ContaminantDB: Neptunium-237

Identification Taxonomy Biological Properties Physical Properties Toxicity Profile Spectra Concentrations Links References Targets (1)XML

Record Information

Version

1.0

Creation Date

2009-03-06 18:58:09 UTC

Update Date

2016-11-09 01:08:10 UTC

Accession Number

CHEM000126

Identification

Common Name

Neptunium-237

Class

Small Molecule

Description

Neptunium is a chemical element with the symbol Np and atomic number 93. A radioactive metallic element, neptunium is the first transuranic element and belongs to the actinide series. Its most stable isotope, 237Np, is a by-product of nuclear reactors and plutonium production and it can be used as a component in neutron detection equipment. Neptunium is also found in trace amounts in uranium ores due to transmutation reactions. (2)

Contaminant Sources

IARC Carcinogens Group 1
T3DB toxins

Contaminant Type

Industrial/Workplace Toxin
Inorganic Compound
Metal
Pollutant
Radioactive
Radioactive Isotope
Synthetic Compound

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
NP-237 Radioisotope	MeSH
237np Radioisotope	MeSH

Chemical Formula

Average Molecular Mass

237.048 g/mol

Monoisotopic Mass

237.048 g/mol

CAS Registry Number

13994-20-2

IUPAC Name

(²³⁷Np)neptunium

Traditional Name

(²³⁷Np)neptunium

SMILES

[237Np]

InChI Identifier

InChI=1S/Np/i1+0

InChI Key

LFNLGNPSGWYGGD-IGMARMGPSA-N

Chemical Taxonomy

Description

belongs to the class of inorganic compounds known as homogeneous actinide compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom.

Kingdom

Inorganic compounds

Super Class

Homogeneous metal compounds

Class

Homogeneous actinide compounds

Sub Class

Not Available

Direct Parent

Homogeneous actinide compounds

Alternative Parents

Not Available

Substituents

Homogeneous actinide

Molecular Framework

Not Available

External Descriptors

Not Available

Biological Properties

Status

Detected and Not Quantified

Origin

Exogenous

Cellular Locations

Cytoplasm
Extracellular

Biofluid Locations

Not Available

Tissue Locations

Not Available

Pathways

Not Available

Applications

Not Available

Biological Roles

Not Available

Chemical Roles

Not Available

Physical Properties

State

Solid

Appearance

Silver metal.

Experimental Properties

Property	Value
Melting Point	Not Available
Boiling Point	Not Available
Solubility	Not Available

Predicted Properties

Property	Value	Source
logP	0	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	0	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	0 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	0 m³·mol⁻¹	ChemAxon
Polarizability	1.78 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-000i-0090000000-46f10cba410914d93b10	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-000i-0090000000-46f10cba410914d93b10	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-000i-0090000000-46f10cba410914d93b10	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-000i-0090000000-745220007a4fbbe965f9	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-000i-0090000000-745220007a4fbbe965f9	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-000i-0090000000-745220007a4fbbe965f9	Spectrum

Toxicity Profile

Route of Exposure

Oral (1) ; Inhalation (1)

Mechanism of Toxicity

The ionizing radiation produced by neptunium causes cellular damage that includes DNA breakage, accurate or inaccurate repair, apoptosis, gene mutations, chromosomal change, and genetic instability. This leads to loss of normal cell and tissue homeostasis, and development of malignancy. Ionizing radiation that does not directly damage DNA can produce reactive oxygen intermediates that directly affect the stability of p53, an important enzyme in cell-cycle regulation, and produce oxidative damage to individual bases in DNA and point mutations by mispairing during DNA replication. (1)

Metabolism

Not Available

Toxicity Values

Not Available

Lethal Dose

Not Available

Carcinogenicity (IARC Classification)

1, carcinogenic to humans. (4)

Uses/Sources

237Np is a by-product of nuclear reactors and plutonium production and it can be used as a component in neutron detection equipment. (2)

Minimum Risk Level

Not Available

Health Effects

237-Neptunium's radioactivity can cause cancer. (1)

Symptoms

Exposure to high doses of ionizing radiation results in acute radiation syndrome, which can cause skin burns, hair loss, nausea, vomiting, dizziness, disorientation, low blood pressure, headache, fatigue, weakness, fever, birth defects, illness, infection, and death. (1, 3)

Treatment

Treatment reversing the effects of irradiation is currently not possible. Anaesthetics and antiemetics are administered to counter the symptoms of exposure, as well as antibiotics for countering secondary infections due to the resulting immune system deficiency. (3)

Concentrations

Not Available

External Links

DrugBank ID

Not Available

HMDB ID

Not Available

FooDB ID

Not Available

Phenol Explorer ID

Not Available

KNApSAcK ID

Not Available

BiGG ID

Not Available

BioCyc ID

Not Available

METLIN ID

Not Available

PDB ID

Not Available

Wikipedia Link

Isotopes of neptunium

Chemspider ID

Not Available

ChEBI ID

Not Available

PubChem Compound ID

104783

Kegg Compound ID

Not Available

YMDB ID

Not Available

ECMDB ID

Not Available

References

Synthesis Reference

Not Available

MSDS

Not Available

General References

Not Available

Neptunium-237 (CHEM000126)

Structure for CHEM000126: Neptunium-237