133750 <common-name>Cariprazine</common-name> <description>Cariprazine is an organic compound with the chemical formula C21H32Cl2N4O and an average molecular weight of 427.41 g/mol. Cariprazine belongs to the piperazines, a subclass of diazinanes within the organic compounds. It is classified as an organoheterocyclic compound. This compound is found in or released from one recorded source: healthcare, pharmaceuticals & veterinary products, specifically as an antipsychotic. The recorded route of exposure is oral. Cariprazine interacts with eight recorded protein targets. It acts as an antagonist or partial agonist of the D(2) dopamine receptor (DRD2), the D(3) dopamine receptor (DRD3), the 5-hydroxytryptamine receptor 1A (HTR1A), and the 5-hydroxytryptamine receptor 2B (HTR2B). Additionally, it targets four other proteins.</description> <cas>839712-12-8</cas> <pubchem-id nil="true"/> <chemical-formula>C21H32Cl2N4O</chemical-formula> <weight nil="true"/> <appearance nil="true"/> <melting-point nil="true"/> <boiling-point nil="true"/> <density nil="true"/> <solubility nil="true"/> <specific-gravity nil="true"/> <flash-point nil="true"/> <vapour-pressure nil="true"/> <route-of-exposure nil="true"/> <target nil="true"/> <mechanism-of-toxicity nil="true"/> <metabolism nil="true"/> <toxicity nil="true"/> <lethaldose nil="true"/> <carcinogenicity nil="true"/> <use-source nil="true"/> <min-risk-level nil="true"/> <health-effects nil="true"/> <symptoms nil="true"/> <treatment nil="true"/> <created-at type="dateTime">2026-04-14T15:57:53Z</created-at> <updated-at type="dateTime">2026-05-14T18:17:27Z</updated-at> <interacting-proteins nil="true"/> <wikipedia nil="true"/> <uniprot-id nil="true"/> <kegg-compound-id nil="true"/> <omim-id nil="true"/> <chebi-id nil="true"/> <biocyc-id nil="true"/> <ctd-id nil="true"/> <stitch-id nil="true"/> <drugbank-id>DB06016</drugbank-id> <pdb-id nil="true"/> <actor-id nil="true"/> <organism nil="true"/> <export type="boolean">true</export> <metabolizing-proteins nil="true"/> <transporting-proteins nil="true"/> <moldb-smiles>CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)C2=C(Cl)C(Cl)=CC=C2)CC1</moldb-smiles> <moldb-formula>C21H32Cl2N4O</moldb-formula> <moldb-inchi>InChI=1S/C21H32Cl2N4O/c1-25(2)21(28)24-17-8-6-16(7-9-17)10-11-26-12-14-27(15-13-26)19-5-3-4-18(22)20(19)23/h3-5,16-17H,6-15H2,1-2H3,(H,24,28)/t16-,17-</moldb-inchi> <moldb-inchikey>KPWSJANDNDDRMB-QAQDUYKDSA-N</moldb-inchikey> <moldb-average-mass type="decimal">427.41</moldb-average-mass> <moldb-mono-mass type="decimal">426.1953171</moldb-mono-mass> <origin nil="true"/> <state nil="true"/> <logp>4.06</logp> <hmdb-id nil="true"/> <chembl-id nil="true"/> <chemspider-id nil="true"/> <structure-image-file-name nil="true"/> <structure-image-content-type nil="true"/> <structure-image-file-size type="integer" nil="true"/> <structure-image-updated-at type="dateTime" nil="true"/> <biodb-id nil="true"/> <synthesis-reference nil="true"/> <structure-image-caption nil="true"/> <chemdb-id>CHEM129643</chemdb-id> <dsstox-id nil="true"/> <toxcast-id nil="true"/> <stoff-ident-origin nil="true"/> <stoff-ident-id nil="true"/> <susdat-id nil="true"/> <iupac>3,3-dimethyl-1-[(1r,4r)-4-{2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl}cyclohexyl]urea</iupac> <moldb-polar-surface-area nil="true"/> <moldb-refractivity nil="true"/> <moldb-polarizability nil="true"/> <moldb-rotatable-bond-count nil="true"/> <moldb-acceptor-count nil="true"/> <moldb-donor-count nil="true"/> <moldb-pka-strongest-acidic nil="true"/> <moldb-pka-strongest-basic nil="true"/> <moldb-physiological-charge nil="true"/> <moldb-number-of-rings nil="true"/> <moldb-alogps-logp nil="true"/> <moldb-alogps-logs nil="true"/> <moldb-alogps-solubility nil="true"/> <kingdom>Organic compounds</kingdom> <superklass>Organoheterocyclic compounds</superklass> <klass>Diazinanes</klass> <subklass>Piperazines</subklass> <paper-count type="integer">1991</paper-count> <sync-id>CED0006554</sync-id> <structure-inchikey>KPWSJANDNDDRMB-QAQDUYKDSA-N</structure-inchikey> <structure-fingerprint>40080400000000002080000000200000000000000000014000000001000000100000000000000000000000000200001000010000000000000000000000000000000000000040000000000000000000002000000000000000000000000000000000000001000000800400000000400000000002010000000002000000001010000100004000000080000000000000408010000000000000000000000000040200010000000400000000000008000000000000000000000000a000000800000000000000000000000000000020010500010010000000000000000208000000010000000000000000000040000040000400000000000000000000000000000000</structure-fingerprint> 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