Dasatinib (CHEM017626)

IdentificationTaxonomyBiological PropertiesPhysical PropertiesToxicity ProfileSpectraConcentrationsLinksReferencesTargets (52)XML
Record Information
Version1.0
Creation Date2016-05-22 04:30:09 UTC
Update Date2026-08-21 22:25:15 UTC
Accession NumberCHEM017626
Identification
Common NameDasatinib
ClassSmall Molecule
DescriptionDasatinib is an organic compound with the chemical formula C22H26ClN7O2S and an average molecular weight of 488.01 g/mol. Dasatinib belongs to the anilides, a subclass of benzene and substituted derivatives within the organic compounds. This compound is identified as being found in or released from five recorded sources. These include electrical and electronic equipment, specifically line transmission systems and electric hearing aids, as well as household cleaning and consumer products, including pipe accessories and non-electric simulated smoking devices. Additionally, it is found in healthcare, pharmaceuticals, and veterinary products as an antineoplastic agent. The recorded route of exposure for this substance is oral. Dasatinib acts upon 23 recorded protein targets. It functions as an antagonist, binder, or inhibitor, and is characterized as a multitarget of the proto-oncogene tyrosine-protein kinase Src (SRC), tyrosine-protein kinase ABL1, tyrosine-protein kinase ABL2, and tyrosine-protein kinase Fyn (FYN), along with 19 other proteins.
Contaminant Sources
  • HMDB Contaminants - Urine
  • STOFF IDENT Compounds
  • ToxCast & Tox21 Chemicals
Contaminant TypeNot Available
Chemical Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms
ValueSource
Anh. dasatinibChEBI
Anhydrous dasatinibChEBI
BMS DasatinibChEBI
BMS-354825ChEBI
Dasatinib (anh.)ChEBI
DasatinibumChEBI
N-(2-CHLORO-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamideChEBI
(18F)-N-(2-Chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamideHMDB
N-(2-Chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamideHMDB
SprycelHMDB
Chemical FormulaC22H26ClN7O2S
Average Molecular Mass488.006 g/mol
Monoisotopic Mass487.156 g/mol
CAS Registry Number302962-49-8
IUPAC NameN-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide
Traditional Namedasatinib
SMILESCC1=NC(NC2=NC=C(S2)C(=O)NC2=C(C)C=CC=C2Cl)=CC(=N1)N1CCN(CCO)CC1
InChI IdentifierInChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
InChI KeyZBNZXTGUTAYRHI-UHFFFAOYSA-N
Chemical Taxonomy
Description belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentAlpha amino acid amides
Alternative Parents
Substituents
  • Alpha-amino acid amide
  • Amphetamine or derivatives
  • Phenylpropane
  • Monocyclic benzene moiety
  • Fatty amide
  • Fatty acyl
  • Benzenoid
  • N-acyl-amine
  • Carboxamide group
  • Secondary carboxylic acid amide
  • Organic nitrogen compound
  • Organooxygen compound
  • Organonitrogen compound
  • Primary amine
  • Primary aliphatic amine
  • Hydrocarbon derivative
  • Organic oxide
  • Carbonyl group
  • Organopnictogen compound
  • Organic oxygen compound
  • Amine
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External DescriptorsNot Available
Biological Properties
StatusDetected and Not Quantified
OriginNot Available
Cellular LocationsNot Available
Biofluid LocationsNot Available
Tissue LocationsNot Available
Pathways
NameSMPDB LinkKEGG Link
Dasatinib Inhibition of BCR-ABL Action PathwaySMP0031696 Not Available
Dasatinib Drug Metabolism Action PathwaySMP0143671 Not Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Physical Properties
StateNot Available
AppearanceNot Available
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.013 g/LALOGPS
logP2.77ALOGPS
logP3.82ChemAxon
logS-4.6ALOGPS
pKa (Strongest Acidic)8.49ChemAxon
pKa (Strongest Basic)7.22ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count8ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area106.51 ŲChemAxon
Rotatable Bond Count7ChemAxon
