137065 <common-name>Inavolisib</common-name> <description>Inavolisib is an organic compound with the formula C18H19F2N5O4 and an average molecular weight of 407.38 g/mol. Inavolisib belongs to the amines, a subclass of organonitrogen compounds within the organic compounds. This compound acts on two recorded protein targets, serving as an inhibitor or degradation agent of the phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) and the phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG).</description> <cas>2060571-02-8</cas> <pubchem-id>124173720</pubchem-id> <chemical-formula>C18H19F2N5O4</chemical-formula> <weight>407.4</weight> <appearance nil="true"/> <melting-point nil="true"/> <boiling-point nil="true"/> <density nil="true"/> <solubility nil="true"/> <specific-gravity nil="true"/> <flash-point nil="true"/> <vapour-pressure nil="true"/> <route-of-exposure nil="true"/> <target nil="true"/> <mechanism-of-toxicity nil="true"/> <metabolism nil="true"/> <toxicity nil="true"/> <lethaldose nil="true"/> <carcinogenicity nil="true"/> <use-source nil="true"/> <min-risk-level nil="true"/> <health-effects nil="true"/> <symptoms nil="true"/> <treatment nil="true"/> <created-at type="dateTime">2026-04-14T20:12:27Z</created-at> <updated-at type="dateTime">2026-08-20T00:07:15Z</updated-at> <interacting-proteins nil="true"/> <wikipedia nil="true"/> <uniprot-id nil="true"/> <kegg-compound-id nil="true"/> <omim-id nil="true"/> <chebi-id nil="true"/> <biocyc-id nil="true"/> <ctd-id nil="true"/> <stitch-id nil="true"/> <drugbank-id>DB15275</drugbank-id> <pdb-id nil="true"/> <actor-id nil="true"/> <organism nil="true"/> <export type="boolean">true</export> <metabolizing-proteins nil="true"/> <transporting-proteins nil="true"/> <moldb-smiles>C[C@H](NC1=CC=C2C3=NC(=CN3CCOC2=C1)N1[C@@H](COC1=O)C(F)F)C(N)=O</moldb-smiles> <moldb-formula>C18H19F2N5O4</moldb-formula> <moldb-inchi>InChI=1S/C18H19F2N5O4/c1-9(16(21)26)22-10-2-3-11-13(6-10)28-5-4-24-7-14(23-17(11)24)25-12(15(19)20)8-29-18(25)27/h2-3,6-7,9,12,15,22H,4-5,8H2,1H3,(H2,21,26)/t9-,12-/m0/s1</moldb-inchi> <moldb-inchikey>SGEUNORSOZVTOL-CABZTGNLSA-N</moldb-inchikey> <moldb-average-mass type="decimal">407.378</moldb-average-mass> <moldb-mono-mass type="decimal">407.140510438</moldb-mono-mass> <origin nil="true"/> <state nil="true"/> <logp>1.16</logp> <hmdb-id nil="true"/> <chembl-id nil="true"/> <chemspider-id nil="true"/> <structure-image-file-name nil="true"/> <structure-image-content-type nil="true"/> <structure-image-file-size type="integer" nil="true"/> <structure-image-updated-at type="dateTime" nil="true"/> <biodb-id nil="true"/> <synthesis-reference nil="true"/> <structure-image-caption nil="true"/> <chemdb-id>CHEM132958</chemdb-id> <dsstox-id nil="true"/> <toxcast-id nil="true"/> <stoff-ident-origin nil="true"/> <stoff-ident-id nil="true"/> <susdat-id nil="true"/> <iupac>(2S)-2-({4-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-9-oxa-3,6-diazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),2,4,10,12-pentaen-12-yl}amino)propanamide</iupac> <moldb-polar-surface-area nil="true"/> <moldb-refractivity nil="true"/> <moldb-polarizability nil="true"/> <moldb-rotatable-bond-count nil="true"/> <moldb-acceptor-count nil="true"/> <moldb-donor-count nil="true"/> <moldb-pka-strongest-acidic nil="true"/> <moldb-pka-strongest-basic nil="true"/> <moldb-physiological-charge nil="true"/> <moldb-number-of-rings nil="true"/> <moldb-alogps-logp nil="true"/> <moldb-alogps-logs nil="true"/> <moldb-alogps-solubility nil="true"/> <kingdom>Organic compounds</kingdom> <superklass>Organic nitrogen compounds</superklass> <klass>Organonitrogen compounds</klass> <subklass>Amines</subklass> <paper-count type="integer">592</paper-count> <sync-id>CED0010438</sync-id> <structure-inchikey>SGEUNORSOZVTOL-CABZTGNLSA-N</structure-inchikey> <structure-fingerprint>4000000004100000000000000000000100080000000020010000000000000000000000100000002000000000800000201000000400000040000080000000000000010000200000000400000080000000002080000080200000000000000000000000000201000000001000000210000000002002010002000000000c000000100000002040000000000000000200000080001000000000080000000090100000000000000000000000002000080000000040040000000000008000000000004000000000000000000000000000000008000020000000002000000200000000000000000000000001000040000000400430800000000000000000200000000000</structure-fingerprint> <structure-pattern-fingerprint>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</structure-pattern-fingerprint> <structure-pickle>ï¾­Þ�������������������� ���€���`������ 4��������h�������@(������@h�������@h�������@(������@(������@(������@(������@h�������@(�������`�������`�������(������@(������@h��������(������ 4��������`�������(�������(�������(�������`����� � ���� � ������(�������h��������(�������������� ��h���h���h��� ��h�� h� h� �h����� � ���� ��h� � ����������� ��(��������������� ��(���h��� ��h���h�B��������������� ������� ����������������</structure-pickle> <structure-indexed-at type="dateTime">2026-09-19T04:50:16Z</structure-indexed-at> </compound>