Record Information |
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Version | 1.0 |
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Creation Date | 2016-05-22 05:15:51 UTC |
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Update Date | 2016-11-09 01:15:48 UTC |
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Accession Number | CHEM018456 |
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Identification |
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Common Name | Diflorasone diacetate |
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Class | Small Molecule |
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Description | The 17,21-diacetate derivative of diflorasone. It is used topically for its anti-inflammatory and antipruritic properties in the treatment of various skin disorders. |
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Contaminant Sources | - ToxCast & Tox21 Chemicals
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Contaminant Type | Not Available |
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Chemical Structure | |
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Synonyms | Value | Source |
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(6alpha,11beta,16beta)-6,9-Difluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl diacetate | ChEBI | 6alpha,9-Difluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-diacetate | ChEBI | Diflorasone 17,21-diacetate | ChEBI | Diflorasone di(acetate) | ChEBI | Florone | Kegg | Psorcon | Kegg | (6a,11b,16b)-6,9-Difluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl diacetate | Generator | (6a,11b,16b)-6,9-Difluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl diacetic acid | Generator | (6alpha,11beta,16beta)-6,9-Difluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl diacetic acid | Generator | (6Α,11β,16β)-6,9-difluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl diacetate | Generator | (6Α,11β,16β)-6,9-difluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl diacetic acid | Generator | 6a,9-Difluoro-11b,17,21-trihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17,21-diacetate | Generator | 6a,9-Difluoro-11b,17,21-trihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17,21-diacetic acid | Generator | 6alpha,9-Difluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-diacetic acid | Generator | 6Α,9-difluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-diacetate | Generator | 6Α,9-difluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-diacetic acid | Generator | Diflorasone 17,21-diacetic acid | Generator | Diflorasone di(acetic acid) | Generator | Diflorasone diacetic acid | Generator | Allergan brand OF diflorasone diacetate | MeSH | Dermik brand 1 OF diflorasone diacetate | MeSH | Dermik brand 2 OF diflorasone diacetate | MeSH | Dermik brand 3 OF diflorasone diacetate | MeSH | Flutone | MeSH | Galderma brand OF diflorasone diacetate | MeSH | Maxiflor | MeSH | Psorcon e | MeSH | Rhône-poulenc rorer brand OF diflorasone diacetate | MeSH | Diflorasone | MeSH |
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Chemical Formula | C26H32F2O7 |
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Average Molecular Mass | 494.532 g/mol |
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Monoisotopic Mass | 494.212 g/mol |
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CAS Registry Number | 33564-31-7 |
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IUPAC Name | 2-[(1R,2S,8S,10S,11S,13S,14R,15S,17S)-14-(acetyloxy)-1,8-difluoro-17-hydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-14-yl]-2-oxoethyl acetate |
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Traditional Name | diflorasone |
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SMILES | [H][C@]1(C)C[C@@]2([H])[C@]3([H])C[C@]([H])(F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@]([H])(O)C[C@]2(C)[C@@]1(OC(C)=O)C(=O)COC(C)=O |
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InChI Identifier | InChI=1S/C26H32F2O7/c1-13-8-17-18-10-20(27)19-9-16(31)6-7-23(19,4)25(18,28)21(32)11-24(17,5)26(13,35-15(3)30)22(33)12-34-14(2)29/h6-7,9,13,17-18,20-21,32H,8,10-12H2,1-5H3/t13-,17-,18-,20-,21-,23-,24-,25-,26-/m0/s1 |
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InChI Key | BOBLHFUVNSFZPJ-JOYXJVLSSA-N |
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Chemical Taxonomy |
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Description | belongs to the class of organic compounds known as gluco/mineralocorticoids, progestogins and derivatives. These are steroids with a structure based on a hydroxylated prostane moiety. |
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Kingdom | Organic compounds |
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Super Class | Lipids and lipid-like molecules |
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Class | Steroids and steroid derivatives |
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Sub Class | Pregnane steroids |
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Direct Parent | Gluco/mineralocorticoids, progestogins and derivatives |
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Alternative Parents | |
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Substituents | - Progestogin-skeleton
- Steroid ester
- 20-oxosteroid
- 3-oxo-delta-1,4-steroid
- 3-oxosteroid
- 11-hydroxysteroid
- 11-beta-hydroxysteroid
- Oxosteroid
- 9-halo-steroid
- 6-halo-steroid
- Halo-steroid
- Hydroxysteroid
- Delta-1,4-steroid
- Alpha-acyloxy ketone
- Dicarboxylic acid or derivatives
- Cyclic alcohol
- Carboxylic acid ester
- Cyclic ketone
- Secondary alcohol
- Fluorohydrin
- Ketone
- Halohydrin
- Carboxylic acid derivative
- Alcohol
