138367 <common-name>AF-710B</common-name> <description>AF-710B is an organic compound with the formula C20H27N3OS and an average molecular weight of 357.52 g/mol. AF-710B belongs to the tryptamines and derivatives, a subclass of indoles and derivatives within the organic compounds. Within the superclass of organoheterocyclic compounds, this substance is recorded as having two protein targets. It acts as an agonist of the Sigma non-opioid intracellular receptor 1 (SIGMAR1) and the Muscarinic acetylcholine receptor M1 (CHRM1).</description> <cas>1235733-73-9</cas> <pubchem-id nil="true"/> <chemical-formula>C20H27N3OS</chemical-formula> <weight nil="true"/> <appearance nil="true"/> <melting-point nil="true"/> <boiling-point nil="true"/> <density nil="true"/> <solubility nil="true"/> <specific-gravity nil="true"/> <flash-point nil="true"/> <vapour-pressure nil="true"/> <route-of-exposure nil="true"/> <target nil="true"/> <mechanism-of-toxicity nil="true"/> <metabolism nil="true"/> <toxicity nil="true"/> <lethaldose nil="true"/> <carcinogenicity nil="true"/> <use-source nil="true"/> <min-risk-level nil="true"/> <health-effects nil="true"/> <symptoms nil="true"/> <treatment nil="true"/> <created-at type="dateTime">2026-04-14T21:06:38Z</created-at> <updated-at type="dateTime">2026-05-14T20:00:26Z</updated-at> <interacting-proteins nil="true"/> <wikipedia nil="true"/> <uniprot-id nil="true"/> <kegg-compound-id nil="true"/> <omim-id nil="true"/> <chebi-id nil="true"/> <biocyc-id nil="true"/> <ctd-id nil="true"/> <stitch-id nil="true"/> <drugbank-id>DB16911</drugbank-id> <pdb-id nil="true"/> <actor-id nil="true"/> <organism nil="true"/> <export type="boolean">true</export> <metabolizing-proteins nil="true"/> <transporting-proteins nil="true"/> <moldb-smiles>CC1SC2(CN1C(=O)CCC1=CNC3=C1C=CC=C3)CCN(C)CC2</moldb-smiles> <moldb-formula>C20H27N3OS</moldb-formula> <moldb-inchi>InChI=1S/C20H27N3OS/c1-15-23(14-20(25-15)9-11-22(2)12-10-20)19(24)8-7-16-13-21-18-6-4-3-5-17(16)18/h3-6,13,15,21H,7-12,14H2,1-2H3</moldb-inchi> <moldb-inchikey>XWMHYQATSBWUNT-UHFFFAOYSA-N</moldb-inchikey> <moldb-average-mass type="decimal">357.52</moldb-average-mass> <moldb-mono-mass type="decimal">357.187483675</moldb-mono-mass> <origin nil="true"/> <state nil="true"/> <logp>2.27</logp> <hmdb-id nil="true"/> <chembl-id nil="true"/> <chemspider-id nil="true"/> <structure-image-file-name nil="true"/> <structure-image-content-type nil="true"/> <structure-image-file-size type="integer" nil="true"/> <structure-image-updated-at type="dateTime" nil="true"/> <biodb-id nil="true"/> <synthesis-reference nil="true"/> <structure-image-caption nil="true"/> <chemdb-id>CHEM134260</chemdb-id> <dsstox-id nil="true"/> <toxcast-id nil="true"/> <stoff-ident-origin nil="true"/> <stoff-ident-id nil="true"/> <susdat-id nil="true"/> <iupac>1-{2,8-dimethyl-1-thia-3,8-diazaspiro[4.5]decan-3-yl}-3-(1H-indol-3-yl)propan-1-one</iupac> <moldb-polar-surface-area nil="true"/> <moldb-refractivity nil="true"/> <moldb-polarizability nil="true"/> <moldb-rotatable-bond-count nil="true"/> <moldb-acceptor-count nil="true"/> <moldb-donor-count nil="true"/> <moldb-pka-strongest-acidic nil="true"/> <moldb-pka-strongest-basic nil="true"/> <moldb-physiological-charge nil="true"/> <moldb-number-of-rings nil="true"/> <moldb-alogps-logp nil="true"/> <moldb-alogps-logs nil="true"/> <moldb-alogps-solubility nil="true"/> <kingdom>Organic compounds</kingdom> <superklass>Organoheterocyclic compounds</superklass> <klass>Indoles and derivatives</klass> <subklass>Tryptamines and derivatives</subklass> <paper-count type="integer">1</paper-count> <sync-id>CED0063818</sync-id> <structure-inchikey>XWMHYQATSBWUNT-UHFFFAOYSA-N</structure-inchikey> <structure-fingerprint>10000000000000000800000000100000000000000000000010000000020000000000000000000008000000008000000000000000000008000000800000000000000000000004000000020000000000020000010000000000000000000400000000080030000000000000000000000000000020100000008000000000040100000000048000000800000200000004000200000000100000004081000000000000000040000000004040000080000080000000000000000008000000000002000000008040000000100000010000000000000000000010000000200000001000000000000000000000041000000000400004000000000000000000000012000</structure-fingerprint> 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