ContaminantDB: Cadmium chloride

Identification Taxonomy Biological Properties Physical Properties Toxicity Profile Spectra Concentrations Links References Targets (22)XML

Record Information

Version

1.0

Creation Date

2009-03-06 18:58:38 UTC

Update Date

2026-04-05 16:11:01 UTC

Accession Number

CHEM000316

Identification

Common Name

Cadmium chloride

Class

Small Molecule

Description

Cadmium chloride is a chloride of cadmium that is used mainly in the synthesis of other cadmium compounds. Cadmium is a transition metal and chemical element with the symbol Cd and atomic number 48. It is found naturally in the earth's crust, though rarely on it's own. (4, 10)

Contaminant Sources

Clean Air Act Chemicals
HPV EPA Chemicals
IARC Carcinogens Group 1
T3DB toxins
ToxCast & Tox21 Chemicals

Contaminant Type

Cadmium Compound
Industrial/Workplace Toxin
Inorganic Compound
Pollutant
Synthetic Compound

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
[CDCL2]	ChEBI
Caddy	ChEBI
CDCL2	ChEBI
Dichlorocadmium	ChEBI
Kadmiumchlorid	ChEBI
Dichloride, cadmium	MeSH
Cadmium dichloride	MeSH
Chloride, cadmium	MeSH

Chemical Formula

CdCl₂

Average Molecular Mass

183.317 g/mol

Monoisotopic Mass

183.841 g/mol

CAS Registry Number

10108-64-2

IUPAC Name

dichlorocadmium

Traditional Name

cadmium chloride

SMILES

Cl[Cd]Cl

InChI Identifier

InChI=1S/Cd.2ClH/h;2*1H/q+2;;/p-2

InChI Key

YKYOUMDCQGMQQO-UHFFFAOYSA-L

Chemical Taxonomy

Description

belongs to the class of inorganic compounds known as transition metal chlorides. These are inorganic compounds in which the largest halogen atom is Chlorine, and the heaviest metal atom is a transition metal.

Kingdom

Inorganic compounds

Super Class

Mixed metal/non-metal compounds

Class

Transition metal salts

Sub Class

Transition metal chlorides

Direct Parent

Transition metal chlorides

Alternative Parents

Substituents

Transition metal chloride
Inorganic chloride salt
Inorganic cadmium salt
Inorganic salt

Molecular Framework

Not Available

External Descriptors

Biological Properties

Status

Detected and Not Quantified

Origin

Exogenous

Cellular Locations

Cytoplasm
Extracellular

Biofluid Locations

Not Available

Tissue Locations

Not Available

Pathways

Not Available

Applications

Not Available

Biological Roles

Not Available

Chemical Roles

Not Available

Physical Properties

State

Solid

Appearance

White crystals.

Experimental Properties

Property	Value
Melting Point	564°C
Boiling Point	Not Available
Solubility	Not Available

Predicted Properties

Property	Value	Source
logP	0.7	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	0	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	0 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	12.27 m³·mol⁻¹	ChemAxon
Polarizability	7.27 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-001i-0900000000-fd3ece8807315a6172f1	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-001i-0900000000-fd3ece8807315a6172f1	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-001i-0900000000-fd3ece8807315a6172f1	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-001i-0900000000-11ed9c099f9a06c091dc	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-001i-0900000000-11ed9c099f9a06c091dc	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-001i-0900000000-11ed9c099f9a06c091dc	Spectrum

Toxicity Profile

Route of Exposure

Oral (4) ; inhalation (4) ; dermal (4)

Mechanism of Toxicity

Cadmium initially binds to metallothionein and is transported to the kidney. Toxic effects are observed once the concentration of cadmium exceeds that of available metallothionein, and it has also been shown that the cadmium-metallothionein complex may be damaging. Accumulation of cadmium in the kidney results in increased excretion of vital low and high weight molecular proteins. Cadmium is a high affinity zinc analog and can interfere in its biological processes. It also binds to and activates the estrogen receptor, likely stimulating the growth of certain types of cancer cells and causing other estrogenic effects, such as reproductive dysfunction. Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (5, 1, 2, 3)

Metabolism

Cadmium is absorbed from oral, inhalation, and dermal routes. Cadmium initially binds to metallothionein and albumin and is transported mainly to the kidney and liver. Toxic effects are observed once the concentration of cadmium exceeds that of available metallothionein, and it has also been shown that the cadmium-metallothionein complex may be damaging. Cadmium is not known to undergo any direct metabolic conversion and is excreted unchanged, mainly in the urine. (4)

Toxicity Values

LD50: 88 mg/kg (Oral, Rat) (11) LD50: 1800 ug/kg (Intraperitoneal, Rat) (11) LD50: 3200 ug/kg (Subcutaneous, Mouse) (11) LD50: 3500 ug/kg Intravenous, Mouse) (11)

Lethal Dose

Not Available

Carcinogenicity (IARC Classification)

1, carcinogenic to humans. (8)

Uses/Sources

Cadmium chloride is used in the dyeing and printing of fabrics, in photography, in producing electronics components and in the synthesis of other cadmium compounds. (10)

Minimum Risk Level

Acute Inhalation: 0.00003 mg/m3 (7) Chronic Inhalation: 0.00001 mg/m3 (7) Intermediate Oral: 0.0005 mg/kg/day (7) Chronic Oral: 0.0001 mg/kg/day (7)

Health Effects

Chronic exposure to cadmium fumes can cause chemical pneumonitis, pulmonary edema, and lung diseases such as bronchitis and emphysema. Cadmium also accumulates in the kidneys, causing permanent damage. Loss of bone density also occurs. (4)

Symptoms

Acute inhalation of cadmium fumes results in metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Ingestion of cadmium causes vomiting and diarrhea. (4)

Treatment

Cadmium poisoning is treated by removal from exposure and supportive care. If ingested, induced vomiting or gastric lavage may be performed. (9)

Concentrations

Not Available

External Links

DrugBank ID

Not Available

HMDB ID

Not Available

FooDB ID

Not Available

Phenol Explorer ID