Record Information |
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Version | 1.0 |
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Creation Date | 2016-05-22 05:41:03 UTC |
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Update Date | 2016-11-09 01:15:53 UTC |
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Accession Number | CHEM018937 |
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Identification |
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Common Name | Levonordefrin |
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Class | Small Molecule |
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Description | A catecholamine in which the 2-aminoethyl group is substituted with a hydroxy group at C-1 and a methyl group at C-2, with configurations 1R,2S. A metabolite of alpha-methyl-L-dopa, it is an alpha2-adrenergic agonist and acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry. |
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Contaminant Sources | - HMDB Contaminants - Urine
- ToxCast & Tox21 Chemicals
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Contaminant Type | Not Available |
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Chemical Structure | |
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Synonyms | Value | Source |
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alpha-(1-Aminoethyl)-3,4-dihydroxybenzyl alcohol | ChEBI | alpha-Methylnorepinephrine | ChEBI | Corbadrina | ChEBI | Corbadrine | ChEBI | Corbadrinum | ChEBI | Isoadrenaline | ChEBI | Methylnoradrenaline | ChEBI | alpha-Methylnoradrenaline | Kegg | Neo-cobefrin | Kegg | a-(1-Aminoethyl)-3,4-dihydroxybenzyl alcohol | Generator | Α-(1-aminoethyl)-3,4-dihydroxybenzyl alcohol | Generator | a-Methylnorepinephrine | Generator | Α-methylnorepinephrine | Generator | a-Methylnoradrenaline | Generator | Α-methylnoradrenaline | Generator | 4-(2-Amino-1-hydroxypropyl)-1,2-benzenediol, (r*,r*)-isomer | HMDB | 4-(2-Amino-1-hydroxypropyl)-1,2-benzenediol, (r*,s*)-isomer | HMDB | Neo cobefrin | HMDB | Nordefrin hydrochloride, (r*,s*)-(+,-)-isomer | HMDB | Nordefrin tartrate, (r*,s*), (r*,r*) isomer | HMDB | 3,4 Dihydroxynorephedrine | HMDB | Hydrochloride, nordefrin | HMDB | Nordefrin | HMDB | Nordefrin hydrochloride | HMDB | Nordefrin tartrate, (r*,r*), (r*,r*) isomer | HMDB | Nordefrin, (r*,s*)-isomer | HMDB | alpha Methylnoradrenaline | HMDB | alpha Methylnorepinephrine | HMDB | 4-(2-Amino-1-hydroxypropyl)-1,2-benzenediol hydrochloride, (r*,r*)-(+,-)-isomer | HMDB | 4-(2-Amino-1-hydroxypropyl)-1,2-benzenediol tartrate, (r*,r*), (r*,r*)-isomer | HMDB | 4-(2-Amino-1-hydroxypropyl)-1,2-benzenediol tartrate, (r*,s*), (r*,r*)-isomer | HMDB | NeoCobefrin | HMDB | Nordefrin hydrochloride, (r*,r*)-(+,-)-isomer | HMDB | Nordefrin, (r*,r*)-isomer | HMDB | 3,4-Dihydroxynorephedrine | HMDB | 4-(2-Amino-1-hydroxypropyl)-1,2-benzenediol | HMDB | 4-(2-Amino-1-hydroxypropyl)-1,2-benzenediol hydrochloride, (r*,s*)-(+-)-isomer | HMDB | Cobefrine | HMDB | Methylnorepinephrine | HMDB | Norephrine | HMDB | Levonordefrin | ChEBI |
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Chemical Formula | C9H13NO3 |
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Average Molecular Mass | 183.204 g/mol |
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Monoisotopic Mass | 183.090 g/mol |
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CAS Registry Number | 829-74-3 |
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IUPAC Name | 4-[(1R,2S)-2-amino-1-hydroxypropyl]benzene-1,2-diol |
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Traditional Name | levonordefrin |
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SMILES | C[C@H](N)[C@H](O)C1=CC(O)=C(O)C=C1 |
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InChI Identifier | InChI=1S/C9H13NO3/c1-5(10)9(13)6-2-3-7(11)8(12)4-6/h2-5,9,11-13H,10H2,1H3/t5-,9-/m0/s1 |
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InChI Key | GEFQWZLICWMTKF-CDUCUWFYSA-N |
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Chemical Taxonomy |
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Description | belongs to the class of organic compounds known as phenylpropanes. These are organic compounds containing a phenylpropane moiety. |
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Kingdom | Organic compounds |
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Super Class | Benzenoids |
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Class | Benzene and substituted derivatives |
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Sub Class | Phenylpropanes |
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Direct Parent | Phenylpropanes |
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Alternative Parents | |
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Substituents | - Phenylpropane
- Catechol
- 1-hydroxy-4-unsubstituted benzenoid
- 1-hydroxy-2-unsubstituted benzenoid
- Phenol
- Aralkylamine
- 1,2-aminoalcohol
- Secondary alcohol
- Organic nitrogen compound
- Aromatic alcohol
- Primary amine
- Hydrocarbon derivative
- Organopnictogen compound
- Organooxygen compound
- Organonitrogen compound
- Primary aliphatic amine
- Organic oxygen compound
- Amine
- Alcohol
- Aromatic homomonocyclic compound
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Molecular Framework | Aromatic homomonocyclic compounds |
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External Descriptors | |
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Biological Properties |
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Status | Detected and Not Quantified |
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Origin | Not Available |
