ContaminantDB: Cobalt(II) formate

Identification Taxonomy Biological Properties Physical Properties Toxicity Profile Spectra Concentrations Links References Targets (35)XML

Record Information

Version

1.0

Creation Date

2009-06-19 21:58:43 UTC

Update Date

2026-04-05 17:49:05 UTC

Accession Number

CHEM001203

Identification

Common Name

Cobalt(II) formate

Class

Small Molecule

Description

Cobalt(II) formate is a chemical compound of cobalt. Cobalt is a metallic element with the atomic number 27. It is found naturally in rocks, soil, water, plants, and animals. In small amounts cobalt is an essential element for life, as it is part of vitamin B12. However, excess exposure is known to exhibit toxic effects. (2, 3)

Contaminant Sources

Clean Air Act Chemicals
IARC Carcinogens Group 2B
T3DB toxins

Contaminant Type

Cobalt Compound
Industrial/Workplace Toxin
Organic Compound
Organometallic
Pollutant
Synthetic Compound

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
Cobalt(II) formic acid	Generator
Aluminum formate	MeSH
Ammonium tetraformate	MeSH
Cobaltous formate	MeSH
Formic acid, ammonium (4:1) salt	MeSH
Formic acid, copper (+2) salt	MeSH
Formic acid, cromium (+3), sodium (4:1:1) salt	MeSH
Formic acid, lead salt	MeSH
Formic acid, lithium salt	MeSH
Formic acid, magnesium salt	MeSH
Formic acid, strontium salt	MeSH
Nickel formate dihydrate	MeSH
Formate	MeSH
Formic acid, calcium salt	MeSH
Formic acid, copper salt	MeSH
Formic acid, copper, ammonium salt	MeSH
Formic acid, cromium (+3) salt	MeSH
Lead formate	MeSH
Potassium formate	MeSH
Strontium formate	MeSH
Calcium formate	MeSH
Chromic formate	MeSH
Formic acid, 14C-labeled	MeSH
Formic acid, ammonium (2:1) salt	MeSH
Formic acid, cesium salt	MeSH
Formic acid, cobalt (+2) salt	MeSH
Formic acid, nickel (+2) salt	MeSH
Formic acid, rubidium salt	MeSH
Formic acid, sodium salt	MeSH
Formic acid, sodium salt, 14C-labeled	MeSH
Formic acid, thallium (+1) salt	MeSH
Formic acid, zinc salt	MeSH
Methanoic acid	MeSH
Ammonium formate	MeSH
Cobalt(II) formate dihydrate	MeSH
Cupric formate	MeSH
Formic acid	MeSH
Formic acid, aluminum salt	MeSH
Formic acid, ammonium salt	MeSH
Formic acid, cadmium salt	MeSH
Formic acid, copper, nickel salt	MeSH
Formic acid, lead (+2) salt	MeSH
Formic acid, nickel salt	MeSH
Formic acid, potassium salt	MeSH
Formic acid, sodium salt, 13C-labeled	MeSH
Lithium formate	MeSH
Magnesium formate	MeSH
Nickel formate	MeSH
Sodium formate	MeSH
Zinc formate	MeSH

Chemical Formula

C₂H₂CoO₄

Average Molecular Mass

148.968 g/mol

Monoisotopic Mass

148.929 g/mol

CAS Registry Number

544-18-3

IUPAC Name

(formyloxy)cobaltio formate

Traditional Name

cobaltous formate

SMILES

O=CO[Co]OC=O

InChI Identifier

InChI=1S/2CH2O2.Co/c2*2-1-3;/h2*1H,(H,2,3);/q;;+2/p-2

InChI Key

PFQLIVQUKOIJJD-UHFFFAOYSA-L

Chemical Taxonomy

Description

belongs to the class of organic compounds known as carboxylic acid salts. These are ionic derivatives of carboxylic acid.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Carboxylic acid derivatives

Direct Parent

Carboxylic acid salts

Alternative Parents

Substituents

Carboxylic acid salt
Organic transition metal salt
Monocarboxylic acid or derivatives
Carboxylic acid
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organic cobalt salt
Organic salt
Organooxygen compound
Carbonyl group
Aliphatic acyclic compound

Molecular Framework

Not Available

External Descriptors

Not Available

Biological Properties

Status

Detected and Not Quantified

Origin

Exogenous

Cellular Locations

Cytoplasm
Extracellular

Biofluid Locations

Not Available

Tissue Locations

Not Available

Pathways

Not Available

Applications

Not Available

Biological Roles

Not Available

Chemical Roles

Not Available

Physical Properties

State

Solid

Appearance

Red crystals.

