136992 <common-name>ABT-288</common-name> <description>ABT-288 is an organic compound with the chemical formula C23H24N4O and an average molecular weight of 372.47 g/mol. ABT-288 belongs to the biphenyls and derivatives, a subclass of benzene and substituted derivatives within the organic compounds. It is further classified within the superclass of benzenoids. Regarding its biological activity, one protein target has been recorded for this compound, identifying it as a modulator of the Histamine H3 receptor (HRH3).</description> <cas>948845-91-8</cas> <pubchem-id>24743471</pubchem-id> <chemical-formula>C23H24N4O</chemical-formula> <weight>372.5</weight> <appearance nil="true"/> <melting-point nil="true"/> <boiling-point nil="true"/> <density nil="true"/> <solubility nil="true"/> <specific-gravity nil="true"/> <flash-point nil="true"/> <vapour-pressure nil="true"/> <route-of-exposure nil="true"/> <target nil="true"/> <mechanism-of-toxicity nil="true"/> <metabolism nil="true"/> <toxicity nil="true"/> <lethaldose nil="true"/> <carcinogenicity nil="true"/> <use-source nil="true"/> <min-risk-level nil="true"/> <health-effects nil="true"/> <symptoms nil="true"/> <treatment nil="true"/> <created-at type="dateTime">2026-04-14T20:09:35Z</created-at> <updated-at type="dateTime">2026-08-22T00:18:47Z</updated-at> <interacting-proteins nil="true"/> <wikipedia nil="true"/> <uniprot-id nil="true"/> <kegg-compound-id nil="true"/> <omim-id nil="true"/> <chebi-id nil="true"/> <biocyc-id nil="true"/> <ctd-id nil="true"/> <stitch-id nil="true"/> <drugbank-id>DB15192</drugbank-id> <pdb-id nil="true"/> <actor-id nil="true"/> <organism nil="true"/> <export type="boolean">true</export> <metabolizing-proteins nil="true"/> <transporting-proteins nil="true"/> <moldb-smiles>CN1C[C@H]2CCN([C@H]2C1)C1=CC=C(C=C1)C1=CC=C(C=C1)N1N=CC=CC1=O</moldb-smiles> <moldb-formula>C23H24N4O</moldb-formula> <moldb-inchi>InChI=1S/C23H24N4O/c1-25-15-19-12-14-26(22(19)16-25)20-8-4-17(5-9-20)18-6-10-21(11-7-18)27-23(28)3-2-13-24-27/h2-11,13,19,22H,12,14-16H2,1H3/t19-,22+/m1/s1</moldb-inchi> <moldb-inchikey>GNIRITULTPTAQW-KNQAVFIVSA-N</moldb-inchikey> <moldb-average-mass type="decimal">372.472</moldb-average-mass> <moldb-mono-mass type="decimal">372.195011409</moldb-mono-mass> <origin nil="true"/> <state nil="true"/> <logp>3.06</logp> <hmdb-id nil="true"/> <chembl-id nil="true"/> <chemspider-id nil="true"/> <structure-image-file-name nil="true"/> <structure-image-content-type nil="true"/> <structure-image-file-size type="integer" nil="true"/> <structure-image-updated-at type="dateTime" nil="true"/> <biodb-id nil="true"/> <synthesis-reference nil="true"/> <structure-image-caption nil="true"/> <chemdb-id>CHEM132885</chemdb-id> <dsstox-id nil="true"/> <toxcast-id nil="true"/> <stoff-ident-origin nil="true"/> <stoff-ident-id nil="true"/> <susdat-id nil="true"/> <iupac>2-{4'-[(3aR,6aR)-5-methyl-octahydropyrrolo[3,4-b]pyrrol-1-yl]-[1,1'-biphenyl]-4-yl}-2,3-dihydropyridazin-3-one</iupac> <moldb-polar-surface-area nil="true"/> <moldb-refractivity nil="true"/> <moldb-polarizability nil="true"/> <moldb-rotatable-bond-count nil="true"/> <moldb-acceptor-count nil="true"/> <moldb-donor-count nil="true"/> <moldb-pka-strongest-acidic nil="true"/> <moldb-pka-strongest-basic nil="true"/> <moldb-physiological-charge nil="true"/> <moldb-number-of-rings nil="true"/> <moldb-alogps-logp nil="true"/> <moldb-alogps-logs nil="true"/> <moldb-alogps-solubility nil="true"/> <kingdom>Organic compounds</kingdom> <superklass>Benzenoids</superklass> <klass>Benzene and substituted derivatives</klass> <subklass>Biphenyls and derivatives</subklass> <paper-count type="integer">71</paper-count> <sync-id>CED0021169</sync-id> <structure-inchikey>GNIRITULTPTAQW-KNQAVFIVSA-N</structure-inchikey> <structure-fingerprint>100000000400000000000000000000000000010001000000440000000000000000002000000000000000200100000000000000000000000000000000000000000000000040000000000000002000000008000000040020100000000000000000100000000000000000002080000002010000000000000000000010000010004000000080000000000004c000800000000000000000000000000000000000000004000000000020080000000000000480000000008000400000000000000000000000000000000000000000000000400000000000000200000000000000000040000008002040000020000080000000000800000000000000000000</structure-fingerprint> 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