Record Information |
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Version | 1.0 |
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Creation Date | 2016-05-22 04:41:00 UTC |
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Update Date | 2016-11-09 01:15:40 UTC |
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Accession Number | CHEM017834 |
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Identification |
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Common Name | Metergoline |
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Class | Small Molecule |
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Description | An ergoline alkaloid that is the N-benzyloxycarbonyl derivative of lysergamine. A 5-HT2 antagonist. Also 5-HT1 antagonist and 5-HT1D ligand. Has moderate affinity for 5-HT6 and high affinity for 5-HT7. |
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Contaminant Sources | - STOFF IDENT Compounds
- ToxCast & Tox21 Chemicals
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Contaminant Type | Not Available |
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Chemical Structure | |
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Synonyms | Value | Source |
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(((8-beta)-1,6-Dimethylergolin-8-yl)methyl)carbamic acid benzyl ester | ChEBI | (((8-beta)-1,6-Dimethylergolin-8-yl)methyl)carbamic acid phenylmethyl ester | ChEBI | (+)-N-(Carboxy)-1-methyl-9,10-dihydrolysergamine benzyl ester | ChEBI | 1,6-Dimethyl-8-beta-carbobenzyloxaminomethyl-10-alpha-ergoline | ChEBI | 1-Methyl-8-beta-carbobenzyloxyaminomethyl-10-alpha-ergoline | ChEBI | 1-Methyl-N-carbobenzyloxydihydro-D-lysergamin | ChEBI | D-8-beta-((Carbobenzoxyamino)methyl)-1,6-dimethyl-10-alpha-ergoline | ChEBI | D-8-beta-((Carboxyamino)methyl)-1,6-dimethylergoline benzyl ester | ChEBI | Metergolin | ChEBI | Metergolina | ChEBI | Metergolinum | ChEBI | (((8-b)-1,6-Dimethylergolin-8-yl)methyl)carbamate benzyl ester | Generator | (((8-b)-1,6-Dimethylergolin-8-yl)methyl)carbamic acid benzyl ester | Generator | (((8-beta)-1,6-Dimethylergolin-8-yl)methyl)carbamate benzyl ester | Generator | (((8-Β)-1,6-dimethylergolin-8-yl)methyl)carbamate benzyl ester | Generator | (((8-Β)-1,6-dimethylergolin-8-yl)methyl)carbamic acid benzyl ester | Generator | (((8-b)-1,6-Dimethylergolin-8-yl)methyl)carbamate phenylmethyl ester | Generator | (((8-b)-1,6-Dimethylergolin-8-yl)methyl)carbamic acid phenylmethyl ester | Generator | (((8-beta)-1,6-Dimethylergolin-8-yl)methyl)carbamate phenylmethyl ester | Generator | (((8-Β)-1,6-dimethylergolin-8-yl)methyl)carbamate phenylmethyl ester | Generator | (((8-Β)-1,6-dimethylergolin-8-yl)methyl)carbamic acid phenylmethyl ester | Generator | 1,6-Dimethyl-8-b-carbobenzyloxaminomethyl-10-a-ergoline | Generator | 1,6-Dimethyl-8-β-carbobenzyloxaminomethyl-10-α-ergoline | Generator | 1-Methyl-8-b-carbobenzyloxyaminomethyl-10-a-ergoline | Generator | 1-Methyl-8-β-carbobenzyloxyaminomethyl-10-α-ergoline | Generator | D-8-b-((Carbobenzoxyamino)methyl)-1,6-dimethyl-10-a-ergoline | Generator | D-8-Β-((carbobenzoxyamino)methyl)-1,6-dimethyl-10-α-ergoline | Generator | D-8-b-((Carboxyamino)methyl)-1,6-dimethylergoline benzyl ester | Generator | D-8-Β-((carboxyamino)methyl)-1,6-dimethylergoline benzyl ester | Generator | Metergoline teofarma brand | MeSH | Liserdol | MeSH | Methergoline | MeSH | Teofarma brand OF metergoline | MeSH |
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Chemical Formula | C25H29N3O2 |
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Average Molecular Mass | 403.526 g/mol |
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Monoisotopic Mass | 403.226 g/mol |
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CAS Registry Number | 17692-51-2 |
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IUPAC Name | N-{[(2R,4R,7R)-6,11-dimethyl-6,11-diazatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadeca-1(16),9,12,14-tetraen-4-yl]methyl}(benzyloxy)carboximidic acid |
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Traditional Name | methergoline |
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SMILES | [H][C@]1(CN=C(O)OCC2=CC=CC=C2)CN(C)[C@]2([H])CC3=CN(C)C4=CC=CC(=C34)[C@@]2([H])C1 |
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InChI Identifier | InChI=1S/C25H29N3O2/c1-27-14-18(13-26-25(29)30-16-17-7-4-3-5-8-17)11-21-20-9-6-10-22-24(20)19(12-23(21)27)15-28(22)2/h3-10,15,18,21,23H,11-14,16H2,1-2H3,(H,26,29)/t18-,21+,23+/m0/s1 |
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InChI Key | WZHJKEUHNJHDLS-QTGUNEKASA-N |
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Chemical Taxonomy |
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Description | belongs to the class of organic compounds known as indoloquinolines. These are polycyclic aromatic compounds containing an indole fused to a quinoline. |
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Kingdom | Organic compounds |
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Super Class | Organoheterocyclic compounds |
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Class | Quinolines and derivatives |
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Sub Class | Indoloquinolines |
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Direct Parent | Indoloquinolines |
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Alternative Parents | |
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Substituents | - Ergoline skeleton
- Indoloquinoline
- Benzoquinoline
- Pyrroloquinoline
- Benzyloxycarbonyl
- N-alkylindole
- 3-alkylindole
- Indole
- Indole or derivatives
- Isoindole or derivatives
- Alkaloid or derivatives
- Aralkylamine
- Benzenoid
- Monocyclic benzene moiety
- N-methylpyrrole
- Substituted pyrrole
- Piperidine
- Heteroaromatic compound
