137046 <common-name>Avutometinib</common-name> <description>Avutometinib is an organic compound with the chemical formula C21H18FN5O5S and an average molecular weight of 471.46 g/mol. Avutometinib belongs to the coumarins and derivatives, a class of phenylpropanoids and polyketides within the organic compounds. In terms of biological activity, the compound acts upon six recorded protein targets. It functions as an inhibitor and modulator of Serine/threonine-protein kinase A-Raf (ARAF), Serine/threonine-protein kinase B-raf (BRAF), and RAF proto-oncogene serine/threonine-protein kinase (RAF1). Additionally, it acts as an inhibitor and modulator of Microtubule-associated protein 1A (MAP1A) and two other proteins.</description> <cas>946128-88-7</cas> <pubchem-id>16719221</pubchem-id> <chemical-formula>C21H18FN5O5S</chemical-formula> <weight>471.5</weight> <appearance nil="true"/> <melting-point nil="true"/> <boiling-point nil="true"/> <density nil="true"/> <solubility nil="true"/> <specific-gravity nil="true"/> <flash-point nil="true"/> <vapour-pressure nil="true"/> <route-of-exposure nil="true"/> <target nil="true"/> <mechanism-of-toxicity nil="true"/> <metabolism nil="true"/> <toxicity nil="true"/> <lethaldose nil="true"/> <carcinogenicity nil="true"/> <use-source nil="true"/> <min-risk-level nil="true"/> <health-effects nil="true"/> <symptoms nil="true"/> <treatment nil="true"/> <created-at type="dateTime">2026-04-14T20:11:48Z</created-at> <updated-at type="dateTime">2026-08-21T18:04:20Z</updated-at> <interacting-proteins nil="true"/> <wikipedia nil="true"/> <uniprot-id nil="true"/> <kegg-compound-id nil="true"/> <omim-id nil="true"/> <chebi-id nil="true"/> <biocyc-id nil="true"/> <ctd-id nil="true"/> <stitch-id nil="true"/> <drugbank-id>DB15254</drugbank-id> <pdb-id nil="true"/> <actor-id nil="true"/> <organism nil="true"/> <export type="boolean">true</export> <metabolizing-proteins nil="true"/> <transporting-proteins nil="true"/> <moldb-smiles>CNS(=O)(=O)NC1=C(F)C(CC2=C(C)C3=C(OC2=O)C=C(OC2=NC=CC=N2)C=C3)=CC=N1</moldb-smiles> <moldb-formula>C21H18FN5O5S</moldb-formula> <moldb-inchi>InChI=1S/C21H18FN5O5S/c1-12-15-5-4-14(31-21-25-7-3-8-26-21)11-17(15)32-20(28)16(12)10-13-6-9-24-19(18(13)22)27-33(29,30)23-2/h3-9,11,23H,10H2,1-2H3,(H,24,27)</moldb-inchi> <moldb-inchikey>LMMJFBMMJUMSJS-UHFFFAOYSA-N</moldb-inchikey> <moldb-average-mass type="decimal">471.46</moldb-average-mass> <moldb-mono-mass type="decimal">471.101268037</moldb-mono-mass> <origin nil="true"/> <state nil="true"/> <logp>1.97</logp> <hmdb-id nil="true"/> <chembl-id nil="true"/> <chemspider-id nil="true"/> <structure-image-file-name nil="true"/> <structure-image-content-type nil="true"/> <structure-image-file-size type="integer" nil="true"/> <structure-image-updated-at type="dateTime" nil="true"/> <biodb-id nil="true"/> <synthesis-reference nil="true"/> <structure-image-caption nil="true"/> <chemdb-id>CHEM132939</chemdb-id> <dsstox-id nil="true"/> <toxcast-id nil="true"/> <stoff-ident-origin nil="true"/> <stoff-ident-id nil="true"/> <susdat-id nil="true"/> <iupac>3-({3-fluoro-2-[(methylsulfamoyl)amino]pyridin-4-yl}methyl)-4-methyl-7-(pyrimidin-2-yloxy)-2H-chromen-2-one</iupac> <moldb-polar-surface-area nil="true"/> <moldb-refractivity nil="true"/> <moldb-polarizability nil="true"/> <moldb-rotatable-bond-count nil="true"/> <moldb-acceptor-count nil="true"/> <moldb-donor-count nil="true"/> <moldb-pka-strongest-acidic nil="true"/> <moldb-pka-strongest-basic nil="true"/> <moldb-physiological-charge nil="true"/> <moldb-number-of-rings nil="true"/> <moldb-alogps-logp nil="true"/> <moldb-alogps-logs nil="true"/> <moldb-alogps-solubility nil="true"/> <kingdom>Organic compounds</kingdom> <superklass>Phenylpropanoids and polyketides</superklass> <klass>Coumarins and derivatives</klass> <subklass nil="true"/> <paper-count type="integer">464</paper-count> <sync-id>CED0011408</sync-id> <structure-inchikey>LMMJFBMMJUMSJS-UHFFFAOYSA-N</structure-inchikey> <structure-fingerprint>800000000000802000040000000800000000000000080000000000004020200000020000002000000200000000008020000000000000000000000000048000010000000000000020800000000110080200000000000000001000000000000000000000100000000000000000000000000000000000000000000040000000800000000000000080010000000000000000010000000200000000000000000004040020080000010100020004080008080000000008000000000000004000000800400000000400000000000000002004000200000000000010800200000000002040000000000000800000000008000000000000002800</structure-fingerprint> <structure-pattern-fingerprint>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</structure-pattern-fingerprint> <structure-pickle>ï¾­Þ����������������!���$���€���`�������`������� ������(�������(�������h�������@(������@(����� � �����@(�������`������@(������@(�������`������@(������@(������@(������@(�������(������@h�������@(�������(������@(������@(������@h�������@h�������@h�������@(������@h�������@h�������@h�������@h�������@(������������������������� ��h����� h� � ����h�� ���h���h���h���h���(���h���h��� �� ��h���h���h���h���h���h���h� �h���h�� h� �h���h���h���h�B������ �� ��������������������������������</structure-pickle> <structure-indexed-at type="dateTime">2026-09-19T04:50:16Z</structure-indexed-at> </compound>