Record Information |
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Version | 1.0 |
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Creation Date | 2016-05-22 03:44:47 UTC |
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Update Date | 2016-11-09 01:15:28 UTC |
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Accession Number | CHEM016825 |
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Identification |
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Common Name | Pemoline |
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Class | Small Molecule |
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Description | A member of the class of 1,3-oxazoles that is 1,3-oxazol-4(5H)-one which is substituted by an amino group at position 2 and by a phenyl group at position 5. A central nervous system stimulant, it was used to treat hyperactivity disorders in children, but withdrawn from use following reports of serious hepatotoxicity. |
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Contaminant Sources | - STOFF IDENT Compounds
- ToxCast & Tox21 Chemicals
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Contaminant Type | Not Available |
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Chemical Structure | |
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Synonyms | Value | Source |
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2-Amino-5-phenyl-4(5H)-oxazolone | ChEBI | 2-Imino-4-keto-5-phenyltetrahydrooxazole | ChEBI | 2-Imino-5-phenyl-4-oxazolidinone | ChEBI | 5-Phenyl-2-imino-4-oxazolidinone | ChEBI | 5-Phenyl-2-imino-4-oxooxazolidine | ChEBI | 5-Phenylisohydantion | ChEBI | Azoxodon | ChEBI | Betanamin | ChEBI | Cylert | ChEBI | Dantromin | ChEBI | Deltamine | ChEBI | Hyton | ChEBI | Myamin | ChEBI | Nitan | ChEBI | Notair | ChEBI | Pemolina | ChEBI | Pemolinum | ChEBI | Pheniminooxazolidinone | ChEBI | Phenylisohydantoin | ChEBI | Phenylpseudohydantoin | ChEBI | Abbott brand OF pemoline | MeSH | Lilly brand OF pemoline | MeSH | Compounds, pemoline | MeSH | Pemoline compounds | MeSH | Tradon | MeSH | Magnesium, pemoline | MeSH | Mallinckrodt brand OF pemoline | MeSH | PemADD | MeSH | Pemoline magnesium | MeSH | Phenoxazole | MeSH |
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Chemical Formula | C9H8N2O2 |
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Average Molecular Mass | 176.172 g/mol |
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Monoisotopic Mass | 176.059 g/mol |
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CAS Registry Number | 2152-34-3 |
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IUPAC Name | 2-amino-5-phenyl-4,5-dihydro-1,3-oxazol-4-one |
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Traditional Name | pemoline |
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SMILES | NC1=NC(=O)C(O1)C1=CC=CC=C1 |
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InChI Identifier | InChI=1S/C9H8N2O2/c10-9-11-8(12)7(13-9)6-4-2-1-3-5-6/h1-5,7H,(H2,10,11,12) |
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InChI Key | NRNCYVBFPDDJNE-UHFFFAOYSA-N |
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Chemical Taxonomy |
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Description | belongs to the class of organic compounds known as benzene and substituted derivatives. These are aromatic compounds containing one monocyclic ring system consisting of benzene. |
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Kingdom | Organic compounds |
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Super Class | Benzenoids |
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Class | Benzene and substituted derivatives |
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Sub Class | Not Available |
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Direct Parent | Benzene and substituted derivatives |
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Alternative Parents | |
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Substituents | - Monocyclic benzene moiety
- Oxazoline
- Oxacycle
- Azacycle
- Organoheterocyclic compound
- Organic 1,3-dipolar compound
- Propargyl-type 1,3-dipolar organic compound
- Organic nitrogen compound
- Organic oxygen compound
- Organopnictogen compound
- Hydrocarbon derivative
- Organooxygen compound
- Organonitrogen compound
- Imine
- Aromatic heteromonocyclic compound
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Molecular Framework | Aromatic heteromonocyclic compounds |
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External Descriptors | |
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Biological Properties |
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Status | Detected and Not Quantified |
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Origin | Not Available |
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Cellular Locations | Not Available |
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Biofluid Locations | Not Available |
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Tissue Locations | Not Available |
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Pathways | Not Available |
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Applications | Not Available |
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Biological Roles | Not Available |
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Chemical Roles | Not Available |
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Physical Properties |
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State | Not Available |
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Appearance | Not Available |
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Experimental Properties | Property | Value |
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Melting Point | Not Available | Boiling Point | Not Available | Solubility | Not Available |
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Predicted Properties | |
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Spectra |
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Spectra | Spectrum Type | Description | Splash Key | View |
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Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | splash10-052f-7900000000-ff16f04882fa6bc388b4 | Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | Not Available | Spectrum | LC-MS/MS | LC-MS/MS Spectrum - LC-ESI-qTof , Positive | splash10-0a4i-1900000000-6304707e673e5496a706 | Spectrum | LC-MS/MS | LC-MS/MS Spectrum - , positive | splash10-0a4i-1900000000-6304707e673e5496a706 | Spectrum | LC-MS/MS | LC-MS/MS Spectrum - 35V, Negative | splash10-0006-9000000000-6312df1dd9b3c1da44a0 | Spectrum | LC-MS/MS | LC-MS/MS Spectrum - 35V, Positive | splash10-0a4i-3900000000-355d61158f2b03978708 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-004i-0900000000-5fdd1bf70ae74ce0100a | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-05r3-1900000000-9afcde2920ef21e932f6 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0aou-9700000000-37842f170bf0d611bc61 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-004i-1900000000-a834fbdc5b9e8c4b0eb3 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-004i-9700000000-770e8d3a8e42b5bad6c4 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-0006-9100000000-6ded2f5c4a0ee37a0e13 | Spectrum |
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Toxicity Profile |
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Route of Exposure | Not Available |
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Mechanism of Toxicity | Not Available |
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Metabolism | Not Available |
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Toxicity Values | Not Available |
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Lethal Dose | Not Available |
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Carcinogenicity (IARC Classification) | Not Available |
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Uses/Sources | Not Available |
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Minimum Risk Level | Not Available |
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Health Effects | Not Available |
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Symptoms | Not Available |
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Treatment | Not Available |
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Concentrations |
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| Not Available |
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External Links |
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DrugBank ID | DB01230 |
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HMDB ID | HMDB0256214 |
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FooDB ID | Not Available |
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Phenol Explorer ID | Not Available |
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KNApSAcK ID | Not Available |
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BiGG ID | Not Available |
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BioCyc ID | Not Available |
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METLIN ID | Not Available |
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PDB ID | Not Available |
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Wikipedia Link | Pemoline |
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Chemspider ID | 4561 |
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ChEBI ID | 7953 |
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PubChem Compound ID | Not Available |
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Kegg Compound ID | C07899 |
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YMDB ID | Not Available |
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ECMDB ID | Not Available |
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References |
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Synthesis Reference | Not Available |
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MSDS | Not Available |
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General References | |
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