138464 <common-name>AZD-5153</common-name> <description>AZD-5153 is an organic compound with the formula C25H33N7O3 and an average molecular weight of 479.58 g/mol. AZD-5153 belongs to the phenylpiperidines, a subclass of piperidines within the organic compounds. Classified as an organoheterocyclic compound, it functions as an inhibitor of Bromodomain-containing protein 4 (BRD4).</description> <cas>1869912-39-9</cas> <pubchem-id>118693659</pubchem-id> <chemical-formula>C25H33N7O3</chemical-formula> <weight>479.6</weight> <appearance nil="true"/> <melting-point nil="true"/> <boiling-point nil="true"/> <density nil="true"/> <solubility nil="true"/> <specific-gravity nil="true"/> <flash-point nil="true"/> <vapour-pressure nil="true"/> <route-of-exposure nil="true"/> <target nil="true"/> <mechanism-of-toxicity nil="true"/> <metabolism nil="true"/> <toxicity nil="true"/> <lethaldose nil="true"/> <carcinogenicity nil="true"/> <use-source nil="true"/> <min-risk-level nil="true"/> <health-effects nil="true"/> <symptoms nil="true"/> <treatment nil="true"/> <created-at type="dateTime">2026-04-14T21:09:51Z</created-at> <updated-at type="dateTime">2026-08-22T05:24:44Z</updated-at> <interacting-proteins nil="true"/> <wikipedia nil="true"/> <uniprot-id nil="true"/> <kegg-compound-id nil="true"/> <omim-id nil="true"/> <chebi-id nil="true"/> <biocyc-id nil="true"/> <ctd-id nil="true"/> <stitch-id nil="true"/> <drugbank-id>DB17018</drugbank-id> <pdb-id nil="true"/> <actor-id nil="true"/> <organism nil="true"/> <export type="boolean">true</export> <metabolizing-proteins nil="true"/> <transporting-proteins nil="true"/> <moldb-smiles>COC1=NN=C2C=CC(=NN12)N1CCC(CC1)C1=CC=C(OCCN2CCN(C)C(=O)[C@H]2C)C=C1</moldb-smiles> <moldb-formula>C25H33N7O3</moldb-formula> <moldb-inchi>InChI=1S/C25H33N7O3/c1-18-24(33)29(2)14-15-30(18)16-17-35-21-6-4-19(5-7-21)20-10-12-31(13-11-20)23-9-8-22-26-27-25(34-3)32(22)28-23/h4-9,18,20H,10-17H2,1-3H3/t18-/m1/s1</moldb-inchi> <moldb-inchikey>RSMYFSPOTCDHHJ-GOSISDBHSA-N</moldb-inchikey> <moldb-average-mass type="decimal">479.585</moldb-average-mass> <moldb-mono-mass type="decimal">479.264487951</moldb-mono-mass> <origin nil="true"/> <state nil="true"/> <logp>2.57</logp> <hmdb-id nil="true"/> <chembl-id nil="true"/> <chemspider-id nil="true"/> <structure-image-file-name nil="true"/> <structure-image-content-type nil="true"/> <structure-image-file-size type="integer" nil="true"/> <structure-image-updated-at type="dateTime" nil="true"/> <biodb-id nil="true"/> <synthesis-reference nil="true"/> <structure-image-caption nil="true"/> <chemdb-id>CHEM134357</chemdb-id> <dsstox-id nil="true"/> <toxcast-id nil="true"/> <stoff-ident-origin nil="true"/> <stoff-ident-id nil="true"/> <susdat-id nil="true"/> <iupac>(3R)-4-{2-[4-(1-{3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl}piperidin-4-yl)phenoxy]ethyl}-1,3-dimethylpiperazin-2-one</iupac> <moldb-polar-surface-area nil="true"/> <moldb-refractivity nil="true"/> <moldb-polarizability nil="true"/> <moldb-rotatable-bond-count nil="true"/> <moldb-acceptor-count nil="true"/> <moldb-donor-count nil="true"/> <moldb-pka-strongest-acidic nil="true"/> <moldb-pka-strongest-basic nil="true"/> <moldb-physiological-charge nil="true"/> <moldb-number-of-rings nil="true"/> <moldb-alogps-logp nil="true"/> <moldb-alogps-logs nil="true"/> <moldb-alogps-solubility nil="true"/> <kingdom>Organic compounds</kingdom> <superklass>Organoheterocyclic compounds</superklass> <klass>Piperidines</klass> <subklass>Phenylpiperidines</subklass> <paper-count type="integer">395</paper-count> <sync-id>CED0012109</sync-id> <structure-inchikey>RSMYFSPOTCDHHJ-GOSISDBHSA-N</structure-inchikey> <structure-fingerprint>4040000000000000000800002000000020000008000000000200000000000000000000000040020201100000000002000010108000000008000000000000000000100008000000000000000004000100020000000000100000200000000000000000004200010000048000000020200000000020100000000000080000000100020000040000000000000000000004002080100800000000000000000004001000000040004000000000000080000000000000000080000008000000000000080000000000000000000000000000000000000040000000000000200000000800010000000800000200040020000000000000000080000000000800002000000</structure-fingerprint> <structure-pattern-fingerprint>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</structure-pattern-fingerprint> <structure-pickle type="binary" encoding="base64">776t3gAAAAAQAAAAAwAAAAAAAAAjAAAAJwAAAIABBgBgAAAAAQMIACgAAAAD AgZAKAAAAAMEB0AoAAAAAwMHQCgAAAADAwZAKAAAAAMEBkBoAAAAAwMBBkBo AAAAAwMBBkAoAAAAAwQHQCgAAAADAwdAKAAAAAMDBwAoAAAAAwMGAGAAAAAC AgYAYAAAAAICBgBgAAAAAwEGAGAAAAACAgYAYAAAAAICBkAoAAAAAwQGQGgA AAADAwEGQGgAAAADAwEGQCgAAAADBAgAKAAAAAMCBgBgAAAAAgIGAGAAAAAC AgcAIAAAAAMGAGAAAAACAgYAYAAAAAICBwAoAAAAAwMGAGAAAAABAwYAKAAA AAMECAAoAAAAAwIGIDQAAAABAQQGAGAAAAABAwZAaAAAAAMDAQZAaAAAAAMD AQsAAQABAiACA2gMAwRoDAQFaAwFBmgMBgdoDAcIaAwICWgMCQpoDAgLIAsM AAwNAA0OAA4PAA8QAA4RABESaAwSE2gMExRoDBQVIBUWABYXABcYABgZABka ABobABscABsdIB0eKAIdHwAfIAAUIWgMISJoDAoCaAwQCwAiEWgMCgVoDB8Y AEIFAAAABQIDBAUKBgYHCAkKBQYMDQ4PEAsGEhMUISIRBhkaGx0fGBcEAAAA AAAAABY= </structure-pickle> <structure-indexed-at type="dateTime">2026-09-19T04:50:46Z</structure-indexed-at> </compound>