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Cellular Locations | Not Available |
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Biofluid Locations | Not Available |
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Tissue Locations | Not Available |
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Pathways | Not Available |
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Applications | Not Available |
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Biological Roles | Not Available |
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Chemical Roles | Not Available |
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Physical Properties |
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State | Not Available |
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Appearance | Not Available |
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Experimental Properties | Property | Value |
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Melting Point | Not Available | Boiling Point | Not Available | Solubility | Not Available |
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Predicted Properties | |
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Spectra |
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Spectra | Spectrum Type | Description | Splash Key | View |
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Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | splash10-000f-9700000000-97a66276892b2b9a6d84 | Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (3 TMS) - 70eV, Positive | splash10-03di-4493000000-9bd4051e22d9ba138050 | Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | Not Available | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-0159-0900000000-bca9b4d25388d07c977f | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-014j-0900000000-5eda894ad9ec103325cf | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0zfs-5900000000-2e7d4302e50276d6779d | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-001i-0900000000-f0b8ebb5e32926cf168e | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-01qi-0900000000-affe67c3772699b13b41 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-0a4i-2900000000-98e0e5a67c5da9331891 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-014i-0900000000-fb62819bff82a937e5bc | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-00kb-2900000000-ef244b4a084824e097b1 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0uk9-9600000000-8e21565f2276bece257e | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-01x0-0900000000-4d329ca34072b59eedd4 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-00di-0900000000-f3d6884a1d9a0b402eb9 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-0596-9800000000-0a42555edab27c646a52 | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum |
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Toxicity Profile |
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Route of Exposure | Not Available |
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Mechanism of Toxicity | Not Available |
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Metabolism | Not Available |
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Toxicity Values | Not Available |
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Lethal Dose | Not Available |
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Carcinogenicity (IARC Classification) | Not Available |
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Uses/Sources | Not Available |
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Minimum Risk Level | Not Available |
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Health Effects | Not Available |
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Symptoms | Not Available |
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Treatment | Not Available |
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Concentrations |
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| Not Available |
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External Links |
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DrugBank ID | DB06707 |
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HMDB ID | HMDB0015652 |
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FooDB ID | Not Available |
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Phenol Explorer ID | Not Available |
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KNApSAcK ID | Not Available |
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BiGG ID | Not Available |
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BioCyc ID | Not Available |
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METLIN ID | Not Available |
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PDB ID | Not Available |
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Wikipedia Link | Corbadrine |
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Chemspider ID | 144416 |
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ChEBI ID | 141146 |
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PubChem Compound ID | 164739 |
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Kegg Compound ID | C11768 |
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YMDB ID | Not Available |
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ECMDB ID | Not Available |
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References |
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Synthesis Reference | Not Available |
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MSDS | Not Available |
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General References | |
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