Record Information |
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Version | 1.0 |
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Creation Date | 2016-05-20 16:15:30 UTC |
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Update Date | 2016-11-09 01:15:20 UTC |
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Accession Number | CHEM016120 |
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Identification |
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Common Name | 4,5',8-Trimethylpsoralen |
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Class | Small Molecule |
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Description | 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis. |
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Contaminant Sources | - FooDB Chemicals
- HMDB Contaminants - Urine
- IARC Carcinogens Group 3
- ToxCast & Tox21 Chemicals
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Contaminant Type | Not Available |
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Chemical Structure | |
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Synonyms | Value | Source |
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2',4,8-Trimethylpsoralen | ChEBI | 4,5',8-Trimethylpsoralen | ChEBI | 4,8,5'-Trimethylpsoralen | ChEBI | 6-Hydroxy-beta,2,7-trimethyl-5-benzofuranacrylic acid, delta-lactone | ChEBI | Trimethylpsoralen | ChEBI | Trioxisaleno | ChEBI | Trioxysalen | ChEBI | Trioxysalene | ChEBI | Trioxysalenum | ChEBI | Trisoralen | Kegg | 6-Hydroxy-b,2,7-trimethyl-5-benzofuranacrylate, delta-lactone | Generator | 6-Hydroxy-b,2,7-trimethyl-5-benzofuranacrylic acid, delta-lactone | Generator | 6-Hydroxy-beta,2,7-trimethyl-5-benzofuranacrylate, delta-lactone | Generator | 6-Hydroxy-β,2,7-trimethyl-5-benzofuranacrylate, δ-lactone | Generator | 6-Hydroxy-β,2,7-trimethyl-5-benzofuranacrylic acid, δ-lactone | Generator | 6-Hydroxy-b,2,7-trimethyl-5-benzofuranacrylate, δ-lactone | Generator, HMDB | 6-Hydroxy-b,2,7-trimethyl-5-benzofuranacrylic acid, δ-lactone | Generator, HMDB | Trioxisalenum | MeSH, HMDB | 2,5,9-Trimethyl-7H-furo(3,2-g)benzopyran-7-one | MeSH, HMDB | ICN brand OF trioxsalen | MeSH, HMDB |
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Chemical Formula | C14H12O3 |
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Average Molecular Mass | 228.243 g/mol |
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Monoisotopic Mass | 228.079 g/mol |
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CAS Registry Number | 3902-71-4 |
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IUPAC Name | 2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one |
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Traditional Name | trioxsalen |
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SMILES | CC1=CC2=CC3=C(OC(=O)C=C3C)C(C)=C2O1 |
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InChI Identifier | InChI=1S/C14H12O3/c1-7-4-12(15)17-14-9(3)13-10(6-11(7)14)5-8(2)16-13/h4-6H,1-3H3 |
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InChI Key | FMHHVULEAZTJMA-UHFFFAOYSA-N |
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Chemical Taxonomy |
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Description | belongs to the class of organic compounds known as psoralens. These are organic compounds containing a psoralen moiety, which consists of a furan fused to a chromenone to for 7H-furo[3,2-g]chromen-7-one. |
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Kingdom | Organic compounds |
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Super Class | Phenylpropanoids and polyketides |
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Class | Coumarins and derivatives |
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Sub Class | Furanocoumarins |
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Direct Parent | Psoralens |
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Alternative Parents | |
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Substituents | - Psoralen
- Benzopyran
- 1-benzopyran
- Benzofuran
- Pyranone
- Benzenoid
- Pyran
- Furan
- Heteroaromatic compound
- Lactone
- Oxacycle
- Organoheterocyclic compound
- Organooxygen compound
- Hydrocarbon derivative
- Organic oxide
- Organic oxygen compound
- Aromatic heteropolycyclic compound
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Molecular Framework | Aromatic heteropolycyclic compounds |
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External Descriptors | |
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Biological Properties |
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Status | Detected and Not Quantified |
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Origin | Not Available |
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Cellular Locations | Not Available |
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Biofluid Locations | Not Available |
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Tissue Locations | Not Available |
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Pathways | Not Available |
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Applications | Not Available |
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Biological Roles | Not Available |
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Chemical Roles | Not Available |
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Physical Properties |
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State | Not Available |
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Appearance | Not Available |
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Experimental Properties | Property | Value |
