Record Information |
---|
Version | 1.0 |
---|
Creation Date | 2016-05-22 04:26:07 UTC |
---|
Update Date | 2016-11-09 01:15:36 UTC |
---|
Accession Number | CHEM017527 |
---|
Identification |
---|
Common Name | Yohimbine |
---|
Class | Small Molecule |
---|
Description | A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac. |
---|
Contaminant Sources | - HMDB Contaminants - Urine
- STOFF IDENT Compounds
- ToxCast & Tox21 Chemicals
|
---|
Contaminant Type | Not Available |
---|
Chemical Structure | |
---|
Synonyms | Value | Source |
---|
(+)-Yohimbine | ChEBI | (16alpha,17alpha)-17-Hydroxyyohimban-16-carboxylic acid methyl ester | ChEBI | 17alpha-Hydroxyyohimban-16alpha-carboxylic acid methyl ester | ChEBI | Aphrodine | ChEBI | Corynine | ChEBI | Johimbin | ChEBI | Quebrachin | ChEBI | Quebrachine | ChEBI | Yohimbic acid methyl ester | ChEBI | Yohimbin | ChEBI | (16a,17a)-17-Hydroxyyohimban-16-carboxylate methyl ester | Generator | (16a,17a)-17-Hydroxyyohimban-16-carboxylic acid methyl ester | Generator | (16alpha,17alpha)-17-Hydroxyyohimban-16-carboxylate methyl ester | Generator | (16Α,17α)-17-hydroxyyohimban-16-carboxylate methyl ester | Generator | (16Α,17α)-17-hydroxyyohimban-16-carboxylic acid methyl ester | Generator | 17a-Hydroxyyohimban-16a-carboxylate methyl ester | Generator | 17a-Hydroxyyohimban-16a-carboxylic acid methyl ester | Generator | 17alpha-Hydroxyyohimban-16alpha-carboxylate methyl ester | Generator | 17Α-hydroxyyohimban-16α-carboxylate methyl ester | Generator | 17Α-hydroxyyohimban-16α-carboxylic acid methyl ester | Generator | Yohimbate methyl ester | Generator | Aphrodyne | HMDB | Aventis brand OF yohimbine hydrochloride | HMDB | Solvay brand OF yohimbine hydrochloride | HMDB | Yohimbine hydrochloride | HMDB | Aphrodine hydrochloride | HMDB | Hydrochloride, yohimbine | HMDB | Pluriviron | HMDB | Rauwolscine | HMDB | Palisades brand OF yohimbine hydrochloride | HMDB | Star brand OF yohimbine hydrochloride | HMDB | StegroPharm brand OF yohimbine hydrochloride | HMDB | Tartrate, corynanthine | HMDB | Corynanthine | HMDB | Corynanthine tartrate | HMDB | Glenwood brand OF yohimbine hydrochloride | HMDB | Hydrochloride, aphrodine | HMDB | Kramer brand OF yohimbine hydrochloride | HMDB | Rauhimbine | HMDB | Yocon | HMDB | Yohimbin spiegel | HMDB | Yohimbine houdé | HMDB | Yohimex | HMDB |
|
---|
Chemical Formula | C21H26N2O3 |
---|
Average Molecular Mass | 354.443 g/mol |
---|
Monoisotopic Mass | 354.194 g/mol |
---|
CAS Registry Number | 146-48-5 |
---|
IUPAC Name | methyl (1S,15R,18S,19R,20S)-18-hydroxy-3,13-diazapentacyclo[11.8.0.0²,¹⁰.0⁴,⁹.0¹⁵,²⁰]henicosa-2(10),4,6,8-tetraene-19-carboxylate |
---|
Traditional Name | yohimbine |
---|
SMILES | [H][C@@]12CC[C@H](O)[C@H](C(=O)OC)[C@@]1([H])C[C@]1([H])N(CCC3=C1NC1=CC=CC=C31)C2 |
---|
InChI Identifier | InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1 |
---|
InChI Key | BLGXFZZNTVWLAY-SCYLSFHTSA-N |
---|
Chemical Taxonomy |
---|
Description | belongs to the class of organic compounds known as yohimbine alkaloids. These are alkaloids containing the pentacyclic yohimban skeleton. The Yohimbinoid alkaloids contain a carbocyclic ring E arising through C-17 to C-18 bond formation in a corynantheine precursor. |
---|
Kingdom | Organic compounds |
---|
Super Class | Alkaloids and derivatives |
---|
Class | Yohimbine alkaloids |
---|
Sub Class | Not Available |
---|
Direct Parent | Yohimbine alkaloids |
---|
Alternative Parents | |
---|
Substituents | - Yohimbine
- Corynanthean skeleton
- Yohimbine alkaloid
- Beta-carboline
- Pyridoindole
- 3-alkylindole
- Indole
- Indole or derivatives
- Aralkylamine
- Beta-hydroxy acid
- Hydroxy acid
- Benzenoid
- Piperidine
- Heteroaromatic compound
- Methyl ester
- Cyclic alcohol
- Pyrrole
- Amino acid or derivatives
- Tertiary aliphatic amine
- Carboxylic acid ester
- Tertiary amine
- Secondary alcohol
- Azacycle
- Monocarboxylic acid or derivatives
