107103 <common-name>Telotristat Ethyl</common-name> <description>Telotristat Ethyl is an organic compound with the formula C27H26ClF3N6O3. Telotristat Ethyl belongs to the amino acids, peptides, and analogues, a subclass of carboxylic acids and derivatives within the organic compounds. With an average molecular weight of 574.99 g/mol, Telotristat Ethyl is a heavy molecule. This compound acts as an antagonist of two protein targets: Tryptophan 5-hydroxylase 1 (TPH1) and Tryptophan 5-hydroxylase 2 (TPH2).</description> <cas>1033805-22-9</cas> <pubchem-id>25181577</pubchem-id> <chemical-formula>C27H26ClF3N6O3</chemical-formula> <weight>575</weight> <appearance nil="true"/> <melting-point nil="true"/> <boiling-point nil="true"/> <density nil="true"/> <solubility nil="true"/> <specific-gravity nil="true"/> <flash-point nil="true"/> <vapour-pressure nil="true"/> <route-of-exposure nil="true"/> <target nil="true"/> <mechanism-of-toxicity nil="true"/> <metabolism nil="true"/> <toxicity nil="true"/> <lethaldose nil="true"/> <carcinogenicity nil="true"/> <use-source nil="true"/> <min-risk-level nil="true"/> <health-effects nil="true"/> <symptoms nil="true"/> <treatment nil="true"/> <created-at type="dateTime">2026-04-05T13:39:19Z</created-at> <updated-at type="dateTime">2026-08-22T07:19:27Z</updated-at> <interacting-proteins nil="true"/> <wikipedia nil="true"/> <uniprot-id nil="true"/> <kegg-compound-id nil="true"/> <omim-id nil="true"/> <chebi-id nil="true"/> <biocyc-id nil="true"/> <ctd-id nil="true"/> <stitch-id nil="true"/> <drugbank-id>DB12095</drugbank-id> <pdb-id nil="true"/> <actor-id nil="true"/> <organism nil="true"/> <export type="boolean">true</export> <metabolizing-proteins nil="true"/> <transporting-proteins nil="true"/> <moldb-smiles>CCOC(=O)[C@@H](N)CC1=CC=C(C=C1)C1=NC(N)=NC(O[C@H](C2=CC=C(Cl)C=C2N2C=CC(C)=N2)C(F)(F)F)=C1</moldb-smiles> <moldb-formula>C27H26ClF3N6O3</moldb-formula> <moldb-inchi>InChI=1S/C27H26ClF3N6O3/c1-3-39-25(38)20(32)12-16-4-6-17(7-5-16)21-14-23(35-26(33)34-21)40-24(27(29,30)31)19-9-8-18(28)13-22(19)37-11-10-15(2)36-37/h4-11,13-14,20,24H,3,12,32H2,1-2H3,(H2,33,34,35)/t20-,24+/m0/s1</moldb-inchi> <moldb-inchikey>MDSQOJYHHZBZKA-GBXCKJPGSA-N</moldb-inchikey> <moldb-average-mass type="decimal">574.99</moldb-average-mass> <moldb-mono-mass type="decimal">574.170701</moldb-mono-mass> <origin nil="true"/> <state nil="true"/> <logp>5.54</logp> <hmdb-id nil="true"/> <chembl-id nil="true"/> <chemspider-id nil="true"/> <structure-image-file-name nil="true"/> <structure-image-content-type nil="true"/> <structure-image-file-size type="integer" nil="true"/> <structure-image-updated-at type="dateTime" nil="true"/> <biodb-id nil="true"/> <synthesis-reference nil="true"/> <structure-image-caption nil="true"/> <chemdb-id>CHEM102996</chemdb-id> <dsstox-id nil="true"/> <toxcast-id nil="true"/> <stoff-ident-origin nil="true"/> <stoff-ident-id nil="true"/> <susdat-id>NS00072568</susdat-id> <iupac>ethyl (2S)-2-amino-3-(4-{2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyrimidin-4-yl}phenyl)propanoate</iupac> <moldb-polar-surface-area nil="true"/> <moldb-refractivity nil="true"/> <moldb-polarizability nil="true"/> <moldb-rotatable-bond-count nil="true"/> <moldb-acceptor-count nil="true"/> <moldb-donor-count nil="true"/> <moldb-pka-strongest-acidic nil="true"/> <moldb-pka-strongest-basic nil="true"/> <moldb-physiological-charge nil="true"/> <moldb-number-of-rings nil="true"/> <moldb-alogps-logp nil="true"/> <moldb-alogps-logs nil="true"/> <moldb-alogps-solubility nil="true"/> <kingdom>Organic compounds</kingdom> <superklass>Organic acids and derivatives</superklass> <klass>Carboxylic acids and derivatives</klass> <subklass>Amino acids, peptides, and analogues</subklass> <paper-count type="integer">286</paper-count> <sync-id>CED0013509</sync-id> <structure-inchikey>MDSQOJYHHZBZKA-GBXCKJPGSA-N</structure-inchikey> <structure-fingerprint>4000008000000000000180000000200000801000040000000000008000040000000000000a000200000000000000002000400040000000100000000000000000000000000200400000000000000000000020008000020100000000000000000000002000050080000000004000100000800009000100000000000800000000400000000040000000004400000000000000801000080000000000028000000000000100000000000000000000080004000000000000054000000000000000000000000000200000000010000000100000000110000002002010000220000000000000002000000041000040002000000420800000080010100000000000000000</structure-fingerprint> <structure-pattern-fingerprint>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</structure-pattern-fingerprint> <structure-pickle>ï¾­Þ����������������(���+���€���`�������`�������(�������(�������(������ 4��������`�������`������@(������@h�������@h�������@(������@h�������@h�������@(������@(������@(�������h�������@(������@(�������(������ 4�������@(������@h�������@h�������@(������� �����@h�������@(������@(������@h�������@h�������@(�������`������@(������� ���� � ���� � ���� � �����@h��������������� ��(�������������� h� h� �h���h�� h��� ��h���h��� ��h���h��� ��������h���h���h������h���h��� ��h���h�� h� !� "h��#�#$�#%�#&��'h� �h�'�h���h�"�h�B������ �� �����'�����������" �����������</structure-pickle> <structure-indexed-at type="dateTime">2026-09-19T04:42:15Z</structure-indexed-at> </compound>