Record Information |
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Version | 1.0 |
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Creation Date | 2016-05-22 03:41:25 UTC |
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Update Date | 2016-11-09 01:15:27 UTC |
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Accession Number | CHEM016721 |
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Identification |
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Common Name | Gliquidone |
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Class | Small Molecule |
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Description | Gliquidone is a sulfonylurea drug used to treat diabetes mellitus type 2. It is an ATP-dependent K+ (KATP) channel blocker. This block causes a depolarization which leads to activation of voltage-dependent Ca channels and Ca2+ influx, and eventually increases insulin release. |
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Contaminant Sources | - HMDB Contaminants - Urine
- STOFF IDENT Compounds
- ToxCast & Tox21 Chemicals
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Contaminant Type | Not Available |
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Chemical Structure | |
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Synonyms | Value | Source |
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Glurenorm | Kegg | Sanofi synthelabo brand OF gliquidone | HMDB | Glikvidon | HMDB | Gliquidone, monosodium salt | HMDB | AR-DF 26 | HMDB | Beglynora | HMDB | Yamanouchi brand OF gliquidone | HMDB | Beglynor | HMDB | Glurenor | HMDB | Gliquidone, calcium salt | HMDB | Glycvidon | HMDB | N'-cyclohexyl-N-{4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]benzenesulfonyl}carbamimidate | HMDB | N'-cyclohexyl-N-{4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]benzenesulphonyl}carbamimidate | HMDB | N'-cyclohexyl-N-{4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]benzenesulphonyl}carbamimidic acid | HMDB |
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Chemical Formula | C27H33N3O6S |
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Average Molecular Mass | 527.632 g/mol |
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Monoisotopic Mass | 527.209 g/mol |
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CAS Registry Number | 33342-05-1 |
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IUPAC Name | 1-cyclohexyl-3-{4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]benzenesulfonyl}urea |
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Traditional Name | gliquidone |
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SMILES | COC1=CC2=C(C=C1)C(C)(C)C(=O)N(CCC1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC1)C2=O |
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InChI Identifier | InChI=1S/C27H33N3O6S/c1-27(2)23-14-11-20(36-3)17-22(23)24(31)30(25(27)32)16-15-18-9-12-21(13-10-18)37(34,35)29-26(33)28-19-7-5-4-6-8-19/h9-14,17,19H,4-8,15-16H2,1-3H3,(H2,28,29,33) |
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InChI Key | LLJFMFZYVVLQKT-UHFFFAOYSA-N |
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Chemical Taxonomy |
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Description | belongs to the class of organic compounds known as 1,3-isoquinolinediones. These are isoquinoline derivatives carrying one C=O group at positions 1, and 3 respectively. |
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Kingdom | Organic compounds |
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Super Class | Organoheterocyclic compounds |
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Class | Isoquinolines and derivatives |
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Sub Class | 1,3-isoquinolinediones |
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Direct Parent | 1,3-isoquinolinediones |
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Alternative Parents | |
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Substituents | - 1,3-isoquinolinedione
- Isoquinolone
- Tetrahydroisoquinoline
- Benzenesulfonamide
- Benzenesulfonyl group
- Anisole
- Alkyl aryl ether
- Sulfonylurea
- Monocyclic benzene moiety
- Benzenoid
- Carboxylic acid imide, n-substituted
- Carboxylic acid imide
- Dicarboximide
- Aminosulfonyl compound
- Sulfonyl
- Organosulfonic acid or derivatives
- Organic sulfonic acid or derivatives
- Carboximidic acid derivative
- Carboxylic acid derivative
- Azacycle
- Organic 1,3-dipolar compound
- Ether
- Propargyl-type 1,3-dipolar organic compound
- Organopnictogen compound
- Organic oxygen compound
- Organic nitrogen compound
- Carbonyl group
- Organic oxide
- Hydrocarbon derivative
- Organosulfur compound
- Organonitrogen compound
- Organooxygen compound
- Aromatic heteropolycyclic compound
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Molecular Framework | Aromatic heteropolycyclic compounds |
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External Descriptors | Not Available |
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Biological Properties |
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Status | Detected and Not Quantified |
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Origin | Not Available |
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Cellular Locations | Not Available |
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Biofluid Locations | Not Available |
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Tissue Locations | Not Available |
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Pathways | Not Available |
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Applications | Not Available |
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Biological Roles | Not Available |
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Chemical Roles | Not Available |
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Physical Properties |
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State | Not Available |
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Appearance | Not Available |
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Experimental Properties | Property | Value |
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Melting Point | Not Available | Boiling Point | Not Available | Solubility | Not Available |
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Predicted Properties | |
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Spectra |
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Spectra | Spectrum Type | Description | Splash Key | View |
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Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | splash10-005a-9577510000-3108fb4977b04dda9052 | Spectrum | LC-MS/MS | LC-MS/MS Spectrum - LC-ESI-qTof , Positive | splash10-000i-0190000000-c5cf4b97bfa7d662bad1 | Spectrum | LC-MS/MS | LC-MS/MS Spectrum - LC-ESI-qTof , Positive | splash10-000i-0190000000-c5cf4b97bfa7d662bad1 | Spectrum | LC-MS/MS | LC-MS/MS Spectrum - , positive | splash10-0udi-0000190000-4154029e3d9f7cf38376 | Spectrum | LC-MS/MS | LC-MS/MS Spectrum - , positive | splash10-0udi-0422900000-64e5b1e1949d772ce08b | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-0fb9-3104890000-6d601bb3ac5c0bb0d993 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-0f6t-9415400000-5072a19e3375b586cd32 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0592-9511000000-5f06207a98a67edd3a20 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-004i-3030790000-ed0c108b8b565ee2d6d5 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-0gdi-3064910000-231d70cc839a771fa9a1 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-014j-9351200000-d2facf1a2bcbc9e3874c | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-0fb9-0003790000-4fd642bcd51b3cf42249 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-002r-2409420000-5e19673e35a1f29921fe | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0api-5912010000-7b7ab0e05bfc224d16e6 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-0fb9-0001890000-4fe7b42e77dda82aac00 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-016v-2219730000-278c19f511fcce113b06 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-052o-7228930000-d618542f2af31f90a808 | Spectrum |
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Toxicity Profile |
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Route of Exposure | Not Available |
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Mechanism of Toxicity | Not Available |
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Metabolism | Not Available |
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Toxicity Values | Not Available |
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Lethal Dose | Not Available |
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Carcinogenicity (IARC Classification) | Not Available |
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Uses/Sources | Not Available |
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Minimum Risk Level | Not Available |
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Health Effects | Not Available |
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Symptoms | Not Available |
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Treatment | Not Available |
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Concentrations |
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| Not Available |
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External Links |
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DrugBank ID | DB01251 |
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HMDB ID | HMDB0015381 |
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FooDB ID | Not Available |
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Phenol Explorer ID | Not Available |
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KNApSAcK ID | Not Available |
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BiGG ID | Not Available |
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BioCyc ID | Not Available |
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METLIN ID | Not Available |
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PDB ID | Not Available |
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Wikipedia Link | Gliquidone |
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Chemspider ID | 82719 |
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ChEBI ID | 441224 |
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PubChem Compound ID | 91610 |
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Kegg Compound ID | Not Available |
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YMDB ID | Not Available |
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ECMDB ID | Not Available |
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References |
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Synthesis Reference | Not Available |
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MSDS | Not Available |
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General References | Not Available |
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