Available |
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Lethal Dose | Not Available |
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Carcinogenicity (IARC Classification) | Not Available |
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Uses/Sources | Not Available |
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Minimum Risk Level | Not Available |
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Health Effects | Not Available |
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Symptoms | Not Available |
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Treatment | Not Available |
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Concentrations |
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| Not Available |
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External Links |
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DrugBank ID | DB13527 |
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HMDB ID | HMDB0256795 |
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FooDB ID | Not Available |
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Phenol Explorer ID | Not Available |
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KNApSAcK ID | Not Available |
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BiGG ID | Not Available |
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BioCyc ID | Not Available |
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METLIN ID | Not Available |
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PDB ID | Not Available |
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Wikipedia Link | Proglumetacin |
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Chemspider ID | 4752 |
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ChEBI ID | 76263 |
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PubChem Compound ID | Not Available |
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Kegg Compound ID | Not Available |
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YMDB ID | Not Available |
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ECMDB ID | Not Available |
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References |
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Synthesis Reference | Not Available |
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MSDS | Not Available |
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General References | |
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