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Record Information
Version1.0
Creation Date2014-09-11 05:13:49 UTC
Update Date2016-11-09 01:09:11 UTC
Accession NumberCHEM003688
Identification
Common NamePotassium Chloride
ClassSmall Molecule
DescriptionA white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives.
Contaminant Sources
  • EAFUS Chemicals
  • FooDB Chemicals
  • HPV EPA Chemicals
  • OECD HPV Chemicals
  • T3DB toxins
Contaminant Type
  • Drug
  • Food Toxin
  • Household Toxin
  • Inorganic Compound
  • Natural Compound
Chemical Structure
Thumb
Synonyms
ValueSource
[KCL]ChEBI
KaliumchloridChEBI
Kaon-CL 10ChEBI
KClChEBI
Klor-CONChEBI
KlotrixChEBI
Monopotassium chlorideChEBI
Muriate OF potashChEBI
SylviteChEBI
K-DurKegg
Kaon-CLKegg
Muriic acid OF potashGenerator
Chloride, potassiumMeSH
Slow-KMeSH
Chemical FormulaClK
Average Molecular Mass74.551 g/mol
Monoisotopic Mass73.933 g/mol
CAS Registry Number7447-40-7
IUPAC Namepotassium chloride
Traditional Namepotassium chloride
SMILES[Cl-].[K+]
InChI IdentifierInChI=1S/ClH.K/h1H;/q;+1/p-1
InChI KeyWCUXLLCKKVVCTQ-UHFFFAOYSA-M
Chemical Taxonomy
Description belongs to the class of inorganic compounds known as alkali metal chlorides. These are inorganic compounds in which the largest halogen atom is Chlorine, and the heaviest metal atom is an alkali metal.
KingdomInorganic compounds
Super ClassMixed metal/non-metal compounds
ClassAlkali metal salts
Sub ClassAlkali metal chlorides
Direct ParentAlkali metal chlorides
Alternative Parents
Substituents
  • Alkali metal chloride
  • Inorganic chloride salt
  • Inorganic salt
Molecular FrameworkNot Available
External Descriptors
Biological Properties
StatusDetected and Not Quantified
OriginEndogenous
Cellular Locations
  • Cytoplasm
  • Extracellular
Biofluid LocationsNot Available
Tissue LocationsNot Available
PathwaysNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Physical Properties
StateSolid
AppearanceWhite powder.
Experimental Properties
PropertyValue
Melting Point770°C
Boiling PointNot Available
SolubilityFreely soluble
Predicted Properties
PropertyValueSource
logP0.2ChemAxon
pKa (Strongest Acidic)-7ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m³·mol⁻¹ChemAxon
Polarizability1.78 ųChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Spectra
SpectraNot Available
Toxicity Profile
Route of ExposurePotassium is a normal dietary constituent and under steady-state conditions the amount of potassium absorbed from the gastrointestinal tract is equal to the amount excreted in the urine.
Mechanism of ToxicitySupplemental potassium in the form of high potassium food or potassium chloride may be able to restore normal potassium levels.
MetabolismRoute of Elimination: Potassium is a normal dietary constituent and, under steady-state conditions, the amount of potassium absorbed from the gastrointestinal tract is equal to the amount excreted in the urine. Potassium depletion will occur whenever the rate of potassium loss through renal excretion and/or loss from the gastrointestinal tract exceeds the rate of potassium intake.
Toxicity ValuesNot Available
Lethal DoseNot Available
Carcinogenicity (IARC Classification)No indication of carcinogenicity to humans (not listed by IARC).
Uses/SourcesFor use as an electrolyte replenisher and in the treatment of hypokalemia.
Minimum Risk LevelNot Available
Health EffectsThe administration of oral potassium salts to persons with normal excretory mechanisms for potassium rarely causes serious hyperkalemia. However, if excretory mechanisms are impaired, of if potassium is administered too rapidly intravenously, potentially fatal hyperkalemia can result. It is important to recognize that hyperkalemia is usually asymptomatic and may be manifested only by an increased serum potassium concentration (6.5-8.0 mEq/L) and characteristic electrocardiographic changes (peaking of T-waves, loss of P-wave, depression of S-T segment, and prolongation of the QT interval). Late manifestations include muscle paralysis and cardiovascular collapse from cardiac arrest (9-12 mEq/L).
SymptomsNot Available
TreatmentEYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration.
Concentrations
Not Available
DrugBank IDDB00761
HMDB IDHMDB0303551
FooDB IDFDB015439
Phenol Explorer IDNot Available
KNApSAcK IDNot Available
BiGG IDNot Available
BioCyc IDKCL
METLIN IDNot Available
PDB IDNot Available
Wikipedia LinkPotassium_Chloride
Chemspider ID4707
ChEBI ID32588
PubChem Compound IDNot Available
Kegg Compound IDNot Available
YMDB IDNot Available
ECMDB IDNot Available
References
Synthesis Reference

Fritz Hagedorn, Gerd Peuschel, Arno Singewald, “Method for the production of potassium chloride with K.sub.2 O content of more than 55 weight percent.” U.S. Patent US5057208, issued July, 1955.

MSDSNot Available
General ReferencesNot Available