Record Information |
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Version | 1.0 |
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Creation Date | 2016-05-22 03:43:42 UTC |
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Update Date | 2016-11-09 01:15:28 UTC |
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Accession Number | CHEM016788 |
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Identification |
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Common Name | Metyrosine |
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Class | Small Molecule |
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Description | An L-tyrosine derivative that consists of L-tyrosine bearing an additional methyl substituent at position 2. An inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma. |
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Contaminant Sources | - HMDB Contaminants - Urine
- STOFF IDENT Compounds
- ToxCast & Tox21 Chemicals
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Contaminant Type | Not Available |
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Chemical Structure | |
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Synonyms | Value | Source |
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(-)-alpha-Methyl-L-tyrosine | ChEBI | (S)-alpha-Methyltyrosine | ChEBI | alpha-Methyl-L-p-tyrosine | ChEBI | alpha-Methyl-p-tyrosine | ChEBI | alpha-Methyl-para-tyrosine | ChEBI | alpha-Methyltyrosine | ChEBI | L-alpha-Methyltyrosine | ChEBI | Methyltyrosine | ChEBI | Metirosina | ChEBI | Metirosine | ChEBI | Metirosinum | ChEBI | Demser | Kegg | (-)-a-Methyl-L-tyrosine | Generator | (-)-Α-methyl-L-tyrosine | Generator | (S)-a-Methyltyrosine | Generator | (S)-Α-methyltyrosine | Generator | a-Methyl-L-p-tyrosine | Generator | Α-methyl-L-p-tyrosine | Generator | a-Methyl-p-tyrosine | Generator | Α-methyl-p-tyrosine | Generator | a-Methyl-para-tyrosine | Generator | Α-methyl-para-tyrosine | Generator | a-Methyltyrosine | Generator | Α-methyltyrosine | Generator | L-a-Methyltyrosine | Generator | L-Α-methyltyrosine | Generator | alpha Methyltyrosine hydrochloride | HMDB | alpha-Methyltyrosine, (+,-)-isomer | HMDB | alpha MPT | HMDB | alpha Methyl para tyrosine | HMDB | alpha-MPT | HMDB | alpha-Methyltyrosine, (D,L)-isomer | HMDB | alpha-Methyltyrosine, (L)-isomer | HMDB | Hydrochloride, alpha-methyltyrosine | HMDB | Metyrosine merck brand | HMDB | Racemetirosine | HMDB | alpha Methyl p tyrosine | HMDB | Merck brand OF metyrosine | HMDB | Merck sharp and dohme brand OF metyrosine | HMDB | alpha Methyltyrosine | HMDB | alpha-Methyltyrosine hydrochloride | HMDB | alpha-Methyl- DL-tyrosine | HMDB | a-Methyl-L-tyrosine | HMDB | Α-methyl-L-tyrosine | HMDB | Metyrosine | ChEBI |
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Chemical Formula | C10H13NO3 |
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Average Molecular Mass | 195.215 g/mol |
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Monoisotopic Mass | 195.090 g/mol |
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CAS Registry Number | 672-87-7 |
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IUPAC Name | (2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid |
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Traditional Name | metyrosine |
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SMILES | C[C@](N)(CC1=CC=C(O)C=C1)C(O)=O |
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InChI Identifier | InChI=1S/C10H13NO3/c1-10(11,9(13)14)6-7-2-4-8(12)5-3-7/h2-5,12H,6,11H2,1H3,(H,13,14)/t10-/m0/s1 |
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InChI Key | NHTGHBARYWONDQ-JTQLQIEISA-N |
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Chemical Taxonomy |
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Description | belongs to the class of organic compounds known as phenylpropanoic acids. Phenylpropanoic acids are compounds with a structure containing a benzene ring conjugated to a propanoic acid. |
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Kingdom | Organic compounds |
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Super Class | Phenylpropanoids and polyketides |
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Class | Phenylpropanoic acids |
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Sub Class | Not Available |
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Direct Parent | Phenylpropanoic acids |
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Alternative Parents | |
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Substituents | - 3-phenylpropanoic-acid
- Alpha-amino acid
- Alpha-amino acid or derivatives
- Amphetamine or derivatives
- D-alpha-amino acid
- Phenylpropane
- 1-hydroxy-2-unsubstituted benzenoid
- Aralkylamine
- Phenol
- Monocyclic benzene moiety
- Benzenoid
- Amino acid or derivatives
- Amino acid
- Carboxylic acid derivative
- Carboxylic acid
- Monocarboxylic acid or derivatives
- Organic nitrogen compound
- Organonitrogen compound
- Primary aliphatic amine
- Organooxygen compound
- Primary amine
- Carbonyl group
- Hydrocarbon derivative
- Organic oxide
- Organopnictogen compound
- Amine
- Organic oxygen compound
- Aromatic homomonocyclic compound
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Molecular Framework | Aromatic homomonocyclic compounds |
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External Descriptors | |
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Biological Properties |
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Status | Detected and Not Quantified |
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Origin | Not Available |
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Cellular Locations | Not Available |
