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Record Information
Creation Date2009-03-27 00:56:27 UTC
Update Date2016-11-09 01:08:20 UTC
Accession NumberCHEM000658
Common NameZinc hydroxide
ClassSmall Molecule
DescriptionZinc hydroxide is a hydroxide of zinc, with the chemical formula Zn(OH)2. It is used in surgical dressings. Zinc is a metallic element with the atomic number 30. It is found in nature most often as the mineral sphalerite. It also occurs naturally as 3 rare minerals: wн_lfingite (orthorhombic), ashoverite and sweetite (both tetragonal).Though excess zinc in harmful, in smaller amounts it is an essential element for life, as it is a cofactor for over 300 enzymes and is found in just as many transcription factors. (2, 3, 4)
Contaminant Sources
  • HPV EPA Chemicals
  • T3DB toxins
Contaminant Type
  • Industrial/Workplace Toxin
  • Inorganic Compound
  • Synthetic Compound
  • Zinc Compound
Chemical Structure
SynonymsNot Available
Chemical FormulaH2O2Zn
Average Molecular Mass99.424 g/mol
Monoisotopic Mass97.935 g/mol
CAS Registry Number20427-58-1
IUPAC Namezinc(2+) ion dihydroxide
Traditional Namezinc(2+) ion dihydroxide
InChI IdentifierInChI=1S/2H2O.Zn/h2*1H2;/q;;+2/p-2
Chemical Taxonomy
Description belongs to the class of inorganic compounds known as transition metal hydroxides. These are inorganic compounds in which the largest oxoanion is hydroxide, and in which the heaviest atom not in an oxoanion is a transition metal.
KingdomInorganic compounds
Super ClassMixed metal/non-metal compounds
ClassTransition metal oxoanionic compounds
Sub ClassTransition metal hydroxides
Direct ParentTransition metal hydroxides
Alternative Parents
  • Transition metal hydroxide
  • Inorganic hydride
  • Inorganic oxide
  • Inorganic salt
Molecular FrameworkNot Available
External DescriptorsNot Available
Biological Properties
StatusDetected and Not Quantified
Cellular Locations
  • Cell surface
  • Cytoplasm
  • Endoplasmic reticulum
  • Extracellular
  • Extracellular matrix
  • Microsome
  • Microtubule
  • Mitochondrial Matrix
  • Mitochondrion
  • Nuclear Membrane
  • Plasma Membrane
  • Secretory vesicle
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApoptosisNot Availablemap04210
PenicillinsNot AvailableNot Available
Osteoclast differentiationNot Availablemap04380
Cell cycleNot Availablemap04110
Purine MetabolismSMP00050 map00230
Nitrogen MetabolismNot AvailableNot Available
EndocytosisNot Availablemap04144
Dna replicationNot Availablemap03030
Base excision repairNot Availablemap03410
Antiulcer DrugsNot AvailableNot Available
Antifungal AgentsNot AvailableNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Physical Properties
AppearanceWhite powder.
Experimental Properties
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted Properties
pKa (Strongest Acidic)15.7ChemAxon
pKa (Strongest Basic)-1.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area0 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity13.91 m³·mol⁻¹ChemAxon
Polarizability1.19 ųChemAxon
Number of Rings0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0002-9000000000-9be9156afd3141e6f36eView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0002-9000000000-9be9156afd3141e6f36eView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0002-9000000000-9be9156afd3141e6f36eView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0002-9000000000-12c106d60aa037bcb6c2View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0002-9000000000-12c106d60aa037bcb6c2View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0002-9000000000-12c106d60aa037bcb6c2View in MoNA
Toxicity Profile
Route of ExposureInhalation (3) ; oral (3) ; dermal (3)
Mechanism of ToxicityAnaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. (2, 3, 1)
MetabolismZinc can enter the body through the lungs, skin, and gastrointestinal tract. Intestinal absorption of zinc is controlled by zinc carrier protein CRIP. Zinc also binds to metallothioneins, which help prevent absorption of excess zinc. Zinc is widely distributed and found in all tissues and tissues fluids, concentrating in the liver, gastrointestinal tract, kidney, skin, lung, brain, heart, and pancreas. In the bloodstream zinc is found bound to carbonic anhydrase in erythrocytes, as well as bound to albumin, _2-macroglobulin, and amino acids in the the plasma. Albumin and amino acid bound zinc can diffuse across tissue membranes. Zinc is excreted in the urine and faeces. (3)
Toxicity ValuesNot Available
Lethal DoseNot Available
Carcinogenicity (IARC Classification)No indication of carcinogenicity to humans (not listed by IARC).
Uses/SourcesZinc hydroxide is used in surgical dressings. (4)
Minimum Risk LevelIntermediate Oral: 0.3 mg/kg/day (6) Chronic Oral: 0.3 mg/kg/day (6)
Health EffectsChronic exposure to zinc causes anemia, atazia, lethargy, and decreases the level of good cholesterol in the body. It is also believed to cause pancreatic and reproductive damage. (3)
SymptomsIngestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. (3)
TreatmentZinc poisoning is treated symptomatically, often by administering fluids such as water or milk, or with gastric lavage. (3)
Not Available
DrugBank IDNot Available
HMDB IDNot Available
FooDB IDNot Available
Phenol Explorer IDNot Available
KNApSAcK IDNot Available
BiGG IDNot Available
BioCyc IDNot Available
METLIN IDNot Available
PDB IDNot Available
Wikipedia LinkZinc hydroxide
Chemspider IDNot Available
ChEBI IDNot Available
PubChem Compound ID9812759
Kegg Compound IDNot Available
YMDB IDNot Available
ECMDB IDNot Available
Synthesis ReferenceNot Available
MSDSNot Available
General ReferencesNot Available