138169 <common-name>Izencitinib</common-name> <description>Izencitinib belongs to the naphthyridines, a subclass of diazanaphthalenes within the organic compounds. It is an organoheterocyclic compound with the formula C22H26N8 and an average molecular weight of 402.51 g/mol.</description> <cas>2051918-33-1</cas> <pubchem-id nil="true"/> <chemical-formula>C22H26N8</chemical-formula> <weight nil="true"/> <appearance nil="true"/> <melting-point nil="true"/> <boiling-point nil="true"/> <density nil="true"/> <solubility nil="true"/> <specific-gravity nil="true"/> <flash-point nil="true"/> <vapour-pressure nil="true"/> <route-of-exposure nil="true"/> <target nil="true"/> <mechanism-of-toxicity nil="true"/> <metabolism nil="true"/> <toxicity nil="true"/> <lethaldose nil="true"/> <carcinogenicity nil="true"/> <use-source nil="true"/> <min-risk-level nil="true"/> <health-effects nil="true"/> <symptoms nil="true"/> <treatment nil="true"/> <created-at type="dateTime">2026-04-14T20:59:13Z</created-at> <updated-at type="dateTime">2026-05-14T19:58:53Z</updated-at> <interacting-proteins nil="true"/> <wikipedia nil="true"/> <uniprot-id nil="true"/> <kegg-compound-id nil="true"/> <omim-id nil="true"/> <chebi-id nil="true"/> <biocyc-id nil="true"/> <ctd-id nil="true"/> <stitch-id nil="true"/> <drugbank-id>DB16660</drugbank-id> <pdb-id nil="true"/> <actor-id nil="true"/> <organism nil="true"/> <export type="boolean">true</export> <metabolizing-proteins nil="true"/> <transporting-proteins nil="true"/> <moldb-smiles>CC1=CC(NC2=NC(N[C@H]3C[C@@H]4CC[C@H](C3)N4CCC#N)=C3C=CC=NC3=C2)=NN1</moldb-smiles> <moldb-formula>C22H26N8</moldb-formula> <moldb-inchi>InChI=1S/C22H26N8/c1-14-10-21(29-28-14)26-20-13-19-18(4-2-8-24-19)22(27-20)25-15-11-16-5-6-17(12-15)30(16)9-3-7-23/h2,4,8,10,13,15-17H,3,5-6,9,11-12H2,1H3,(H3,25,26,27,28,29)/t15-,16-,17+</moldb-inchi> <moldb-inchikey>DADAEARVGOQWHV-OSYLJGHBSA-N</moldb-inchikey> <moldb-average-mass type="decimal">402.506</moldb-average-mass> <moldb-mono-mass type="decimal">402.228042869</moldb-mono-mass> <origin nil="true"/> <state nil="true"/> <logp>2.44</logp> <hmdb-id nil="true"/> <chembl-id nil="true"/> <chemspider-id nil="true"/> <structure-image-file-name nil="true"/> <structure-image-content-type nil="true"/> <structure-image-file-size type="integer" nil="true"/> <structure-image-updated-at type="dateTime" nil="true"/> <biodb-id nil="true"/> <synthesis-reference nil="true"/> <structure-image-caption nil="true"/> <chemdb-id>CHEM134062</chemdb-id> <dsstox-id nil="true"/> <toxcast-id nil="true"/> <stoff-ident-origin nil="true"/> <stoff-ident-id nil="true"/> <susdat-id nil="true"/> <iupac>3-[(1R,3S,5S)-3-({7-[(5-methyl-1H-pyrazol-3-yl)amino]-1,6-naphthyridin-5-yl}amino)-8-azabicyclo[3.2.1]octan-8-yl]propanenitrile</iupac> <moldb-polar-surface-area nil="true"/> <moldb-refractivity nil="true"/> <moldb-polarizability nil="true"/> <moldb-rotatable-bond-count nil="true"/> <moldb-acceptor-count nil="true"/> <moldb-donor-count nil="true"/> <moldb-pka-strongest-acidic nil="true"/> <moldb-pka-strongest-basic nil="true"/> <moldb-physiological-charge nil="true"/> <moldb-number-of-rings nil="true"/> <moldb-alogps-logp nil="true"/> <moldb-alogps-logs nil="true"/> <moldb-alogps-solubility nil="true"/> <kingdom>Organic compounds</kingdom> <superklass>Organoheterocyclic compounds</superklass> <klass>Diazanaphthalenes</klass> <subklass>Naphthyridines</subklass> <paper-count type="integer">42</paper-count> <sync-id>CED0024588</sync-id> <structure-inchikey>DADAEARVGOQWHV-OSYLJGHBSA-N</structure-inchikey> <structure-fingerprint>20800000000000000000000000000000000000000008000008000000000010000020000000002000000004000800008000100000100000000000000000000000000000000040000000000060000800084000000000000000000200000000500000000000100008000000020100000000010000000000500080100040000000c25000200000004080080000010000000080800000000000000800000004000000040000088000000000000000080000000000000000000000000000040004000000000024000000000000000000002000000200000000000040000000000001002040000000020010000000000000000000080000000000</structure-fingerprint> 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