- Organic oxide
- Hydrocarbon derivative
- Organic oxygen compound
- Carbonyl group
- Organooxygen compound
- Organofluoride
- Organohalogen compound
- Alkyl fluoride
- Alkyl halide
- Aliphatic homopolycyclic compound
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Molecular Framework | Aliphatic homopolycyclic compounds |
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External Descriptors | |
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Biological Properties |
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Status | Detected and Not Quantified |
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Origin | Not Available |
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Cellular Locations | Not Available |
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Biofluid Locations | Not Available |
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Tissue Locations | Not Available |
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Pathways | Not Available |
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Applications | Not Available |
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Biological Roles | Not Available |
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Chemical Roles | Not Available |
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Physical Properties |
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State | Not Available |
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Appearance | Not Available |
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Experimental Properties | Property | Value |
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Melting Point | Not Available | Boiling Point | Not Available | Solubility | Not Available |
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Predicted Properties | |
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Spectra |
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Spectra | Spectrum Type | Description | Splash Key | View |
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LC-MS/MS | LC-MS/MS Spectrum - LC-ESI-qTof , Positive | splash10-03dl-2900000000-a43198a76493a4d0f488 | Spectrum | LC-MS/MS | LC-MS/MS Spectrum - , positive | splash10-0229-3981000000-c09d67334820aee3d8c1 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-0f9b-0000900000-998ab7f97e632d00c2d6 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-000l-0024900000-49b251f065e3ba78874d | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-03fu-2096000000-72bcbe9522a234f249a1 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-052f-7001900000-c42e38c398cf9c804d07 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-0a4i-9002300000-ba79bd1174489fbeb95c | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-0a4i-9002000000-a8c43d975d42cecb6a8e | Spectrum |
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Toxicity Profile |
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Route of Exposure | Not Available |
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Mechanism of Toxicity | Not Available |
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Metabolism | Not Available |
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Toxicity Values | Not Available |
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Lethal Dose | Not Available |
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Carcinogenicity (IARC Classification) | Not Available |
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Uses/Sources | Not Available |
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Minimum Risk Level | Not Available |
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Health Effects | Not Available |
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Symptoms | Not Available |
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Treatment | Not Available |
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Concentrations |
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| Not Available |
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External Links |
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DrugBank ID | DBSALT000887 |
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HMDB ID | Not Available |
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FooDB ID | Not Available |
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Phenol Explorer ID | Not Available |
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KNApSAcK ID | Not Available |
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BiGG ID | Not Available |
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BioCyc ID | Not Available |
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METLIN ID | Not Available |
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PDB ID | Not Available |
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Wikipedia Link | Diflorasone diacetate |
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Chemspider ID | Not Available |
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ChEBI ID | 31483 |
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PubChem Compound ID | Not Available |
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Kegg Compound ID | Not Available |
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YMDB ID | Not Available |
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ECMDB ID | Not Available |
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References |
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Synthesis Reference | Not Available |
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MSDS | Not Available |
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General References | Not Available |
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