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Biofluid Locations | Not Available |
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Tissue Locations | Not Available |
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Pathways | Not Available |
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Applications | Not Available |
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Biological Roles | Not Available |
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Chemical Roles | Not Available |
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Physical Properties |
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State | Not Available |
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Appearance | Not Available |
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Experimental Properties | Property | Value |
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Melting Point | Not Available | Boiling Point | Not Available | Solubility | Not Available |
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Predicted Properties | |
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Spectra |
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Spectra | Spectrum Type | Description | Splash Key | View |
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Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | splash10-052f-4900000000-946ec0a9cb27d9dde874 | Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (2 TMS) - 70eV, Positive | splash10-00fu-9651000000-11b1bed7129ec3e5c27a | Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | Not Available | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-0udi-0900000000-7b2e7907b466193628f3 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-0udi-0900000000-8ee69272ff1683e7b679 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0a6r-3900000000-95f4506f225bff0a13e3 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-0006-3900000000-9aec0e31d6c52c6d4218 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-000i-9500000000-ea5a5dcd5c96018a361e | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-0kac-7900000000-25650809bb77fee5eb83 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-0ug1-0900000000-01322d7fad379ffae336 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-053r-0900000000-0f9c6bd0ffbe22e32c94 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-004i-9200000000-30cb5b9f46a657686267 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-0f6x-1900000000-3caf5c634bee6695a462 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-001i-3900000000-a9dda666c5606b501480 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-0536-7900000000-2d7f96942196ae0b76e0 | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum | 1D NMR | 13C NMR Spectrum | Not Available | Spectrum | 1D NMR | 1H NMR Spectrum | Not Available | Spectrum |
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Toxicity Profile |
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Route of Exposure | Not Available |
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Mechanism of Toxicity | Not Available |
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Metabolism | Not Available |
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Toxicity Values | Not Available |
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Lethal Dose | Not Available |
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Carcinogenicity (IARC Classification) | Not Available |
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Uses/Sources | Not Available |
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Minimum Risk Level | Not Available |
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Health Effects | Not Available |
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Symptoms | Not Available |
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Treatment | Not Available |
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Concentrations |
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| Not Available |
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External Links |
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DrugBank ID | DB00765 |
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HMDB ID | HMDB0014903 |
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FooDB ID | Not Available |
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Phenol Explorer ID | Not Available |
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KNApSAcK ID | Not Available |
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BiGG ID | Not Available |
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BioCyc ID | Not Available |
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METLIN ID | Not Available |
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PDB ID | Not Available |
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Wikipedia Link | Metirosine |
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Chemspider ID | 390103 |
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ChEBI ID | 6912 |
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PubChem Compound ID | 441350 |
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Kegg Compound ID | C07921 |
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YMDB ID | Not Available |
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ECMDB ID | Not Available |
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References |
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Synthesis Reference | Not Available |
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MSDS | Not Available |
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General References | |
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