Record Information |
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Version | 1.0 |
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Creation Date | 2016-05-22 05:15:16 UTC |
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Update Date | 2016-11-09 01:15:48 UTC |
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Accession Number | CHEM018435 |
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Identification |
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Common Name | Nicergoline |
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Class | Small Molecule |
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Description | An ergot derivative that has been used as a cerebral vasodilator and in peripheral vascular disease. It has been suggested to ameliorate cognitive deficits in cerebrovascular disease. |
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Contaminant Sources | - HMDB Contaminants - Urine
- STOFF IDENT Compounds
- ToxCast & Tox21 Chemicals
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Contaminant Type | Not Available |
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Chemical Structure | |
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Synonyms | Value | Source |
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Sermion | Kegg | Circo-maren | HMDB | Dexcel brand OF nicergoline | HMDB | Nicergolin atid | HMDB | Nicergolin lindo | HMDB | Nicergolin-neuraxpharm | HMDB | Nicergoline hexal brand | HMDB | Nicerium | HMDB | Nicotergoline | HMDB | Pfizer brand OF nicergoline | HMDB | Teva brand OF nicergoline | HMDB | CT Arzneimittel brand OF nicergoline | HMDB | Neuraxpharm brand OF nicergoline | HMDB | Ratiopharm brand OF nicergoline | HMDB | Circo maren | HMDB | Fisifax | HMDB | Hormosan brand OF nicergoline | HMDB | Nicergobeta | HMDB | Nicergolin neuraxpharm | HMDB | Nicergolin-ratiopharm | HMDB | Nicergoline pfizer brand | HMDB | Nicergoline teva brand | HMDB | Reig jofre brand OF nicergoline | HMDB | Aventis brand OF nicergoline | HMDB | F.I. 6714 | HMDB | Hexal brand OF nicergoline | HMDB | Lindopharm brand OF nicergoline | HMDB | Nicergolin-teva | HMDB | Betapharm brand OF nicergoline | HMDB | Kenfarma brand OF nicergoline | HMDB | Krewel brand OF nicergoline | HMDB | Nicergolin teva | HMDB | Nicergolin ratiopharm | HMDB | Nimergoline | HMDB | CT-Arzneimittel brand OF nicergoline | HMDB | Ergobel | HMDB | Nicergolin von CT | HMDB | Von CT, nicergolin | HMDB |
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Chemical Formula | C24H26BrN3O3 |
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Average Molecular Mass | 484.386 g/mol |
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Monoisotopic Mass | 483.116 g/mol |
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CAS Registry Number | 27848-84-6 |
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IUPAC Name | [(2S,4R,7R)-2-methoxy-6,11-dimethyl-6,11-diazatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadeca-1(16),9,12,14-tetraen-4-yl]methyl 5-bromopyridine-3-carboxylate |
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Traditional Name | nicergoline |
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SMILES | [H][C@@]12CC3=CN(C)C4=CC=CC(=C34)[C@]1(C[C@@H](COC(=O)C1=CC(Br)=CN=C1)CN2C)OC |
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InChI Identifier | InChI=1S/C24H26BrN3O3/c1-27-13-17-8-21-24(30-3,19-5-4-6-20(27)22(17)19)9-15(12-28(21)2)14-31-23(29)16-7-18(25)11-26-10-16/h4-7,10-11,13,15,21H,8-9,12,14H2,1-3H3/t15-,21-,24+/m1/s1 |
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InChI Key | YSEXMKHXIOCEJA-FVFQAYNVSA-N |
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Chemical Taxonomy |
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Description | belongs to the class of organic compounds known as indoloquinolines. These are polycyclic aromatic compounds containing an indole fused to a quinoline. |
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Kingdom | Organic compounds |
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Super Class | Organoheterocyclic compounds |
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Class | Quinolines and derivatives |
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Sub Class | Indoloquinolines |
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Direct Parent | Indoloquinolines |
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Alternative Parents | |
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Substituents | - Ergoline skeleton
- Indoloquinoline
- Benzoquinoline
- Pyrroloquinoline
- N-alkylindole
- 3-alkylindole
- Indole
- Indole or derivatives
- Isoindole or derivatives
- Pyridine carboxylic acid
- Alkaloid or derivatives
- Pyridine carboxylic acid or derivatives
- Aralkylamine
- Aryl bromide
- Aryl halide
- N-methylpyrrole
- Piperidine
- Benzenoid
- Pyridine
- Substituted pyrrole
- Pyrrole
- Heteroaromatic compound
- Tertiary amine
- Tertiary aliphatic amine
- Amino acid or derivatives
- Carboxylic acid ester
- Carboxylic acid derivative
- Azacycle
- Monocarboxylic acid or derivatives
- Dialkyl ether
- Ether
- Amine
- Organopnictogen compound
- Organic oxygen compound
- Organic oxide
- Hydrocarbon derivative
- Organohalogen compound
- Organic nitrogen compound
- Organobromide
- Organonitrogen compound
- Organooxygen compound
- Aromatic heteropolycyclic compound
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Molecular Framework | Aromatic heteropolycyclic compounds |
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External Descriptors | Not Available |
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Biological Properties |
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Status | Detected and Not Quantified |