- Carboxylic acid derivative
- Organoheterocyclic compound
- Organic oxide
- Organonitrogen compound
- Organic nitrogen compound
- Organooxygen compound
- Amine
- Carbonyl group
- Organic oxygen compound
- Alcohol
- Organopnictogen compound
- Hydrocarbon derivative
- Aromatic heteropolycyclic compound
|
---|
Molecular Framework | Aromatic heteropolycyclic compounds |
---|
External Descriptors | - methyl 17-hydroxy-20xi-yohimban-16-carboxylate (CHEBI:10093 )
- Indole alkaloids (C09256 )
|
---|
Biological Properties |
---|
Status | Detected and Not Quantified |
---|
Origin | Not Available |
---|
Cellular Locations | Not Available |
---|
Biofluid Locations | Not Available |
---|
Tissue Locations | Not Available |
---|
Pathways | Not Available |
---|
Applications | Not Available |
---|
Biological Roles | Not Available |
---|
Chemical Roles | Not Available |
---|
Physical Properties |
---|
State | Not Available |
---|
Appearance | Not Available |
---|
Experimental Properties | Property | Value |
---|
Melting Point | Not Available | Boiling Point | Not Available | Solubility | Not Available |
|
---|
Predicted Properties | |
---|
Spectra |
---|
Spectra | Spectrum Type | Description | Splash Key | View |
---|
Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | splash10-008i-0396000000-43448cca1e1ad4343ac0 | Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (1 TMS) - 70eV, Positive | splash10-00xs-2139200000-8288a21cfcdae82fc694 | Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | Not Available | Spectrum | LC-MS/MS | LC-MS/MS Spectrum - , positive | splash10-0006-3921000000-e28dd8692e2b8dd63330 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-0a4r-0019000000-98fd50566f845231fbed | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-0a4r-0129000000-49a3b77851cb2f327e51 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0ffx-0891000000-1297a98bf2d980f32361 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-0udi-0009000000-6448f2e7be3b7fa35128 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-0udi-0009000000-a436855e9ddc5d8e061e | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-07ef-3956000000-386e3fa9fb16f1a30cf6 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-0a4i-0009000000-b3d998cb3c47c9700660 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-0a4i-0009000000-42b2cee0514145bdbc16 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-002g-0695000000-7eacdb4b3fbff0521dcd | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-0udi-0009000000-1bc1d16b561be98b6dbc | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-004i-0095000000-d9723526ae361fda41c5 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-0f96-0192000000-a13fb9eefdc725558673 | Spectrum |
|
---|
Toxicity Profile |
---|
Route of Exposure | Not Available |
---|
Mechanism of Toxicity | Not Available |
---|
Metabolism | Not Available |
---|
Toxicity Values | Not Available |
---|
Lethal Dose | Not Available |
---|
Carcinogenicity (IARC Classification) | Not Available |
---|
Uses/Sources | Not Available |
---|
Minimum Risk Level | Not Available |
---|
Health Effects | Not Available |
---|
Symptoms | Not Available |
---|
Treatment | Not Available |
---|
Concentrations |
---|
| Not Available |
---|
External Links |
---|
DrugBank ID | DB01392 |
---|
HMDB ID | HMDB0015464 |
---|
FooDB ID | Not Available |
---|
Phenol Explorer ID | Not Available |
---|
KNApSAcK ID | C00001789 |
---|
BiGG ID | Not Available |
---|
BioCyc ID | Not Available |
---|
METLIN ID | Not Available |
---|
PDB ID | Not Available |
---|
Wikipedia Link | Yohimbine |
---|
Chemspider ID | 8622 |
---|
ChEBI ID | 10093 |
---|
PubChem Compound ID | 8969 |
---|
Kegg Compound ID | C09256 |
---|
YMDB ID | Not Available |
---|
ECMDB ID | Not Available |
---|
References |
---|
Synthesis Reference | Not Available |
---|
MSDS | Not Available |
---|
General References | Not Available |
---|