Nitrous oxide (CHEM003551)

IdentificationTaxonomyBiological PropertiesPhysical PropertiesToxicity ProfileSpectraConcentrationsLinksReferencesXML
Record Information
Version1.0
Creation Date2014-09-05 17:11:43 UTC
Update Date2026-05-14 18:22:54 UTC
Accession NumberCHEM003551
Identification
Common NameNitrous oxide
ClassSmall Molecule
DescriptionNitrous oxide is a flavouring ingredient and aerosol propellant for foods. It belongs to the family of Other Non-Metal Oxides. These are inorganic compounds containing an oxygen atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen belongs to the class of 'other non-metals'.
Contaminant Sources
  • EAFUS Chemicals
  • FooDB Chemicals
  • HPV EPA Chemicals
  • STOFF IDENT Compounds
  • T3DB toxins
Contaminant Type
  • Aerosol Spray Component
  • Flavouring Agent
  • Food Additive
  • Food Toxin
  • Household Toxin
  • Human Neurotoxin
  • Inorganic Compound
  • Metabolite
  • Non-Metal
  • Synthetic Compound
Chemical Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms
ValueSource
Diazyne 1-oxideChEBI
Dinitrogen monoxideChEBI
DistickstoffmonoxidChEBI
e942ChEBI
Factitious airChEBI
Gaz hilarantChEBI
LachgasChEBI
Laughing gasChEBI
N2OChEBI
Nitrogen protoxideChEBI
Nitrogenium oxydulatumChEBI
NNOChEBI
Oxyde nitreuxChEBI
Protoxyde d'azoteChEBI
R-744aChEBI
Stickstoff(I)-oxidChEBI
Dinitrogen oxideKegg
FEMA 2779HMDB
Gas, laughingHMDB
Hyponitrous acid anhydrideHMDB
NitralHMDB
Nitrogen hypoxideHMDB
Nitrogen monoxideHMDB
Nitrogen oxide (N2O)HMDB
Nitrous oxide (JP15/usp)HMDB
Nitrous oxide, compressedHMDB
Nitrous oxide, jan, usanHMDB
Nitrous oxide, refrigerated liquidHMDB
Nitrous-oxideHMDB
Oxide, nitrousHMDB
oxido NitrosoHMDB
Oxidodinitrogen(N--N)HMDB
StickdioxydHMDB
Nitrous oxideChEBI
Chemical FormulaN2O
Average Molecular Mass44.013 g/mol
Monoisotopic Mass44.001 g/mol
CAS Registry Number10024-97-2
IUPAC Namediazooxidane
Traditional Namenitrous oxide
SMILES[O-][N+]#N
InChI IdentifierInChI=1S/N2O/c1-2-3
InChI KeyGQPLMRYTRLFLPF-UHFFFAOYSA-N
Chemical Taxonomy
Description belongs to the class of inorganic compounds known as other non-metal nitrides. These are inorganic compounds of nitrogen where nitrogen has a formal oxidation state of -3, and the heaviest atom bonded to it belongs to the class of 'other non-metals'.
KingdomInorganic compounds
Super ClassHomogeneous non-metal compounds
ClassOther non-metal organides
Sub ClassOther non-metal nitrides
Direct ParentOther non-metal nitrides
Alternative Parents
Substituents
  • Other non-metal nitride
  • Inorganic nitride
  • Inorganic oxide
Molecular FrameworkNot Available
External Descriptors
Biological Properties
StatusDetected and Not Quantified
OriginExogenous
Cellular Locations
  • Cytoplasm
  • Extracellular
Biofluid LocationsNot Available
Tissue LocationsNot Available
PathwaysNot Available
Applications
Biological Roles
Chemical Roles
Physical Properties
StateGas
AppearanceNot Available
Experimental Properties
PropertyValue
Melting Point-90.6 °C
Boiling Point-88.48°C (184.67°K)
SolubilityNot Available
Predicted Properties
PropertyValueSource
logP-0.021ChemAxon
pKa (Strongest Basic)-6.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area54.46 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity27.67 m³·mol⁻¹ChemAxon
Polarizability2.54 ųChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyView
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positivesplash10-0006-9000000000-eb7b02e9ea0e132b0a58Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, PositiveNot AvailableSpectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0002-9000000000-2eee7435817186856ef7Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-001j-9000000000-d1a5381e3dd214cad7abSpectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-000t-9000000000-3ae2e01e3d626729760bSpectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-004l-9000000000-c53ff0d270e0310b3375Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-004i-9000000000-c8b9d8f80d3f41ad7f54Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-002f-9000000000-12c3fe456373daff732eSpectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0002-9000000000-f78d84fc2eb278e7bb4dSpectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0002-9000000000-f78d84fc2eb278e7bb4dSpectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0002-9000000000-f78d84fc2eb278e7bb4dSpectrum
Toxicity Profile
Route of ExposureNot Available
Mechanism of ToxicityNot Available
MetabolismNot Available
Toxicity ValuesNot Available
Lethal DoseNot Available
Carcinogenicity (IARC Classification)No indication of carcinogenicity to humans (not listed by IARC).
