Record Information |
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Version | 1.0 |
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Creation Date | 2016-05-22 04:14:11 UTC |
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Update Date | 2016-11-09 01:15:34 UTC |
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Accession Number | CHEM017312 |
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Identification |
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Common Name | Adriamycin hydrochloride |
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Class | Small Molecule |
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Description | Not Available |
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Contaminant Sources | - ToxCast & Tox21 Chemicals
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Contaminant Type | Not Available |
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Chemical Structure | |
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Synonyms | Value | Source |
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Adriacin | Kegg | Adriamycin | Kegg | Doxil | Kegg | Rubex | Kegg | Adriablastin | MeSH | Adriablastine | MeSH | Baxter brand OF doxorubicin hydrochloride | MeSH | Bristol-myers squibb brand OF doxorubicin hydrochloride | MeSH | Ferrer brand OF doxorubicin hydrochloride | MeSH | Hydrochloride, doxorubicin | MeSH | Adriblastina | MeSH | Doxorubicin | MeSH | Doxorubicin NC | MeSH | Doxorubicina ferrer farm | MeSH | Doxorubicina funk | MeSH | Doxotec | MeSH | Kenfarma brand OF doxorubicin hydrochloride | MeSH | Myocet | MeSH | Doxorubicina tedec | MeSH | Hexal brand OF doxorubicin hydrochloride | MeSH | Doxolem | MeSH | Neocorp brand OF doxorubicin hydrochloride | MeSH | Pfizer brand OF doxorubicin hydrochloride | MeSH | Urokit doxo-cell | MeSH | Medac brand OF doxorubicin hydrochloride | MeSH | Ribosepharm brand OF doxorubicin hydrochloride | MeSH | Adriblastin | MeSH | Doxorubicine baxter | MeSH | Onkoworks brand OF doxorubicin hydrochloride | MeSH | Urokit doxo cell | MeSH | Adrimedac | MeSH | Bedford brand OF doxorubicin hydrochloride | MeSH | doxo Cell | MeSH | Elan brand OF doxorubicin hydrochloride | MeSH | Prasfarma brand OF doxorubicin hydrochloride | MeSH | Lemery brand OF doxorubicin hydrochloride | MeSH | Onkodox | MeSH | Ribodoxo | MeSH | Tedec meiji brand OF doxorubicin hydrochloride | MeSH | Adriblastine | MeSH | Columbia brand OF doxorubicin hydrochloride | MeSH | doxo-Cell | MeSH | Doxorubicin hexal | MeSH | Farmiblastina | MeSH | Cell pharm brand OF doxorubicin hydrochloride | MeSH |
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Chemical Formula | C27H30ClNO11 |
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Average Molecular Mass | 579.980 g/mol |
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Monoisotopic Mass | 579.151 g/mol |
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CAS Registry Number | 25316-40-9 |
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IUPAC Name | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione hydrochloride |
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Traditional Name | doxorubicin hydrochloride |
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SMILES | Cl.[H][C@]1(N)C[C@]([H])(O[C@@]2([H])C[C@@](O)(CC3=C(O)C4=C(C(O)=C23)C(=O)C2=C(C=CC=C2OC)C4=O)C(=O)CO)O[C@@]([H])(C)[C@@]1([H])O |
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InChI Identifier | InChI=1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1 |
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InChI Key | MWWSFMDVAYGXBV-RUELKSSGSA-N |
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Chemical Taxonomy |
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Description | belongs to the class of organic compounds known as anthracyclines. These are polyketides containing a tetracenequinone ring structure with a sugar attached by glycosidic linkage. |
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Kingdom | Organic compounds |
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Super Class | Phenylpropanoids and polyketides |
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Class | Anthracyclines |
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Sub Class | Not Available |
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Direct Parent | Anthracyclines |
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Alternative Parents | |
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Substituents | - Anthracycline
- Anthracyclinone-skeleton
- Aminoglycoside core
- Tetracenequinone
- 9,10-anthraquinone
- 1,4-anthraquinone
- Anthracene
- Hexose monosaccharide
- Glycosyl compound
- O-glycosyl compound
- Tetralin
- Anisole
- Aryl ketone
- Alkyl aryl ether
- Amino saccharide
- Benzenoid
- Monosaccharide
- Oxane
- Alpha-hydroxy ketone
- Tertiary alcohol
- Vinylogous acid
- Secondary alcohol
- Ketone
- 1,2-aminoalcohol
- Polyol
- Oxacycle
- Acetal
- Organoheterocyclic compound
- Ether
- Alcohol
- Carbonyl group
- Primary aliphatic amine
- Hydrochloride
- Organonitrogen compound
- Hydrocarbon derivative
- Organic oxide
- Organopnictogen compound
- Organic oxygen compound
- Amine
- Organooxygen compound
- Organic nitrogen compound
- Primary alcohol
- Primary amine
- Aromatic heteropolycyclic compound
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Molecular Framework | Aromatic heteropolycyclic compounds |
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External Descriptors | Not Available |
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Biological Properties |
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Status | Detected and Not Quantified |
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Origin | Not Available |
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Cellular Locations | Not Available |
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Biofluid Locations | Not Available |
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Tissue Locations | Not Available |
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Pathways | Not Available |
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Applications | Not Available |
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Biological Roles | Not Available |
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Chemical Roles | Not Available |
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Physical Properties |
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State | Not Available |
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Appearance | Not Available |
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Experimental Properties | Property | Value |
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Melting Point | Not Available | Boiling Point | Not Available | Solubility | Not Available |
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Predicted Properties | |
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Spectra |
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Spectra | Spectrum Type | Description | Splash Key | View |
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Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-001i-0000090000-deac82977e6ad326c74a | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-001i-0000090000-deac82977e6ad326c74a | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-001i-0000090000-deac82977e6ad326c74a | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-004i-0000090000-d14c313940169cb76d20 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-004i-0000090000-d14c313940169cb76d20 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-004i-0000090000-d14c313940169cb76d20 | Spectrum |
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Toxicity Profile |
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Route of Exposure | Not Available |
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Mechanism of Toxicity | Not Available |
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Metabolism | Not Available |
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Toxicity Values | Not Available |
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Lethal Dose | Not Available |
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Carcinogenicity (IARC Classification) | Not Available |
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Uses/Sources | Not Available |
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Minimum Risk Level | Not Available |
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Health Effects | Not Available |
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Symptoms | Not Available |
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Treatment | Not Available |
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Concentrations |
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| Not Available |
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External Links |
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DrugBank ID | Not Available |
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HMDB ID | Not Available |
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FooDB ID | Not Available |
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Phenol Explorer ID | Not Available |
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KNApSAcK ID | Not Available |
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BiGG ID | Not Available |
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BioCyc ID | Not Available |
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METLIN ID | Not Available |
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PDB ID | Not Available |
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Wikipedia Link | Not Available |
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Chemspider ID | Not Available |
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ChEBI ID | Not Available |
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PubChem Compound ID | 443939 |
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Kegg Compound ID | Not Available |
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YMDB ID | Not Available |
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ECMDB ID | Not Available |
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References |
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Synthesis Reference | Not Available |
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MSDS | Not Available |
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General References | Not Available |
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