141462 <common-name>Altinicline</common-name> <description>Altinicline is an organic compound with the formula C12H14N2 and an average molecular weight of 186.26 g/mol. Altinicline belongs to the pyrrolidinylpyridines, a subclass of pyridines and derivatives within the organic compounds. This organoheterocyclic compound acts as a modulator of two protein targets: the neuronal acetylcholine receptor subunit alpha-4 (CHRNA4) and the neuronal acetylcholine receptor subunit beta-2 (CHRNB2).</description> <cas>179120-92-4</cas> <pubchem-id>3036156</pubchem-id> <chemical-formula>C12H14N2</chemical-formula> <weight>186.25</weight> <appearance nil="true"/> <melting-point nil="true"/> <boiling-point nil="true"/> <density nil="true"/> <solubility nil="true"/> <specific-gravity nil="true"/> <flash-point nil="true"/> <vapour-pressure nil="true"/> <route-of-exposure nil="true"/> <target nil="true"/> <mechanism-of-toxicity nil="true"/> <metabolism nil="true"/> <toxicity nil="true"/> <lethaldose nil="true"/> <carcinogenicity nil="true"/> <use-source nil="true"/> <min-risk-level nil="true"/> <health-effects nil="true"/> <symptoms nil="true"/> <treatment nil="true"/> <created-at type="dateTime">2026-04-15T17:49:40Z</created-at> <updated-at type="dateTime">2026-08-18T17:40:30Z</updated-at> <interacting-proteins nil="true"/> <wikipedia nil="true"/> <uniprot-id nil="true"/> <kegg-compound-id nil="true"/> <omim-id nil="true"/> <chebi-id nil="true"/> <biocyc-id nil="true"/> <ctd-id nil="true"/> <stitch-id nil="true"/> <drugbank-id>DB21141</drugbank-id> <pdb-id nil="true"/> <actor-id nil="true"/> <organism nil="true"/> <export type="boolean">true</export> <metabolizing-proteins nil="true"/> <transporting-proteins nil="true"/> <moldb-smiles>CN1CCC[C@H]1C1=CC(=CN=C1)C#C</moldb-smiles> <moldb-formula>C12H14N2</moldb-formula> <moldb-inchi>InChI=1S/C12H14N2/c1-3-10-7-11(9-13-8-10)12-5-4-6-14(12)2/h1,7-9,12H,4-6H2,2H3/t12-/m0/s1</moldb-inchi> <moldb-inchikey>NUPUDYKEEJNZRG-LBPRGKRZSA-N</moldb-inchikey> <moldb-average-mass type="decimal">186.258</moldb-average-mass> <moldb-mono-mass type="decimal">186.115698459</moldb-mono-mass> <origin nil="true"/> <state nil="true"/> <logp>1.4</logp> <hmdb-id nil="true"/> <chembl-id nil="true"/> <chemspider-id nil="true"/> <structure-image-file-name nil="true"/> <structure-image-content-type nil="true"/> <structure-image-file-size type="integer" nil="true"/> <structure-image-updated-at type="dateTime" nil="true"/> <biodb-id nil="true"/> <synthesis-reference nil="true"/> <structure-image-caption nil="true"/> <chemdb-id>CHEM137355</chemdb-id> <dsstox-id nil="true"/> <toxcast-id nil="true"/> <stoff-ident-origin nil="true"/> <stoff-ident-id nil="true"/> <susdat-id nil="true"/> <iupac>3-ethynyl-5-[(2S)-1-methylpyrrolidin-2-yl]pyridine</iupac> <moldb-polar-surface-area nil="true"/> <moldb-refractivity nil="true"/> <moldb-polarizability nil="true"/> <moldb-rotatable-bond-count nil="true"/> <moldb-acceptor-count nil="true"/> <moldb-donor-count nil="true"/> <moldb-pka-strongest-acidic nil="true"/> <moldb-pka-strongest-basic nil="true"/> <moldb-physiological-charge nil="true"/> <moldb-number-of-rings nil="true"/> <moldb-alogps-logp nil="true"/> <moldb-alogps-logs nil="true"/> <moldb-alogps-solubility nil="true"/> <kingdom>Organic compounds</kingdom> <superklass>Organoheterocyclic compounds</superklass> <klass>Pyridines and derivatives</klass> <subklass>Pyrrolidinylpyridines</subklass> <paper-count type="integer">9</paper-count> <sync-id>CED0036501</sync-id> <structure-inchikey>NUPUDYKEEJNZRG-LBPRGKRZSA-N</structure-inchikey> <structure-fingerprint>2000000000200000000000000000000010000000000000000000000000000000000002400000000000000020000000002000000000000000000200000000000000000000000000020000000000000000004000000000000000000000000000000100000000010020100000000020000000000100800000040000000000080000000004000000400009000000000000000000001000000008004000000000000080080000000000000000000008000000000000100000000000000001000000400000000000000000000000000000000000000000000000000010000000040000000000000000000000000000000000000000000</structure-fingerprint> <structure-pattern-fingerprint>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</structure-pattern-fingerprint> <structure-pickle type="binary" encoding="base64">776t3gAAAAAQAAAAAwAAAAAAAAAOAAAADwAAAIABBgBgAAAAAQMHACAAAAAD BgBgAAAAAgIGAGAAAAACAgYAYAAAAAICBiA0AAAAAQEEBkAoAAAAAwQGQGgA AAADAwEGQCgAAAADBAZAaAAAAAMDAQdAKAAAAAMDBkBoAAAAAwMBBgAoAAAA AgQGAGgAAAACAwELAAEAAQIAAgMAAwQABAUABQYABgdoDAcIaAwICWgMCQpo DAoLaAwIDCAMDSgDBQEACwZoDEICAAAABQECAwQFBgcICQoLBhcEAAAAAAAA ABY= </structure-pickle> <structure-indexed-at type="dateTime">2026-09-19T04:52:12Z</structure-indexed-at> </compound>