107614 <common-name>4-(2-Amino-4-methyl-1,3-thiazol-5-yl)-n-[4-(morpholin-4-yl)phenyl]-2,5-dihydropyrimidin-2-imine</common-name> <description>4-(2-Amino-4-methyl-1,3-thiazol-5-yl)-n-[4-(morpholin-4-yl)phenyl]-2,5-dihydropyrimidin-2-imine belongs to the morpholines, a subclass of oxazinanes within the organic compounds. This organoheterocyclic compound has the chemical formula C18H20N6OS and an average molecular weight of 368.46 g/mol. In terms of biological activity, two protein targets have been recorded for this compound: Cyclin-dependent kinase 2 (CDK2) and Cyclin-A2 (CCNA2).</description> <cas>1059105-22-4</cas> <pubchem-id nil="true"/> <chemical-formula>C18H20N6OS</chemical-formula> <weight nil="true"/> <appearance nil="true"/> <melting-point nil="true"/> <boiling-point nil="true"/> <density nil="true"/> <solubility nil="true"/> <specific-gravity nil="true"/> <flash-point nil="true"/> <vapour-pressure nil="true"/> <route-of-exposure nil="true"/> <target nil="true"/> <mechanism-of-toxicity nil="true"/> <metabolism nil="true"/> <toxicity nil="true"/> <lethaldose nil="true"/> <carcinogenicity nil="true"/> <use-source nil="true"/> <min-risk-level nil="true"/> <health-effects nil="true"/> <symptoms nil="true"/> <treatment nil="true"/> <created-at type="dateTime">2026-04-05T13:59:48Z</created-at> <updated-at type="dateTime">2026-05-14T18:55:33Z</updated-at> <interacting-proteins nil="true"/> <wikipedia nil="true"/> <uniprot-id nil="true"/> <kegg-compound-id nil="true"/> <omim-id nil="true"/> <chebi-id nil="true"/> <biocyc-id nil="true"/> <ctd-id nil="true"/> <stitch-id nil="true"/> <drugbank-id>DB08219</drugbank-id> <pdb-id nil="true"/> <actor-id nil="true"/> <organism nil="true"/> <export type="boolean">true</export> <metabolizing-proteins nil="true"/> <transporting-proteins nil="true"/> <moldb-smiles>CC1=C(SC(N)=N1)C1=N\C(=N/C2=CC=C(C=C2)N2CCOCC2)N=CC1</moldb-smiles> <moldb-formula>C18H20N6OS</moldb-formula> <moldb-inchi>InChI=1S/C18H20N6OS/c1-12-16(26-17(19)21-12)15-6-7-20-18(23-15)22-13-2-4-14(5-3-13)24-8-10-25-11-9-24/h2-5,7H,6,8-11H2,1H3,(H2,19,21)/b22-18-</moldb-inchi> <moldb-inchikey>RPSZSAKYXPWBRR-PYCFMQQDSA-N</moldb-inchikey> <moldb-average-mass type="decimal">368.456</moldb-average-mass> <moldb-mono-mass type="decimal">368.1419303</moldb-mono-mass> <origin nil="true"/> <state nil="true"/> <logp>2.02</logp> <hmdb-id nil="true"/> <chembl-id nil="true"/> <chemspider-id nil="true"/> <structure-image-file-name nil="true"/> <structure-image-content-type nil="true"/> <structure-image-file-size type="integer" nil="true"/> <structure-image-updated-at type="dateTime" nil="true"/> <biodb-id nil="true"/> <synthesis-reference nil="true"/> <structure-image-caption nil="true"/> <chemdb-id>CHEM103507</chemdb-id> <dsstox-id nil="true"/> <toxcast-id nil="true"/> <stoff-ident-origin nil="true"/> <stoff-ident-id nil="true"/> <susdat-id>NS00073339</susdat-id> <iupac>4-methyl-5-[(2Z)-2-{[4-(morpholin-4-yl)phenyl]imino}-2,5-dihydropyrimidin-4-yl]-1,3-thiazol-2-amine</iupac> <moldb-polar-surface-area nil="true"/> <moldb-refractivity nil="true"/> <moldb-polarizability nil="true"/> <moldb-rotatable-bond-count nil="true"/> <moldb-acceptor-count nil="true"/> <moldb-donor-count nil="true"/> <moldb-pka-strongest-acidic nil="true"/> <moldb-pka-strongest-basic nil="true"/> <moldb-physiological-charge nil="true"/> <moldb-number-of-rings nil="true"/> <moldb-alogps-logp nil="true"/> <moldb-alogps-logs nil="true"/> <moldb-alogps-solubility nil="true"/> <kingdom>Organic compounds</kingdom> <superklass>Organoheterocyclic compounds</superklass> <klass>Oxazinanes</klass> <subklass>Morpholines</subklass> <paper-count type="integer">0</paper-count> <sync-id>CED0116004</sync-id> <structure-inchikey>RPSZSAKYXPWBRR-PYCFMQQDSA-N</structure-inchikey> <structure-fingerprint>8000000000000000020000000002000000044000000000000000000000000000000000020000001000000000000000000000000000010000100800000000000000100000000008000100100000002040000000000000000000000000000020000020000010000000381100200000000010000020000000000400000000000000000000000000010000000000000000000000080000002040000020000000000000820000400200000400040000080000000000000000000000000000000000000000000000000000000000020000002000000000000000000400000030000400000000010000000000004000000000000000c0000</structure-fingerprint> <structure-pattern-fingerprint>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</structure-pattern-fingerprint> <structure-pickle>ï¾­Þ������������������������€���`������@(������@(������@(������@(�������h�������@(�������(�������(�������(�������(������@(������@h�������@h�������@(������@h�������@h��������(�������`�������`������� ������`�������`�������(�������h��������`�����������h���h���h��� ��h��� ��(�� $� *����� �$���h�� h� �h���h���h��� ��������������� � ��(������h������h����B������������ ������ ���������������������</structure-pickle> <structure-indexed-at type="dateTime">2026-09-19T04:42:27Z</structure-indexed-at> </compound>