- Carbamic acid ester
- Pyrrole
- Carbonic acid derivative
- Tertiary amine
- Tertiary aliphatic amine
- Azacycle
- Organonitrogen compound
- Organic oxide
- Amine
- Organopnictogen compound
- Carbonyl group
- Organic oxygen compound
- Organic nitrogen compound
- Organooxygen compound
- Hydrocarbon derivative
- Aromatic heteropolycyclic compound
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Molecular Framework | Aromatic heteropolycyclic compounds |
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External Descriptors | |
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Biological Properties |
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Status | Detected and Not Quantified |
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Origin | Not Available |
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Cellular Locations | Not Available |
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Biofluid Locations | Not Available |
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Tissue Locations | Not Available |
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Pathways | Not Available |
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Applications | Not Available |
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Biological Roles | Not Available |
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Chemical Roles | Not Available |
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Physical Properties |
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State | Not Available |
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Appearance | Not Available |
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Experimental Properties | Property | Value |
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Melting Point | Not Available | Boiling Point | Not Available | Solubility | Not Available |
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Predicted Properties | |
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Spectra |
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Spectra | Spectrum Type | Description | Splash Key | View |
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LC-MS/MS | LC-MS/MS Spectrum - LC-ESI-qTof , Positive | splash10-0ir0-4794200000-d04091d908ab86f9807e | Spectrum | LC-MS/MS | LC-MS/MS Spectrum - , positive | splash10-0ir0-4794200000-d04091d908ab86f9807e | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-0uxr-0191300000-4835b4de6449fef92fac | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-0fr6-3190000000-0d779d001d5c1019b1e7 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-01bi-1490000000-2c9b03a38c2e1316c36b | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-0006-1290200000-b57626c1f72345f0dc0f | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-0006-9370000000-56877b695eaa70a67a42 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-002f-9470000000-a8cb594fb31952430f98 | Spectrum |
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Toxicity Profile |
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Route of Exposure | Not Available |
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Mechanism of Toxicity | Not Available |
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Metabolism | Not Available |
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Toxicity Values | Not Available |
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Lethal Dose | Not Available |
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Carcinogenicity (IARC Classification) | Not Available |
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Uses/Sources | Not Available |
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Minimum Risk Level | Not Available |
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Health Effects | Not Available |
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Symptoms | Not Available |
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Treatment | Not Available |
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Concentrations |
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| Not Available |
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External Links |
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DrugBank ID | DB13520 |
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HMDB ID | Not Available |
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FooDB ID | Not Available |
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Phenol Explorer ID | Not Available |
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KNApSAcK ID | Not Available |
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BiGG ID | Not Available |
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BioCyc ID | Not Available |
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METLIN ID | Not Available |
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PDB ID | Not Available |
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Wikipedia Link | Metergoline |
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Chemspider ID | Not Available |
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ChEBI ID | 64216 |
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PubChem Compound ID | 28693 |
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Kegg Compound ID | Not Available |
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YMDB ID | Not Available |
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ECMDB ID | Not Available |
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References |
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Synthesis Reference | Not Available |
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MSDS | Not Available |
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General References | |
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