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Melting Point | Not Available | Boiling Point | Not Available | Solubility | Not Available |
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Predicted Properties | |
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Spectra |
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Spectra | Spectrum Type | Description | Splash Key | View |
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Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | splash10-0h10-0960000000-966d52d94de4b47d3acd | Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | Not Available | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-004i-0090000000-dcfc8fb3d1851500be83 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-0fb9-0090000000-9cf76c0cd3483f70877e | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0ik9-1930000000-364eb5a4711246301410 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-004i-0090000000-c823a179ff02e7127dc9 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-004i-0090000000-e4873a737dacdeebcb1a | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-003f-2920000000-c752e5912988325469f0 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-004i-0090000000-c89325e1a7192ec227f4 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-004i-0090000000-971e5b85c60e64223aa5 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0gvk-1930000000-c960ea7d61bacac4f3df | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-004i-0090000000-f0e0fc28215258fdeb31 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-004i-0190000000-11b09e07d8088345c5cb | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-004i-0690000000-74d27c4f6ef3bff95576 | Spectrum |
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Toxicity Profile |
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Route of Exposure | Not Available |
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Mechanism of Toxicity | Not Available |
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Metabolism | Not Available |
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Toxicity Values | Not Available |
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Lethal Dose | Not Available |
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Carcinogenicity (IARC Classification) | Not Available |
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Uses/Sources | Not Available |
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Minimum Risk Level | Not Available |
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Health Effects | Not Available |
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Symptoms | Not Available |
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Treatment | Not Available |
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Concentrations |
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| Not Available |
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External Links |
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DrugBank ID | DB04571 |
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HMDB ID | HMDB0015575 |
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FooDB ID | FDB001510 |
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Phenol Explorer ID | Not Available |
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KNApSAcK ID | C00002502 |
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BiGG ID | Not Available |
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BioCyc ID | Not Available |
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METLIN ID | Not Available |
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PDB ID | Not Available |
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Wikipedia Link | Trioxsalen |
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Chemspider ID | 5383 |
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ChEBI ID | 28329 |
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PubChem Compound ID | 5585 |
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Kegg Compound ID | C09314 |
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YMDB ID | Not Available |
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ECMDB ID | Not Available |
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References |
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Synthesis Reference | Not Available |
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MSDS | Not Available |
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General References | 1. van Coevorden AM, Kamphof WG, van Sonderen E, Bruynzeel DP, Coenraads PJ: Comparison of oral psoralen-UV-A with a portable tanning unit at home vs hospital-administered bath psoralen-UV-A in patients with chronic hand eczema: an open-label randomized controlled trial of efficacy. Arch Dermatol. 2004 Dec;140(12):1463-6. | 2. Higuchi M, Yamayoshi A, Kobori A, Yamaoka T, Murakami A: Synthesis and properties of photo-reactive antisense oligonucleotides containing 2'-O-psoralen-conjugated adenosine. Nucleic Acids Symp Ser (Oxf). 2005;(49):331-2. | 3. Thazhathveetil AK, Liu ST, Indig FE, Seidman MM: Psoralen conjugates for visualization of genomic interstrand cross-links localized by laser photoactivation. Bioconjug Chem. 2007 Mar-Apr;18(2):431-7. | 4. Goldenberg M, Welsh J, Haas R, Rideout DC, Cantor CR: Synthesis and properties of novel psoralen derivatives. Biochemistry. 1988 Sep 6;27(18):6971-6. doi: 10.1021/bi00418a045. | 5. Kaidbey KH, Kligman AM: Photopigmentation with trioxsalen. Arch Dermatol. 1974 May;109(5):674-7. | 6. Sehgal VN: Editorial: Effectiveness of trioxsalen therapy for vitiligo. Arch Dermatol. 1974 Dec;110(6):957-8. doi: 10.1001/archderm.1974.01630120089029. |
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