Refractivity133.08 m³·mol⁻¹ChemAxon
Polarizability51.58 ųChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyView
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positivesplash10-0a4j-3104900000-19c063b36c545a5eb85aSpectrum
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (1 TMS) - 70eV, Positivesplash10-00r7-3101490000-d274cb5f2cc0589526f6Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, PositiveNot AvailableSpectrum
LC-MS/MSLC-MS/MS Spectrum - , positivesplash10-000m-0390000000-8a413cb9e53d14cbe10aSpectrum
LC-MS/MSLC-MS/MS Spectrum - , positivesplash10-000i-0011900000-4dac51b915117532ebe0Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-000l-0521900000-f036db5f090dc721c061Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0006-0945000000-1344a7f6fa72fda9679cSpectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0006-1941000000-7dd50ec0e4437edbdddbSpectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-06ri-0293600000-003749b25fb59315664fSpectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-066v-1292100000-f90b69c609d80d3f92a8Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0a4i-3390000000-0e74e360d8dc98f4adc8Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-000i-0000900000-e70e9316e0f943fd209dSpectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-000i-0001900000-009c64fdb2ae58cfd0fbSpectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0f72-7395800000-2de6701f9f023ff4fc04Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-000i-0000900000-25ba0df4df3ee5cf8e03Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0fs9-4112900000-d8d24063d0379ec5b337Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-001i-4192000000-f29c2b38b827f08243f6Spectrum
Toxicity Profile
Route of ExposureNot Available
Mechanism of ToxicityNot Available
MetabolismNot Available
Toxicity ValuesNot Available
Lethal DoseNot Available
Carcinogenicity (IARC Classification)Not Available
Uses/SourcesNot Available
Minimum Risk LevelNot Available
Health EffectsNot Available
SymptomsNot Available
TreatmentNot Available
Concentrations
Not Available
DrugBank IDDB01254
HMDB IDHMDB0015384
FooDB IDNot Available
Phenol Explorer IDNot Available
KNApSAcK IDNot Available
BiGG IDNot Available
BioCyc IDNot Available
METLIN IDNot Available
PDB IDNot Available
Wikipedia LinkDasatinib
Chemspider ID2323020
ChEBI ID49375
PubChem Compound ID3062316
Kegg Compound IDNot Available
YMDB IDNot Available
ECMDB IDNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General References
1. Talpaz M, Shah NP, Kantarjian H, Donato N, Nicoll J, Paquette R, Cortes J, O'Brien S, Nicaise C, Bleickardt E, Blackwood-Chirchir MA, Iyer V, Chen TT, Huang F, Decillis AP, Sawyers CL: Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med. 2006 Jun 15;354(24):2531-41.
2. Das J, Chen P, Norris D, Padmanabha R, Lin J, Moquin RV, Shen Z, Cook LS, Doweyko AM, Pitt S, Pang S, Shen DR, Fang Q, de Fex HF, McIntyre KW, Shuster DJ, Gillooly KM, Behnia K, Schieven GL, Wityak J, Barrish JC: 2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor. J Med Chem. 2006 Nov 16;49(23):6819-32.
3. https://www.ncbi.nlm.nih.gov/pubmed/?term=16775234
4. https://www.ncbi.nlm.nih.gov/pubmed/?term=17154512
5. https://www.ncbi.nlm.nih.gov/pubmed/?term=18020922
6. https://www.ncbi.nlm.nih.gov/pubmed/?term=18784745
7. https://www.ncbi.nlm.nih.gov/pubmed/?term=18797457
8. https://www.ncbi.nlm.nih.gov/pubmed/?term=18823558
9. https://www.ncbi.nlm.nih.gov/pubmed/?term=19494352
10. https://www.ncbi.nlm.nih.gov/pubmed/?term=19502192
11. https://www.ncbi.nlm.nih.gov/pubmed/?term=19640584
12. https://www.ncbi.nlm.nih.gov/pubmed/?term=21226671
13. https://www.ncbi.nlm.nih.gov/pubmed/?term=22411867
14. https://www.ncbi.nlm.nih.gov/pubmed/?term=22740998
15. https://www.ncbi.nlm.nih.gov/pubmed/?term=22992064
16. https://www.ncbi.nlm.nih.gov/pubmed/?term=23065516