Record Information |
---|
Version | 1.0 |
---|
Creation Date | 2016-05-22 04:28:23 UTC |
---|
Update Date | 2016-11-09 01:15:37 UTC |
---|
Accession Number | CHEM017577 |
---|
Identification |
---|
Common Name | Megestrol acetate |
---|
Class | Small Molecule |
---|
Description | 17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer. |
---|
Contaminant Sources | - ToxCast & Tox21 Chemicals
|
---|
Contaminant Type | Not Available |
---|
Chemical Structure | |
---|
Synonyms | Value | Source |
---|
Megace | Kegg | Megestrol acetic acid | Generator | Mestrel | MeSH | Nu megestrol | MeSH | NuMegestrol | MeSH | apo Megestrol | MeSH | Lin megestrol | MeSH | Nu-megestrol | MeSH | Nu-pharm brand OF megestrol acetate | MeSH | LinMegestrol | MeSH | Prasfarma brand OF megestrol acetate | MeSH | apo-Megestrol | MeSH | ApoMegestrol | MeSH | Bristol-myers squibb brand OF megestrol acetate | MeSH | Maygace | MeSH | Borea | MeSH | Linson pharma brand OF megestrol acetate | MeSH | Megestat | MeSH | Megostat | MeSH | Apotex brand OF megestrol acetate | MeSH | Bristol-myers brand OF megestrol acetate | MeSH | Lin-megestrol | MeSH | Acetate, megestrol | MeSH | Bristol myers brand OF megestrol acetate | MeSH | Lemery brand OF megestrol acetate | MeSH | Nu pharm brand OF megestrol acetate | MeSH | Bristol myers squibb brand OF megestrol acetate | MeSH | Madaus brand OF megestrol acetate | MeSH | Megefren | MeSH | Squibb brand OF megestrol acetate | MeSH |
|
---|
Chemical Formula | C24H32O4 |
---|
Average Molecular Mass | 384.516 g/mol |
---|
Monoisotopic Mass | 384.230 g/mol |
---|
CAS Registry Number | 595-33-5 |
---|
IUPAC Name | (1S,2R,10R,11S,14R,15S)-14-acetyl-2,8,15-trimethyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-6,8-dien-14-yl acetate |
---|
Traditional Name | DMAP |
---|
SMILES | [H][C@@]12CC[C@](OC(C)=O)(C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])C=C(C)C2=CC(=O)CC[C@]12C |
---|
InChI Identifier | InChI=1S/C24H32O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h12-13,18-20H,6-11H2,1-5H3/t18-,19+,20+,22-,23+,24+/m1/s1 |
---|
InChI Key | RQZAXGRLVPAYTJ-GQFGMJRRSA-N |
---|
Chemical Taxonomy |
---|
Description | belongs to the class of organic compounds known as gluco/mineralocorticoids, progestogins and derivatives. These are steroids with a structure based on a hydroxylated prostane moiety. |
---|
Kingdom | Organic compounds |
---|
Super Class | Lipids and lipid-like molecules |
---|
Class | Steroids and steroid derivatives |
---|
Sub Class | Pregnane steroids |
---|
Direct Parent | Gluco/mineralocorticoids, progestogins and derivatives |
---|
Alternative Parents | |
---|
Substituents | - Progestogin-skeleton
- 20-oxosteroid
- Steroid ester
- 3-oxosteroid
- Oxosteroid
- Cyclohexenone
- Alpha-acyloxy ketone
- Ketone
- Carboxylic acid ester
- Cyclic ketone
- Monocarboxylic acid or derivatives
- Carboxylic acid derivative
- Hydrocarbon derivative
- Organic oxygen compound
- Organooxygen compound
- Organic oxide
- Carbonyl group
- Aliphatic homopolycyclic compound
|
---|
Molecular Framework | Aliphatic homopolycyclic compounds |
---|
External Descriptors | - C21 steroids (gluco/mineralocorticoids, progestogens) and derivatives (C08151 )
- C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives (LMST02030118 )
|
---|
Biological Properties |
---|
Status | Detected and Not Quantified |
---|
Origin | Not Available |
---|
Cellular Locations | Not Available |
---|
Biofluid Locations | Not Available |
---|
Tissue Locations | Not Available |
---|
Pathways | Not Available |
---|
Applications | Not Available |
---|
Biological Roles | Not Available |
---|
Chemical Roles | Not Available |
---|
Physical Properties |
---|
State | Not Available |
---|
Appearance | Not Available |
---|
Experimental Properties | Property | Value |
---|
Melting Point | Not Available | Boiling Point | Not Available | Solubility | Not Available |
|
---|
Predicted Properties | |
---|
Spectra |
---|
Spectra | Spectrum Type | Description | Splash Key | View |
---|
LC-MS/MS | LC-MS/MS Spectrum - , positive | splash10-002r-0379000000-6d73cd082b939b89d5ce | Spectrum | LC-MS/MS | LC-MS/MS Spectrum - , positive | splash10-060r-2890000000-fa2ec02a8c51a731cc7b | Spectrum | LC-MS/MS | LC-MS/MS Spectrum - LC-ESI-QFT , positive | splash10-00n0-0497000000-046272fbcad7d1d41298 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-000l-0009000000-59a0980387ea4612f8f5 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-00mo-0059000000-5a746fc4d3061ff006bf | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0v4i-1981000000-0886e38a4167a0cb7c1e | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-001l-1009000000-3ddafe06b118017c8af5 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-000x-2029000000-ae6024f2a71c21be2d49 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-0a6v-9067000000-723980bd7c6c229868b9 | Spectrum |
|
---|
Toxicity Profile |
---|
Route of Exposure | Not Available |
---|
Mechanism of Toxicity | Not Available |
---|
Metabolism | Not Available |
---|
Toxicity Values | Not Available |
---|
Lethal Dose | Not Available |
---|
Carcinogenicity (IARC Classification) | Not Available |
---|
Uses/Sources | Not Available |
---|
Minimum Risk Level | Not Available |
---|
Health Effects | Not Available |
---|
Symptoms | Not Available |
---|
Treatment | Not Available |
---|
Concentrations |
---|
| Not Available |
---|
External Links |
---|
DrugBank ID | DB00351 |
---|
HMDB ID | Not Available |
---|
FooDB ID | Not Available |
---|
Phenol Explorer ID | Not Available |
---|
KNApSAcK ID | Not Available |
---|
BiGG ID | Not Available |
---|
BioCyc ID | Not Available |
---|
METLIN ID | Not Available |
---|
PDB ID | Not Available |
---|
Wikipedia Link | Megestrol acetate |
---|
Chemspider ID | Not Available |
---|
ChEBI ID | Not Available |
---|
PubChem Compound ID | 11683 |
---|
Kegg Compound ID | C08151 |
---|
YMDB ID | Not Available |
---|
ECMDB ID | Not Available |
---|
References |
---|
Synthesis Reference | Not Available |
---|
MSDS | Not Available |
---|
General References | Not Available |
---|