133865 <common-name>R-348</common-name> <description>R-348 is an organic compound with the formula C23H22FN5O4S and an average molecular weight of 483.52 g/mol. R-348 belongs to the benzenesulfonamides, a subclass of benzene and substituted derivatives within the organic compounds. In terms of biological activity, the compound has one recorded protein target, which is the tyrosine-protein kinase JAK3.</description> <cas>916742-11-5</cas> <pubchem-id>23648971</pubchem-id> <chemical-formula>C23H22FN5O4S</chemical-formula> <weight>483.5</weight> <appearance nil="true"/> <melting-point nil="true"/> <boiling-point nil="true"/> <density nil="true"/> <solubility nil="true"/> <specific-gravity nil="true"/> <flash-point nil="true"/> <vapour-pressure nil="true"/> <route-of-exposure nil="true"/> <target nil="true"/> <mechanism-of-toxicity nil="true"/> <metabolism nil="true"/> <toxicity nil="true"/> <lethaldose nil="true"/> <carcinogenicity nil="true"/> <use-source nil="true"/> <min-risk-level nil="true"/> <health-effects nil="true"/> <symptoms nil="true"/> <treatment nil="true"/> <created-at type="dateTime">2026-04-14T16:07:44Z</created-at> <updated-at type="dateTime">2026-08-21T23:57:12Z</updated-at> <interacting-proteins nil="true"/> <wikipedia nil="true"/> <uniprot-id nil="true"/> <kegg-compound-id nil="true"/> <omim-id nil="true"/> <chebi-id nil="true"/> <biocyc-id nil="true"/> <ctd-id nil="true"/> <stitch-id nil="true"/> <drugbank-id>DB06321</drugbank-id> <pdb-id nil="true"/> <actor-id nil="true"/> <organism nil="true"/> <export type="boolean">true</export> <metabolizing-proteins nil="true"/> <transporting-proteins nil="true"/> <moldb-smiles>CCC(=O)NS(=O)(=O)C1=CC(NC2=NC=C(F)C(NC3=CC=C(OCC#C)C=C3)=N2)=CC=C1C</moldb-smiles> <moldb-formula>C23H22FN5O4S</moldb-formula> <moldb-inchi>InChI=1S/C23H22FN5O4S/c1-4-12-33-18-10-8-16(9-11-18)26-22-19(24)14-25-23(28-22)27-17-7-6-15(3)20(13-17)34(31,32)29-21(30)5-2/h1,6-11,13-14H,5,12H2,2-3H3,(H,29,30)(H2,25,26,27,28)</moldb-inchi> <moldb-inchikey>IGLNXKVGKIFNBQ-UHFFFAOYSA-N</moldb-inchikey> <moldb-average-mass type="decimal">483.52</moldb-average-mass> <moldb-mono-mass type="decimal">483.137653545</moldb-mono-mass> <origin nil="true"/> <state nil="true"/> <logp>4.22</logp> <hmdb-id nil="true"/> <chembl-id nil="true"/> <chemspider-id nil="true"/> <structure-image-file-name nil="true"/> <structure-image-content-type nil="true"/> <structure-image-file-size type="integer" nil="true"/> <structure-image-updated-at type="dateTime" nil="true"/> <biodb-id nil="true"/> <synthesis-reference nil="true"/> <structure-image-caption nil="true"/> <chemdb-id>CHEM129758</chemdb-id> <dsstox-id nil="true"/> <toxcast-id nil="true"/> <stoff-ident-origin nil="true"/> <stoff-ident-id nil="true"/> <susdat-id nil="true"/> <iupac>N-{5-[(5-fluoro-4-{[4-(prop-2-yn-1-yloxy)phenyl]amino}pyrimidin-2-yl)amino]-2-methylbenzenesulfonyl}propanamide</iupac> <moldb-polar-surface-area nil="true"/> <moldb-refractivity nil="true"/> <moldb-polarizability nil="true"/> <moldb-rotatable-bond-count nil="true"/> <moldb-acceptor-count nil="true"/> <moldb-donor-count nil="true"/> <moldb-pka-strongest-acidic nil="true"/> <moldb-pka-strongest-basic nil="true"/> <moldb-physiological-charge nil="true"/> <moldb-number-of-rings nil="true"/> <moldb-alogps-logp nil="true"/> <moldb-alogps-logs nil="true"/> <moldb-alogps-solubility nil="true"/> <kingdom>Organic compounds</kingdom> <superklass>Benzenoids</superklass> <klass>Benzene and substituted derivatives</klass> <subklass>Benzenesulfonamides</subklass> <paper-count type="integer">400</paper-count> <sync-id>CED0012058</sync-id> <structure-inchikey>IGLNXKVGKIFNBQ-UHFFFAOYSA-N</structure-inchikey> <structure-fingerprint>4000000000800002000000000000000000000100000000000000000000000002001000204000020000002000800000000000000020000000100200000800008200000000100000000000000020000020000110880200000000000000000100010000000010002000100080200010000000000000020000000000000000040040000000000000000000040080000010000000000000000000000000000000000000000000000200080110000000000000080000080020002000080100000000000220000000010000000000000000100000002000002200000000000000000000008001000040000000000600800000000000000000000000000000</structure-fingerprint> 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