135684 <common-name>Gemigliptin</common-name> <description>Gemigliptin is an organic compound with the chemical formula C18H19F8N5O2 and an average molecular weight of 489.37 g/mol. Gemigliptin belongs to the amino acids, peptides, and analogues, a subclass of carboxylic acids and derivatives within the organic compounds. Regarding its biological activity, the compound acts as an inhibitor of the protein target Dipeptidyl peptidase 4 (DPP4).</description> <cas>911637-19-9</cas> <pubchem-id>11953153</pubchem-id> <chemical-formula>C18H19F8N5O2</chemical-formula> <weight>489.4</weight> <appearance nil="true"/> <melting-point nil="true"/> <boiling-point nil="true"/> <density nil="true"/> <solubility nil="true"/> <specific-gravity nil="true"/> <flash-point nil="true"/> <vapour-pressure nil="true"/> <route-of-exposure nil="true"/> <target nil="true"/> <mechanism-of-toxicity nil="true"/> <metabolism nil="true"/> <toxicity nil="true"/> <lethaldose nil="true"/> <carcinogenicity nil="true"/> <use-source nil="true"/> <min-risk-level nil="true"/> <health-effects nil="true"/> <symptoms nil="true"/> <treatment nil="true"/> <created-at type="dateTime">2026-04-14T18:46:47Z</created-at> <updated-at type="dateTime">2026-08-20T00:07:32Z</updated-at> <interacting-proteins nil="true"/> <wikipedia nil="true"/> <uniprot-id nil="true"/> <kegg-compound-id nil="true"/> <omim-id nil="true"/> <chebi-id nil="true"/> <biocyc-id nil="true"/> <ctd-id nil="true"/> <stitch-id nil="true"/> <drugbank-id>DB12412</drugbank-id> <pdb-id nil="true"/> <actor-id nil="true"/> <organism nil="true"/> <export type="boolean">true</export> <metabolizing-proteins nil="true"/> <transporting-proteins nil="true"/> <moldb-smiles>N[C@H](CN1CC(F)(F)CCC1=O)CC(=O)N1CCC2=C(C1)N=C(N=C2C(F)(F)F)C(F)(F)F</moldb-smiles> <moldb-formula>C18H19F8N5O2</moldb-formula> <moldb-inchi>InChI=1S/C18H19F8N5O2/c19-16(20)3-1-12(32)31(8-16)6-9(27)5-13(33)30-4-2-10-11(7-30)28-15(18(24,25)26)29-14(10)17(21,22)23/h9H,1-8,27H2/t9-/m0/s1</moldb-inchi> <moldb-inchikey>ZWPRRQZNBDYKLH-VIFPVBQESA-N</moldb-inchikey> <moldb-average-mass type="decimal">489.37</moldb-average-mass> <moldb-mono-mass type="decimal">489.141100176</moldb-mono-mass> <origin nil="true"/> <state nil="true"/> <logp>1.72</logp> <hmdb-id nil="true"/> <chembl-id nil="true"/> <chemspider-id nil="true"/> <structure-image-file-name nil="true"/> <structure-image-content-type nil="true"/> <structure-image-file-size type="integer" nil="true"/> <structure-image-updated-at type="dateTime" nil="true"/> <biodb-id nil="true"/> <synthesis-reference nil="true"/> <structure-image-caption nil="true"/> <chemdb-id>CHEM131577</chemdb-id> <dsstox-id nil="true"/> <toxcast-id nil="true"/> <stoff-ident-origin nil="true"/> <stoff-ident-id nil="true"/> <susdat-id nil="true"/> <iupac>1-[(2S)-2-amino-4-[2,4-bis(trifluoromethyl)-5H,6H,7H,8H-pyrido[3,4-d]pyrimidin-7-yl]-4-oxobutyl]-5,5-difluoropiperidin-2-one</iupac> <moldb-polar-surface-area nil="true"/> <moldb-refractivity nil="true"/> <moldb-polarizability nil="true"/> <moldb-rotatable-bond-count nil="true"/> <moldb-acceptor-count nil="true"/> <moldb-donor-count nil="true"/> <moldb-pka-strongest-acidic nil="true"/> <moldb-pka-strongest-basic nil="true"/> <moldb-physiological-charge nil="true"/> <moldb-number-of-rings nil="true"/> <moldb-alogps-logp nil="true"/> <moldb-alogps-logs nil="true"/> <moldb-alogps-solubility nil="true"/> <kingdom>Organic compounds</kingdom> <superklass>Organic acids and derivatives</superklass> <klass>Carboxylic acids and derivatives</klass> <subklass>Amino acids, peptides, and analogues</subklass> <paper-count type="integer">695</paper-count> <sync-id>CED0009839</sync-id> <structure-inchikey>ZWPRRQZNBDYKLH-VIFPVBQESA-N</structure-inchikey> <structure-fingerprint>40000000000000000000900000002020000004000000010100000008000000100000001000000020000000000040002000000000000000000000000000000000000000000400041000000020000000000020000800000000000000000000000000002002014000000000000010000000000000020100000000000000000050000000000008000000400000000000100000201000800000002000000000000000002000000000008000000000080000000000000000040001008000100040000000000000000000000000200000000000000000000000000000200000008000000000000000010001000000000000000420800128000000000600004000000000</structure-fingerprint> <structure-pattern-fingerprint>7094c2008532864081029b6081b8a2009880140281052010803d20438224484e7c320051138000000100410800c0200084600225c08d3261032e653980a04210c7990c801281140044901140137202820804c59053211e374004456260225a058e2847af184c022040080488dd94064d348694720509c10631182f4102510002124011184ef1820828061250482c0088393d881244401e8a5420082460c0068400d3109200b0ca200b044968056c75100ac070028943084010904a980cc00232a01010a404980a331d808684545152910d0100100b6078010d60020128088300903549141881912411440411511220820052043090c2042e1300908852100206</structure-pattern-fingerprint> <structure-pickle type="binary" encoding="base64">776t3gAAAAAQAAAAAwAAAAAAAAAhAAAAIwAAAIABBwBgAAAAAQIGIDQAAAAC AQQGAGAAAAACAgcAKAAAAAMDBgBgAAAAAgIGACAAAAAECQAgAAAAAQkAIAAA AAEGAGAAAAACAgYAYAAAAAICBgAoAAAAAwQIACgAAAADAgYAYAAAAAICBgAo AAAAAwQIACgAAAADAgcAKAAAAAMDBgBgAAAAAgIGAGAAAAACAgZAKAAAAAME BkAoAAAAAwQGAGAAAAACAgdAKAAAAAMDBkAoAAAAAwQHQCgAAAADAwZAKAAA AAMEBgAgAAAABAkAIAAAAAEJACAAAAABCQAgAAAAAQYAIAAAAAQJACAAAAAB CQAgAAAAAQkAIAAAAAELAAEAAQIAAgMAAwQABAUABQYABQcABQgACAkACQoA CgsoAgEMAAwNAA0OKAINDyAPEAAQEQAREgASE2gMExQAExVoDBUWaAwWF2gM FxhoDBgZABkaABkbABkcABYdAB0eAB0fAB0gAAoDIBQPABgSaAxCAwAAAAYE BQgJCgMGEBESExQPBhUWFxgSExcEAAAAAAAAABY= </structure-pickle> <structure-indexed-at type="dateTime">2026-09-19T04:49:40Z</structure-indexed-at> </compound>