Experimental Properties

Property	Value
Melting Point	Not Available
Boiling Point	Not Available
Solubility	Soluble in water. Insoluble in alcohol.

Predicted Properties

Property	Value	Source
Water Solubility	314 g/L	ALOGPS
logP	-0.1	ALOGPS
logP	-0.72	ChemAxon
logS	0.32	ALOGPS
pKa (Strongest Basic)	-6.2	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	52.6 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	14.45 m³·mol⁻¹	ChemAxon
Polarizability	8.24 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0002-0900000000-793148643357979f3fa3	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0f6t-0900000000-482848e26f2182acae09	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-00mp-9300000000-982f3698c78054297f26	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-00kb-0900000000-e37539e20a3277d24f78	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0002-2900000000-f6df24b0fc52297779ee	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0006-9400000000-c9fcb09ff7b01fbc4582	Spectrum

Toxicity Profile

Route of Exposure

Inhalation (2) ; oral (2) ; dermal (2)

Mechanism of Toxicity

Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, causing increased lipid peroxidation, DNA damage, and inducing certain enzymes that lead to cell apoptosis. Cobalt has also been shown to block inorganic calcium channels, possibly impairing neurotransmission. Cobalt can also chelate lipoic acids, impairing oxidation of pyruvate or fatty acids. In addition, cobalt may inhibit DNA repair by interacting with zinc finger DNA repair proteins, and has also been shown to inhibit heme synthesis and glucose metabolism. Cobalt may activate specific helper T-lymphocyte cells and interact directly with immunologic proteins, such as antibodies (IgA and IgE) or Fc receptors, resulting in immunosensitization. (2)

Metabolism

Cobalt is absorbed though the lungs, gastrointestinal tract, and skin. Since it is a component of the vitamin B12 (cyanocobalamin), it is distributed to most tissues of the body. It is transported in the blood, often bound to albumin, with the highest levels being found in the liver and kidney. Cobalt is excreted mainly in the urine and faeces. (2)

Toxicity Values

Not Available

Lethal Dose

Not Available

Carcinogenicity (IARC Classification)

2B, possibly carcinogenic to humans. (5)

Uses/Sources

Not Available

Minimum Risk Level

Chronic Inhalation: 0.0001 mg/m3 (4) Intermediate Oral: 0.01 mg/kg/day (4)

Health Effects

Exposure to high amount of cobalt can cause heart, lung, kidney, and liver damage. Skin contact is known to result in contact dermatitis. Cobalt may also have mutagenic and carcinogenic effects. (2, 3)

Symptoms

Cobalt inhalation can cause asthma-like breathing problems. Skin contact is known to result in contact dermatitis, which is characterized by irritation and rashes. Ingesting large amounts of cobalt may cause nausea and vomiting. (6)

Treatment

Treatment of cobalt poisoning is symptomatic. (2)

Concentrations

Not Available

External Links

DrugBank ID

Not Available

HMDB ID

Not Available

FooDB ID

Not Available

Phenol Explorer ID

Not Available

KNApSAcK ID

Not Available

BiGG ID

Not Available

BioCyc ID

Not Available

METLIN ID

Not Available

PDB ID

Not Available

Wikipedia Link

Cobalt(II) formate

Chemspider ID

Not Available

ChEBI ID

Not Available

PubChem Compound ID

10998

Kegg Compound ID

Not Available

YMDB ID

Not Available

ECMDB ID

Not Available

References

Synthesis Reference

Not Available

MSDS

Not Available

General References

Not Available

Cobalt(II) formate (CHEM001203)

Structure for CHEM001203: Cobalt(II) formate