Uranium pentafluoride (CHEM000999)

IdentificationTaxonomyBiological PropertiesPhysical PropertiesToxicity ProfileSpectraConcentrationsLinksReferencesTargets (1)XML
Record Information
Version1.0
Creation Date2009-06-19 21:58:23 UTC
Update Date2026-04-05 20:39:15 UTC
Accession NumberCHEM000999
Identification
Common NameUranium pentafluoride
ClassSmall Molecule
DescriptionUranium pentafluoride is a fluoride of uranium. Uranium is a chemical element that has the symbol U and atomic number 92. It is a normal part of rocks, soil, air, and water, and occurs in nature in the form of minerals. (5, 6)
Contaminant Sources
  • T3DB toxins
Contaminant Type
  • Fluoride Compound
  • Industrial/Workplace Toxin
  • Inorganic Compound
  • Pollutant
  • Radioactive
  • Synthetic Compound
  • Uranium Compound
Chemical Structure
Thumb
MOLSDFPDBSMILESInChI
SynonymsNot Available
Chemical FormulaF5U
Average Molecular Mass333.021 g/mol
Monoisotopic Mass333.043 g/mol
CAS Registry Number10049-14-6
IUPAC Namepentafluorouranium
Traditional Nameuranium pentafluoride
SMILESF[U](F)(F)(F)F
InChI IdentifierInChI=1S/5FH.U/h5*1H;/q;;;;;+5/p-5
InChI KeyJNVYCANIFQDNST-UHFFFAOYSA-I
Chemical Taxonomy
Description belongs to the class of inorganic compounds known as actinide fluorides. These are inorganic compounds in which the largest halogen atom is fluorine, and the heaviest metal atom is an actinide.
KingdomInorganic compounds
Super ClassMixed metal/non-metal compounds
ClassActinide salts
Sub ClassActinide fluorides
Direct ParentActinide fluorides
Alternative Parents
Substituents
  • Actinide fluoride
  • Inorganic salt
Molecular FrameworkNot Available
External DescriptorsNot Available
Biological Properties
StatusDetected and Not Quantified
OriginExogenous
Cellular Locations
  • Cytoplasm
  • Extracellular
Biofluid LocationsNot Available
Tissue LocationsNot Available
PathwaysNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Physical Properties
StateSolid
AppearanceWhite powder.
Experimental Properties
PropertyValue
Melting Point1036°C
Boiling PointNot Available
SolubilityNot Available
Predicted Properties
PropertyValueSource
logP1.71ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity7.51 m³·mol⁻¹ChemAxon
Polarizability4.16 ųChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-001i-0009000000-cf0b38c4c1907f68b7c8Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-001i-0009000000-cf0b38c4c1907f68b7c8Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-001i-0009000000-cf0b38c4c1907f68b7c8Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-001i-0009000000-17c193146ff98877e9efSpectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-001i-0009000000-17c193146ff98877e9efSpectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-001i-0009000000-17c193146ff98877e9efSpectrum
Toxicity Profile
Route of ExposureOral (6) ; inhalation (6) ; dermal (6)
Mechanism of ToxicityUranium is combined with either bicarbonate or a plasma protein in the blood but once in the kidney, it is released and forms complexes with phosphate ligands and proteins in the tubular wall, causing damage. Uranium may also inhibit both sodium transport-dependent and independent ATP utilization and mitochondrial oxidative phosphorylation in the renal proximal tubule. Uranium causes respiratory diseases by damaging alveolar epithelium type II cells in the lungs. Uranium induces c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) activation, which in turn induces tumor necrosis factor alpha (TNF-alpha) secretion and generates and inflammatory response in the lungs. Studies have shown that the more soluble the uranium salt, the more toxic it is. Ionizing radiation produced by uranium damages the DNA, resulting in gene mutations and chromosomal aberrations. This can both both initiate and promote carcinogenesis, and interfere with reproduction and development. (6, 1)
MetabolismUranium is absorbed in low amounts via oral, inhalation, and dermal routes. Uranium in body fluids generally exists as the uranyl ion (UO2)2+ complexed with anions, such as citrate and bicarbonate, or plasma proteins. Uranium preferentially distributes to bone, liver, and kidney. The large majority of uranium that enters the body is not absorbed and is eliminated from the body via the urine and faeces. (5)
Toxicity ValuesNot Available
Lethal DoseNot Available
Carcinogenicity (IARC Classification)Uranium: Group 1, carcinogenic to humans (4)
Uses/SourcesNot Available
Minimum Risk LevelIntermediate Inhalation: 0.0004 mg/m3 (Soluble uranium salts) (3) Chronic Inhalation: 0.0003 mg/m3 (Soluble uranium salts) (3) Intermediate Oral: 0.002 mg/kg/day (Soluble uranium salts) (3) Intermediate Inhalation: 0.008 mg/m3 (Insoluble uranium compounds) (3)
Health EffectsUranium primarily damages the kidney, but may also damage the lungs, central nervous system, and immune system. Uranium's radioactivity is believed to damage the DNA, resulting in carcinogenic effects and reproductive and developmental damage. (5, 6)
SymptomsIngestion of uranium may cause vomiting and diarrhea. (5)
TreatmentEYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration.
Concentrations
Not Available
DrugBank IDNot Available
HMDB IDNot Available
FooDB IDNot Available
Phenol Explorer IDNot Available
KNApSAcK IDNot Available
BiGG IDNot Available
BioCyc IDNot Available
METLIN IDNot Available
PDB IDNot Available
Wikipedia LinkUranium pentafluoride
Chemspider IDNot Available
ChEBI IDNot Available
PubChem Compound ID83723
Kegg Compound IDNot Available
YMDB IDNot Available
ECMDB IDNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General ReferencesNot Available