134343 <common-name>A-674563</common-name> <description>A-674563 is an organic compound with the formula C22H22N4O and an average molecular weight of 358.44 g/mol. A-674563 belongs to the phenethylamines, a subclass of benzene and substituted derivatives within the organic compounds. This compound is further classified as a member of the benzenoids superclass. In terms of biological activity, A-674563 is associated with three recorded protein targets. It acts as an inhibitor of the cAMP-dependent protein kinase catalytic subunit alpha (PRKACA), the cAMP-dependent protein kinase inhibitor alpha (PKIA), and the RAC-alpha serine/threonine-protein kinase (AKT1).</description> <cas>552325-73-2</cas> <pubchem-id nil="true"/> <chemical-formula>C22H22N4O</chemical-formula> <weight nil="true"/> <appearance nil="true"/> <melting-point nil="true"/> <boiling-point nil="true"/> <density nil="true"/> <solubility nil="true"/> <specific-gravity nil="true"/> <flash-point nil="true"/> <vapour-pressure nil="true"/> <route-of-exposure nil="true"/> <target nil="true"/> <mechanism-of-toxicity nil="true"/> <metabolism nil="true"/> <toxicity nil="true"/> <lethaldose nil="true"/> <carcinogenicity nil="true"/> <use-source nil="true"/> <min-risk-level nil="true"/> <health-effects nil="true"/> <symptoms nil="true"/> <treatment nil="true"/> <created-at type="dateTime">2026-04-14T17:26:38Z</created-at> <updated-at type="dateTime">2026-05-14T18:58:38Z</updated-at> <interacting-proteins nil="true"/> <wikipedia nil="true"/> <uniprot-id nil="true"/> <kegg-compound-id nil="true"/> <omim-id nil="true"/> <chebi-id nil="true"/> <biocyc-id nil="true"/> <ctd-id nil="true"/> <stitch-id nil="true"/> <drugbank-id>DB08568</drugbank-id> <pdb-id nil="true"/> <actor-id nil="true"/> <organism nil="true"/> <export type="boolean">true</export> <metabolizing-proteins nil="true"/> <transporting-proteins nil="true"/> <moldb-smiles>CC1=NNC2=C1C=C(C=C2)C1=CC(OC[C@@H](N)CC2=CC=CC=C2)=CN=C1</moldb-smiles> <moldb-formula>C22H22N4O</moldb-formula> <moldb-inchi>InChI=1S/C22H22N4O/c1-15-21-11-17(7-8-22(21)26-25-15)18-10-20(13-24-12-18)27-14-19(23)9-16-5-3-2-4-6-16/h2-8,10-13,19H,9,14,23H2,1H3,(H,25,26)/t19-/m0/s1</moldb-inchi> <moldb-inchikey>BPNUQXPIQBZCMR-IBGZPJMESA-N</moldb-inchikey> <moldb-average-mass type="decimal">358.4363</moldb-average-mass> <moldb-mono-mass type="decimal">358.179361346</moldb-mono-mass> <origin nil="true"/> <state nil="true"/> <logp>2.98</logp> <hmdb-id nil="true"/> <chembl-id nil="true"/> <chemspider-id nil="true"/> <structure-image-file-name nil="true"/> <structure-image-content-type nil="true"/> <structure-image-file-size type="integer" nil="true"/> <structure-image-updated-at type="dateTime" nil="true"/> <biodb-id nil="true"/> <synthesis-reference nil="true"/> <structure-image-caption nil="true"/> <chemdb-id>CHEM130236</chemdb-id> <dsstox-id nil="true"/> <toxcast-id nil="true"/> <stoff-ident-origin nil="true"/> <stoff-ident-id nil="true"/> <susdat-id nil="true"/> <iupac>(2S)-1-{[5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl]oxy}-3-phenylpropan-2-amine</iupac> <moldb-polar-surface-area nil="true"/> <moldb-refractivity nil="true"/> <moldb-polarizability nil="true"/> <moldb-rotatable-bond-count nil="true"/> <moldb-acceptor-count nil="true"/> <moldb-donor-count nil="true"/> <moldb-pka-strongest-acidic nil="true"/> <moldb-pka-strongest-basic nil="true"/> <moldb-physiological-charge nil="true"/> <moldb-number-of-rings nil="true"/> <moldb-alogps-logp nil="true"/> <moldb-alogps-logs nil="true"/> <moldb-alogps-solubility nil="true"/> <kingdom>Organic compounds</kingdom> <superklass>Benzenoids</superklass> <klass>Benzene and substituted derivatives</klass> <subklass>Phenethylamines</subklass> <paper-count type="integer">113</paper-count> <sync-id>CED0018348</sync-id> <structure-inchikey>BPNUQXPIQBZCMR-IBGZPJMESA-N</structure-inchikey> <structure-fingerprint>40000000000000000021800800000320000200000000000004008000000000004000000000000000200000000000002004000000000000000000000000000000000000000080000000000000000000000000000000000100002000000000000000006000000000000000004000100000800000000000000000000000000000000000000040200000800000200000000000801000000500000000800000000000000000000000000000040000080000000000000004080000400000040000000100000000000000801000200010000000000000000000002000000220000040000000000000000000000040000000000000001000000000000000080000000000</structure-fingerprint> <structure-pattern-fingerprint>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</structure-pattern-fingerprint> <structure-pickle>ï¾­Þ������������������������€���`������@(������@(������@8�������@(������@(������@h�������@(������@h�������@h�������@(������@h�������@(�������(�������`������ 4��������`�������`������@(������@h�������@h�������@h�������@h�������@h�������@h�������@(������@h������������h���h���h���h���h���h���h�� h�� �h���h�� ����������������h���h���h���h���h���h���h���h���h�� h� �h���h�B�������������� �������� �����������������</structure-pickle> <structure-indexed-at type="dateTime">2026-09-19T04:49:25Z</structure-indexed-at> </compound>