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Record Information
Version1.0
Creation Date2009-03-27 01:18:55 UTC
Update Date2016-11-09 01:08:20 UTC
Accession NumberCHEM000664
Identification
Common NameZinc peroxide
ClassSmall Molecule
DescriptionZinc peroxide (ZnO2) appears as a bright yellow powder at room temperature. It was historically used as a surgical antiseptic. More recently zinc peroxide has also been used as an oxidant in explosives and pyrotechnic mixtures. Its properties have been described as a transition between ionic and covalent peroxides. Zinc peroxide is very hazardous in case of skin contact, of eye contact, ingestion, or inhalation. It has been shown to be corrosive to skin. Prolonged exposure may result in skin burns and ulcerations. Over-exposure by inhalation may cause respiratory irritation. Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering. Zinc Peroxide is toxic to lungs and mucous membranes. Repeated or prolonged exposure can produce organ damage. Repeated or prolonged inhalation of vapors may lead to chronic respiratory irritation.
Contaminant Sources
  • T3DB toxins
Contaminant Type
  • Industrial/Workplace Toxin
  • Inorganic Compound
  • Lachrymator
  • Synthetic Compound
  • Zinc Compound
Chemical Structure
Thumb
SynonymsNot Available
Chemical FormulaH2O2Zn
Average Molecular Mass99.424 g/mol
Monoisotopic Mass97.935 g/mol
CAS Registry Number1314-22-3
IUPAC Nameperoxol zinc
Traditional Namehydrogen peroxide zinc
SMILES[Zn].OO
InChI IdentifierInChI=1S/H2O2.Zn/c1-2;/h1-2H;
InChI KeyDLINORNFHVEIFE-UHFFFAOYSA-N
Chemical Taxonomy
Description belongs to the class of inorganic compounds known as miscellaneous mixed metal/non-metals. These are inorganic compounds containing non-metal as well as metal atoms but not belonging to afore mentioned classes.
KingdomInorganic compounds
Super ClassMixed metal/non-metal compounds
ClassMiscellaneous mixed metal/non-metals
Sub ClassNot Available
Direct ParentMiscellaneous mixed metal/non-metals
Alternative Parents
Substituents
  • Inorganic salt
  • Miscellaneous mixed metal/non-metal
Molecular FrameworkNot Available
External DescriptorsNot Available
Biological Properties
StatusDetected and Not Quantified
OriginExogenous
Cellular Locations
  • Acrosome
  • Actin Cytoskeleton
  • Caveolae
  • Cell junction
  • Cell surface
  • Cytoplasm
  • Cytoskeleton
  • Cytosol
  • Endoplasmic reticulum
  • Extracellular
  • Extracellular matrix
  • Focal adhesion
  • Lysosome
  • Microsome
  • Microtubule
  • Mitochondrial Intermembrane Space
  • Mitochondrial Matrix
  • Mitochondrial Membrane
  • Mitochondrion
  • Nerve Fiber
  • Nuclear Matrix
  • Nucleolus
  • Peroxisome
  • Plasma Membrane
  • Ribosome
  • Synaptic Vesicle
  • Tubulin
Biofluid LocationsNot Available
Tissue LocationsNot Available
Pathways
NameSMPDB LinkKEGG Link
ApoptosisNot Availablemap04210
Cell cycleNot Availablemap04110
Oxidative phosphorylationNot Availablemap00190
Base excision repairNot Availablemap03410
EndocytosisNot Availablemap04144
TetracyclinesNot AvailableNot Available
Rna polymeraseNot Availablemap03020
ProteasomeNot AvailableNot Available
Non-homologous end-joiningNot Availablemap03450
Tryptophan MetabolismSMP00063 map00380
Pentose Phosphate PathwaySMP00031 map00030
Nitrogen MetabolismNot AvailableNot Available
Insulin secretionNot Availablemap04911
Homologous recombinationNot Availablemap03440
Glutathione MetabolismSMP00015 map00480
Dna replicationNot Availablemap03030
Carbon MetabolismNot AvailableNot Available
Ubiquitin mediated proteolysisNot Availablemap04120
Sulfur metabolismNot Availablemap00920
SpliceosomeNot Availablemap03040
PhagosomeNot Availablemap04145
Mismatch repairNot Availablemap03430
MelanogenesisNot Availablemap04916
Long-term potentiationNot Availablemap04720
Insulin signaling pathwayNot Availablemap04910
Fatty acid MetabolismSMP00051 map00071
Antifungal AgentsNot AvailableNot Available
Allograft RejectionNot AvailableNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Physical Properties
StateSolid
AppearanceWhite-yellow crystals.
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted Properties
PropertyValueSource
logP-0.45ChemAxon
pKa (Strongest Acidic)11.52ChemAxon
pKa (Strongest Basic)-4.2ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area40.46 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity5.13 m³·mol⁻¹ChemAxon
Polarizability2.29 ųChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0002-9000000000-9be9156afd3141e6f36eView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0002-9000000000-9be9156afd3141e6f36eView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0002-9000000000-9be9156afd3141e6f36eView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0002-9000000000-12c106d60aa037bcb6c2View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0002-9000000000-12c106d60aa037bcb6c2View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0002-9000000000-12c106d60aa037bcb6c2View in MoNA
Toxicity Profile
Route of ExposureInhalation (3) ; oral (3) ; dermal (3)
Mechanism of ToxicityAnaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. (2, 3, 1)
MetabolismZinc can enter the body through the lungs, skin, and gastrointestinal tract. Intestinal absorption of zinc is controlled by zinc carrier protein CRIP. Zinc also binds to metallothioneins, which help prevent absorption of excess zinc. Zinc is widely distributed and found in all tissues and tissues fluids, concentrating in the liver, gastrointestinal tract, kidney, skin, lung, brain, heart, and pancreas. In the bloodstream zinc is found bound to carbonic anhydrase in erythrocytes, as well as bound to albumin, _2-macroglobulin, and amino acids in the the plasma. Albumin and amino acid bound zinc can diffuse across tissue membranes. Zinc is excreted in the urine and faeces. (3)
Toxicity ValuesNot Available
Lethal DoseNot Available
Carcinogenicity (IARC Classification)No indication of carcinogenicity to humans (not listed by IARC).
Uses/SourcesZinc peroxide is used as a bleaching and curing agent, and as an additive in antiseptic ointments. (4)
Minimum Risk LevelIntermediate Oral: 0.3 mg/kg/day (6) Chronic Oral: 0.3 mg/kg/day (6)
Health EffectsChronic exposure to zinc causes anemia, atazia, lethargy, and decreases the level of good cholesterol in the body. It is also believed to cause pancreatic and reproductive damage. (3)
SymptomsIngestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. (3)
TreatmentZinc poisoning is treated symptomatically, often by administering fluids such as water or milk, or with gastric lavage. (3)
Concentrations
Not Available
DrugBank IDNot Available
HMDB IDNot Available
FooDB IDNot Available
Phenol Explorer IDNot Available
KNApSAcK IDNot Available
BiGG IDNot Available
BioCyc IDNot Available
METLIN IDNot Available
PDB IDNot Available
Wikipedia LinkZinc peroxide
Chemspider IDNot Available
ChEBI IDNot Available
PubChem Compound ID14809
Kegg Compound IDNot Available
YMDB IDNot Available
ECMDB IDNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General ReferencesNot Available