Uses/SourcesNot Available
Minimum Risk LevelNot Available
Health EffectsNot Available
SymptomsNot Available
TreatmentNot Available
Concentrations
Not Available
DrugBank IDDB06690
HMDB IDHMDB0035807
FooDB IDFDB014561
Phenol Explorer IDNot Available
KNApSAcK IDNot Available
BiGG IDNot Available
BioCyc IDNot Available
METLIN IDNot Available
PDB IDNot Available
Wikipedia LinkNitrous_oxide
Chemspider ID923
ChEBI ID17045
PubChem Compound ID948
Kegg Compound IDC00887
YMDB IDNot Available
ECMDB IDECMDB21255
References
Synthesis ReferenceNot Available
MSDSNot Available
General References
1. https://www.ncbi.nlm.nih.gov/pubmed/?term=11159233
2. https://www.ncbi.nlm.nih.gov/pubmed/?term=11811748
3. https://www.ncbi.nlm.nih.gov/pubmed/?term=15316643
4. https://www.ncbi.nlm.nih.gov/pubmed/?term=15644008
5. https://www.ncbi.nlm.nih.gov/pubmed/?term=16179535
6. https://www.ncbi.nlm.nih.gov/pubmed/?term=17093360
7. https://www.ncbi.nlm.nih.gov/pubmed/?term=18992971
8. https://www.ncbi.nlm.nih.gov/pubmed/?term=19910265
9. https://www.ncbi.nlm.nih.gov/pubmed/?term=21622873
10. https://www.ncbi.nlm.nih.gov/pubmed/?term=23643142
11. https://www.ncbi.nlm.nih.gov/pubmed/?term=7880215
12. Landauer B: [Anesthesia for ambulatory patients]. Fortschr Med. 1975 Nov 13;93(32):1573-80.
13. Niijima K, Seto A, Uehara H, Takenaka I, Kadoya T: [Anesthetic management for an adult patient with secundum atrial septal defect associated with a large left-to-right shunt]. Masui. 2000 Jun;49(6):646-8.
14. Erhardt W: [Anesthesia procedures in the rabbit]. Tierarztl Prax. 1984;12(3):391-402.
15. LICHTENSTEIN ME, METHOD H: Edmund Andrews, M.D., a biographical sketch with historical notes concerning nitrousoxide oxygen anesthesia. Q Bull Northwest Univ Med Sch. 1953;27(4):337-52.
16. Makkes PC, Jonker MJ, Turk T: [Nitrous-oxide sedation indispensable in the dental care of anxious people and the mentally impaired]. Ned Tijdschr Geneeskd. 2006 May 13;150(19):1055-8.
17. Lanz E, Zimmerschitt W: [Volume and pressure changes due to nitrousoxide diffusion in costumary and in low-pressure cuffs of endotracheal tubes (author's transl)]. Anaesthesist. 1976 Oct;25(10):491-8.
18. Yannai, Shmuel. (2004) Dictionary of food compounds with CD-ROM: Additives, flavors, and ingredients. Boca Raton: Chapman & Hall/CRC.