Record Information |
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Version | 1.0 |
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Creation Date | 2016-05-22 05:58:42 UTC |
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Update Date | 2016-11-09 01:15:57 UTC |
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Accession Number | CHEM019279 |
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Identification |
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Common Name | Clobetasone butyrate |
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Class | Small Molecule |
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Description | Clobetasone butyrate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. |
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Contaminant Sources | - ToxCast & Tox21 Chemicals
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Contaminant Type | Not Available |
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Chemical Structure | |
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Synonyms | Value | Source |
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Kindavate | Kegg | Kindavic acid | Generator | Clobetasone butyric acid | Generator | Emovate | MeSH | Eumovate | MeSH | 21-Chloro-11-dehydro-betamethasone-17-butyrate | MeSH | Clobetasone 17-butyrate | MeSH | Trimovate | MeSH | [(8S,9R,10S,13S,14S,16S,17R)-17-(2-Chloroacetyl)-9-fluoro-10,13,16-trimethyl-3,11-dioxo-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-17-yl] butanoic acid | Generator | Clobetasone butyrate | MeSH | (1R,2S,10S,11S,13S,14R,15S)-14-(2-Chloroacetyl)-1-fluoro-2,13,15-trimethyl-5,17-dioxotetracyclo[8.7.0.0,.0,]heptadeca-3,6-dien-14-yl butanoic acid | Generator |
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Chemical Formula | C26H32ClFO5 |
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Average Molecular Mass | 478.990 g/mol |
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Monoisotopic Mass | 478.192 g/mol |
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CAS Registry Number | 25122-57-0 |
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IUPAC Name | (1R,2S,10S,11S,13S,14R,15S)-14-(2-chloroacetyl)-1-fluoro-2,13,15-trimethyl-5,17-dioxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-14-yl butanoate |
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Traditional Name | eumovate |
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SMILES | [H][C@]1(C)C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)C(=O)C[C@]2(C)[C@@]1(OC(=O)CCC)C(=O)CCl |
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InChI Identifier | InChI=1S/C26H32ClFO5/c1-5-6-22(32)33-26(21(31)14-27)15(2)11-19-18-8-7-16-12-17(29)9-10-23(16,3)25(18,28)20(30)13-24(19,26)4/h9-10,12,15,18-19H,5-8,11,13-14H2,1-4H3/t15-,18-,19-,23-,24-,25-,26-/m0/s1 |
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InChI Key | FBRAWBYQGRLCEK-AVVSTMBFSA-N |
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Chemical Taxonomy |
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Description | belongs to the class of organic compounds known as gluco/mineralocorticoids, progestogins and derivatives. These are steroids with a structure based on a hydroxylated prostane moiety. |
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Kingdom | Organic compounds |
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Super Class | Lipids and lipid-like molecules |
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Class | Steroids and steroid derivatives |
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Sub Class | Pregnane steroids |
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Direct Parent | Gluco/mineralocorticoids, progestogins and derivatives |
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Alternative Parents | |
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Substituents | - Progestogin-skeleton
- Steroid ester
- 20-oxosteroid
- 3-oxo-delta-1,4-steroid
- 3-oxosteroid
- Oxosteroid
- 11-oxosteroid
- 9-halo-steroid
- Halo-steroid
- Delta-1,4-steroid
- Alpha-acyloxy ketone
- Alpha-haloketone
- Alpha-chloroketone
- Carboxylic acid ester
- Cyclic ketone
- Ketone
- Carboxylic acid derivative
- Monocarboxylic acid or derivatives
- Organochloride
- Organofluoride
- Organooxygen compound
- Hydrocarbon derivative
- Organic oxygen compound
- Carbonyl group
- Alkyl halide
- Alkyl fluoride
- Alkyl chloride
- Organohalogen compound
- Organic oxide
- Aliphatic homopolycyclic compound
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Molecular Framework | Aliphatic homopolycyclic compounds |
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External Descriptors | Not Available |
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Biological Properties |
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Status | Detected and Not Quantified |
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Origin | Not Available |
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Cellular Locations | Not Available |
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Biofluid Locations | Not Available |
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Tissue Locations | Not Available |
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Pathways | Not Available |
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Applications | Not Available |
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Biological Roles | Not Available |
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Chemical Roles | Not Available |
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Physical Properties |
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State | Not Available |
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Appearance | Not Available |
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Experimental Properties | Property | Value |
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Melting Point | Not Available | Boiling Point | Not Available | Solubility | Not Available |
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Predicted Properties | |
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Spectra |
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Spectra | Spectrum Type | Description | Splash Key | View |
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Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-00b9-3002900000-c535c6e5487bece71a4c | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-00di-9055500000-aef02efc78118216f17b | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-00fr-5379100000-6ed23daf7ce864339750 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-004i-2001900000-3e19bbd4ec0f67ee465b | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-0ay3-6006900000-b2f04288519573615e5d | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-05vx-9008100000-0001e44246c4082f681a | Spectrum |
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Toxicity Profile |
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Route of Exposure | Not Available |
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Mechanism of Toxicity | Not Available |
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Metabolism | Not Available |
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Toxicity Values | Not Available |
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Lethal Dose | Not Available |
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Carcinogenicity (IARC Classification) | Not Available |
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Uses/Sources | Not Available |
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Minimum Risk Level | Not Available |
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Health Effects | Not Available |
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Symptoms | Not Available |
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Treatment | Not Available |
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Concentrations |
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| Not Available |
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External Links |
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DrugBank ID | DBSALT001967 |
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HMDB ID | Not Available |
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FooDB ID | Not Available |
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Phenol Explorer ID | Not Available |
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KNApSAcK ID | Not Available |
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BiGG ID | Not Available |
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BioCyc ID | Not Available |
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METLIN ID | Not Available |
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PDB ID | Not Available |
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Wikipedia Link | Clobetasone butyrate |
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Chemspider ID | Not Available |
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ChEBI ID | Not Available |
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PubChem Compound ID | 71386 |
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Kegg Compound ID | Not Available |
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YMDB ID | Not Available |
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ECMDB ID | Not Available |
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References |
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Synthesis Reference | Not Available |
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MSDS | Not Available |
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General References | Not Available |
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