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Origin | Not Available |
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Cellular Locations | Not Available |
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Biofluid Locations | Not Available |
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Tissue Locations | Not Available |
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Pathways | Not Available |
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Applications | Not Available |
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Biological Roles | Not Available |
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Chemical Roles | Not Available |
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Physical Properties |
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State | Not Available |
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Appearance | Not Available |
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Experimental Properties | Property | Value |
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Melting Point | Not Available | Boiling Point | Not Available | Solubility | Not Available |
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Predicted Properties | |
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Spectra |
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Spectra | Spectrum Type | Description | Splash Key | View |
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Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | splash10-01oy-0490000000-9946900f54448caef05c | Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | Not Available | Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | Not Available | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-001i-0070900000-31a0fe890dfcef178a8d | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-001i-0090200000-e7257eb7542660c9b4c7 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0pc0-2390000000-90dd1884dd9a2c36f452 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-001i-0110900000-1589cacb0deaf8363131 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-0532-0920500000-513d6a319962dbf7cbf3 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-0a4j-0920000000-330babe951e9ccb2384a | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-0udi-0000900000-2649cd14eb52b3a4655b | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-001i-0000900000-a0efe44d5c8b6301ef53 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0udi-0391000000-906dc143d70f8ce61d0e | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-001i-0000900000-b7c2f66e57ef37412e1a | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-003r-4100900000-fe5f17d8fb6e1a206cbd | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-0a6r-2900100000-a189dad93ea9944c264f | Spectrum |
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Toxicity Profile |
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Route of Exposure | Not Available |
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Mechanism of Toxicity | Not Available |
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Metabolism | Not Available |
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Toxicity Values | Not Available |
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Lethal Dose | Not Available |
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Carcinogenicity (IARC Classification) | Not Available |
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Uses/Sources | Not Available |
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Minimum Risk Level | Not Available |
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Health Effects | Not Available |
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Symptoms | Not Available |
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Treatment | Not Available |
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Concentrations |
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| Not Available |
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External Links |
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DrugBank ID | DB00699 |
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HMDB ID | HMDB0014837 |
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FooDB ID | Not Available |
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Phenol Explorer ID | Not Available |
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KNApSAcK ID | Not Available |
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BiGG ID | Not Available |
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BioCyc ID | Not Available |
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METLIN ID | Not Available |
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PDB ID | Not Available |
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Wikipedia Link | Nicergoline |
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Chemspider ID | 31373 |
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ChEBI ID | Not Available |
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PubChem Compound ID | 34040 |
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Kegg Compound ID | Not Available |
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YMDB ID | Not Available |
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ECMDB ID | Not Available |
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References |
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Synthesis Reference | Not Available |
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MSDS | Not Available |
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General References | |
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